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Items: 1 to 20 of 135

1.

A solid phase extraction-liquid chromatographic-tandem mass spectrometry method for determination of concentrations of GDC-0941, a small molecule class I phosphatidylinositide 3-kinase inhibitor, to support clinical development.

Ding X, Morrison G, Dean B, Hop CE, Tobler L, Percey S, Meng M, Reuschel S, West DA, Holden S, Ware JA.

J Pharm Biomed Anal. 2012 Mar 5;61:1-7. doi: 10.1016/j.jpba.2011.11.005. Epub 2011 Nov 25.

PMID:
22169467
2.

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry.

Ding X, Chou B, Graham RA, Cheeti S, Percey S, Matassa LC, Reuschel SA, Meng M, Liu S, Voelker T, Lum BL, Rudewicz PJ, Hop CE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 15;878(9-10):785-90. doi: 10.1016/j.jchromb.2010.01.039. Epub 2010 Feb 1.

PMID:
20172765
3.

A supported liquid extraction-LC-MS/MS method for determination of GDC-0980 (Apitolisib), a dual small-molecule inhibitor of class 1A phosphoinositide 3-kinase and mammalian target of rapamycin, in human plasma.

Ding X, Li F, McKnight J, Schmidt C, Strooisma K, Shimizu H, Faber K, Ware JA, Dean B.

J Pharm Biomed Anal. 2014 Nov;100:150-156. doi: 10.1016/j.jpba.2014.08.001. Epub 2014 Aug 10.

PMID:
25165011
4.

A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma.

Ding X, Chen Y, Sahasranaman S, Shi Y, McKnight J, Dean B.

Biomed Chromatogr. 2016 Dec;30(12):1984-1991. doi: 10.1002/bmc.3775. Epub 2016 Jul 5.

PMID:
27245274
5.

Validation and determination of taselisib, a β-sparing phosphoinositide 3-kinase (PI3K) inhibitor, in human plasma by LC-MS/MS.

Ding X, Faber K, Shi Y, McKnight J, Dorshorst D, Ware JA, Dean B.

J Pharm Biomed Anal. 2016 Jul 15;126:117-23. doi: 10.1016/j.jpba.2016.04.030. Epub 2016 Apr 20.

PMID:
27187764
6.

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction.

Shin YG, Jones SA, Murakami SC, Budha N, Ware J, Wong H, Buonarati MH, Dean B, Hop CE.

Biomed Chromatogr. 2013 Jan;27(1):102-10. doi: 10.1002/bmc.2754. Epub 2012 May 24.

PMID:
22623056
7.

Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry.

Deng Y, Wong H, Graham RA, Liu W, Shen HS, Shi Y, Wang L, Meng M, Malhi V, Ding X, Dean B.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 15;879(22):2119-26. doi: 10.1016/j.jchromb.2011.05.048. Epub 2011 Jun 12.

PMID:
21704573
8.

Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma.

Ghassabian S, Wright LA, Dejager AD, Smith MT.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jan 15;881-882:34-41. doi: 10.1016/j.jchromb.2011.11.031. Epub 2011 Nov 28.

PMID:
22197608
9.

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0879 and its metabolite in dog plasma using solid phase extraction.

Chou B, Adler RS, Meng M, Percey S, Dean B, Hop CE, Shin YG.

J Pharm Biomed Anal. 2012 Nov;70:354-61. doi: 10.1016/j.jpba.2012.05.029. Epub 2012 Jun 1.

PMID:
22717139
10.

Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry.

Xu Y, Du L, Soli ED, Braun MP, Dean DC, Musson DG.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 25;817(2):287-96.

PMID:
15686997
11.

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of G-856 (Cur-61414) in human plasma using semi-automated solid phase extraction.

Shin YG, Murakami SC, Buonarati MH, Dean B, Hop CE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 1;887-888:85-92. doi: 10.1016/j.jchromb.2012.01.016. Epub 2012 Jan 25.

PMID:
22317788
12.

Determination of GDC-0980 (apitolisib), a small molecule dual phosphatidylinositide 3-kinase/mammalian target of rapamycin inhibitor in dog plasma by LC-MS/MS to support a GLP toxicology study.

Ding X, Salphati L, Kim A, Morinello E, Wong L, Pang J, Percey S, Meng M, Reuschel S, Dean B.

Biomed Chromatogr. 2015 Aug;29(8):1274-9. doi: 10.1002/bmc.3417. Epub 2015 Feb 10.

PMID:
25677784
13.

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0834 and its metabolite in human plasma using semi-automated 96-well protein precipitation.

Shin YG, Jones SA, Murakami SC, Liu L, Wong H, Buonarati MH, Hop CE.

Biomed Chromatogr. 2012 Nov;26(11):1444-51. doi: 10.1002/bmc.2716. Epub 2012 Feb 7.

PMID:
22311651
14.

Simultaneous determination of propranolol and 4-hydroxy propranolol in human plasma by solid phase extraction and liquid chromatography/electrospray tandem mass spectrometry.

Partani P, Modhave Y, Gurule S, Khuroo A, Monif T.

J Pharm Biomed Anal. 2009 Dec 5;50(5):966-76. doi: 10.1016/j.jpba.2009.06.050. Epub 2009 Jul 7.

PMID:
19640669
15.

High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS.

Ghassabian S, Moosavi SM, Valero YG, Shekar K, Fraser JF, Smith MT.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:126-33. doi: 10.1016/j.jchromb.2012.07.005. Epub 2012 Jul 20.

PMID:
22841553
16.

Simultaneous quantitation of polymyxin B1, polymyxin B2 and polymyxin B1-1 in human plasma and treated human urine using solid phase extraction and liquid chromatography-tandem mass spectrometry.

Meng M, Wang L, Liu S, Jaber OM, Gao L, Chevrette L, Reuschel S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:23-36. doi: 10.1016/j.jchromb.2016.01.013. Epub 2016 Jan 12.

PMID:
26803416
17.

Validation of an on-line solid-phase extraction method coupled to liquid chromatography-tandem mass spectrometry detection for the determination of Indacaterol in human serum.

Emotte C, Heudi O, Deglave F, Bonvie A, Masson L, Picard F, Chaturvedi A, Majumdar T, Agarwal A, Woessner R, Kretz O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 1;895-896:1-9. doi: 10.1016/j.jchromb.2012.02.025. Epub 2012 Feb 25.

PMID:
22483398
18.

Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.

Emotte C, Deglave F, Heudi O, Picard F, Kretz O.

J Pharm Biomed Anal. 2012 Jan 25;58:102-12. doi: 10.1016/j.jpba.2011.09.021. Epub 2011 Sep 24.

PMID:
22018890
20.

Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.

Yang L, Clement RP, Kantesaria B, Reyderman L, Beaudry F, Grandmaison C, Di Donato L, Masse R, Rudewicz PJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 25;792(2):229-40.

PMID:
12860030

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