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Items: 1 to 20 of 127

1.

Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.

Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR.

Mol Cell Biol. 2012 Feb;32(4):740-50. doi: 10.1128/MCB.06470-11. Epub 2011 Dec 12.

2.

Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity.

Pulinilkunnil T, Kienesberger PC, Nagendran J, Sharma N, Young ME, Dyck JR.

Int J Obes (Lond). 2014 Feb;38(2):205-15. doi: 10.1038/ijo.2013.103. Epub 2013 Jun 5.

PMID:
23817015
3.

Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy.

Pulinilkunnil T, Kienesberger PC, Nagendran J, Waller TJ, Young ME, Kershaw EE, Korbutt G, Haemmerle G, Zechner R, Dyck JR.

Diabetes. 2013 May;62(5):1464-77. doi: 10.2337/db12-0927. Epub 2013 Jan 24.

4.

Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation.

Kienesberger PC, Pulinilkunnil T, Nagendran J, Young ME, Bogner-Strauss JG, Hackl H, Khadour R, Heydari E, Haemmerle G, Zechner R, Kershaw EE, Dyck JR.

Cardiovasc Res. 2013 Aug 1;99(3):442-51. doi: 10.1093/cvr/cvt124. Epub 2013 May 25.

5.

Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice.

Nagendran J, Kienesberger PC, Pulinilkunnil T, Zordoky BN, Sung MM, Kim T, Young ME, Dyck JR.

Heart. 2013 Jul;99(14):1041-7. doi: 10.1136/heartjnl-2013-303843. Epub 2013 May 23.

PMID:
23704323
6.

Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides.

Gao H, Feng XJ, Li ZM, Li M, Gao S, He YH, Wang JJ, Zeng SY, Liu XP, Huang XY, Chen SR, Liu PQ.

Arch Biochem Biophys. 2015 Jan 1;565:76-88. doi: 10.1016/j.abb.2014.11.009. Epub 2014 Nov 28.

PMID:
25436917
7.

Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload.

Doenst T, Pytel G, Schrepper A, Amorim P, Färber G, Shingu Y, Mohr FW, Schwarzer M.

Cardiovasc Res. 2010 Jun 1;86(3):461-70. doi: 10.1093/cvr/cvp414. Epub 2009 Dec 24.

PMID:
20035032
8.

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning.

Ong KT, Mashek MT, Bu SY, Greenberg AS, Mashek DG.

Hepatology. 2011 Jan;53(1):116-26. doi: 10.1002/hep.24006. Epub 2010 Oct 21.

9.

Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase.

Borg ML, Andrews ZB, Duh EJ, Zechner R, Meikle PJ, Watt MJ.

Diabetes. 2011 May;60(5):1458-66. doi: 10.2337/db10-0845. Epub 2011 Apr 4.

10.

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.

Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R.

Science. 2006 May 5;312(5774):734-7.

11.

Differential effects of high-fat diet on myocardial lipid metabolism in failing and nonfailing hearts with angiotensin II-mediated cardiac remodeling in mice.

Pellieux C, Montessuit C, Papageorgiou I, Pedrazzini T, Lerch R.

Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1795-805. doi: 10.1152/ajpheart.01023.2011. Epub 2012 Mar 9.

12.

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.

Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. doi: 10.1152/ajpheart.00452.2009. Epub 2009 Oct 2.

13.

Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R.

Circulation. 2009 Jun 2;119(21):2818-28. doi: 10.1161/CIRCULATIONAHA.108.832915. Epub 2009 May 18.

14.

Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism.

Ong KT, Mashek MT, Davidson NO, Mashek DG.

J Lipid Res. 2014 May;55(5):808-15. doi: 10.1194/jlr.M039867. Epub 2014 Mar 8.

15.

Cardiac oxidative stress in a mouse model of neutral lipid storage disease.

Schrammel A, Mussbacher M, Winkler S, Haemmerle G, Stessel H, Wölkart G, Zechner R, Mayer B.

Biochim Biophys Acta. 2013 Nov;1831(11):1600-8. doi: 10.1016/j.bbalip.2013.07.004. Epub 2013 Jul 15.

16.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

17.

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R.

Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439.

18.

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

Heier C, Radner FP, Moustafa T, Schreiber R, Grond S, Eichmann TO, Schweiger M, Schmidt A, Cerk IK, Oberer M, Theussl HC, Wojciechowski J, Penninger JM, Zimmermann R, Zechner R.

J Biol Chem. 2015 Oct 23;290(43):26141-50. doi: 10.1074/jbc.M115.671842. Epub 2015 Sep 8.

19.

Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure.

Kaimoto S, Hoshino A, Ariyoshi M, Okawa Y, Tateishi S, Ono K, Uchihashi M, Fukai K, Iwai-Kanai E, Matoba S.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H305-H313. doi: 10.1152/ajpheart.00553.2016. Epub 2016 Dec 23.

PMID:
28011586
20.

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis.

Brahma MK, Adam RC, Pollak NM, Jaeger D, Zierler KA, Pöcher N, Schreiber R, Romauch M, Moustafa T, Eder S, Ruelicke T, Preiss-Landl K, Lass A, Zechner R, Haemmerle G.

J Lipid Res. 2014 Nov;55(11):2229-41. doi: 10.1194/jlr.M044784. Epub 2014 Aug 31.

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