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Items: 1 to 20 of 287

1.

Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.

Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH.

Circ Res. 2012 Feb 3;110(3):465-70. doi: 10.1161/CIRCRESAHA.111.253229. Epub 2011 Dec 8.

2.

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.

Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D.

Circulation. 2012 May 1;125(17):2059-70. doi: 10.1161/CIRCULATIONAHA.111.067306. Epub 2012 Mar 28.

3.

Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.

Shan J, Xie W, Betzenhauser M, Reiken S, Chen BX, Wronska A, Marks AR.

Circ Res. 2012 Aug 31;111(6):708-17. doi: 10.1161/CIRCRESAHA.112.273342. Epub 2012 Jul 24.

4.

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM.

Circ Res. 2005 Dec 9;97(12):1314-22. Epub 2005 Nov 3.

5.

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.

Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R, Schöndube FA, Hasenfuss G, Maier LS.

Circ Res. 2010 Apr 2;106(6):1134-44. doi: 10.1161/CIRCRESAHA.109.203836. Epub 2010 Jan 7.

6.

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH.

Heart Rhythm. 2008 Jul;5(7):1047-54. doi: 10.1016/j.hrthm.2008.03.030. Epub 2008 Mar 27.

7.

Oxidation- and CaMKII-mediated sarcoplasmic reticulum Ca(2+) leak triggers atrial fibrillation in aging.

Guo X, Yuan S, Liu Z, Fang Q.

J Cardiovasc Electrophysiol. 2014 Jun;25(6):645-52. doi: 10.1111/jce.12395. Epub 2014 May 2.

PMID:
24576293
8.

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.

Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A.

J Mol Cell Cardiol. 2014 Sep;74:274-83. doi: 10.1016/j.yjmcc.2014.06.004. Epub 2014 Jun 17.

9.

Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.

Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XH.

Circulation. 2014 Mar 25;129(12):1276-85. doi: 10.1161/CIRCULATIONAHA.113.006611. Epub 2014 Jan 7.

10.

Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.

Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XH.

Heart Rhythm. 2013 Apr;10(4):592-9. doi: 10.1016/j.hrthm.2012.12.016. Epub 2012 Dec 12.

11.

Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.

Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XH.

Cardiovasc Res. 2014 Jul 1;103(1):178-87. doi: 10.1093/cvr/cvu123. Epub 2014 May 8.

12.

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH.

J Clin Invest. 2009 Jul;119(7):1940-51.

13.

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.

Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XH, Bers DM.

J Mol Cell Cardiol. 2016 Sep;98:62-72. doi: 10.1016/j.yjmcc.2016.06.007. Epub 2016 Jun 16.

PMID:
27318036
14.

Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.

Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XH.

J Am Coll Cardiol. 2013 Nov 19;62(21):2010-9. doi: 10.1016/j.jacc.2013.06.052. Epub 2013 Aug 21.

15.

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.

Guo T, Cornea RL, Huke S, Camors E, Yang Y, Picht E, Fruen BR, Bers DM.

Circ Res. 2010 Jun 11;106(11):1743-52. doi: 10.1161/CIRCRESAHA.110.219816. Epub 2010 Apr 29.

16.

Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure.

Seidler T, Teucher N, Hellenkamp K, Unsöld B, Grebe C, Kramps P, Schotola H, Wagner S, Schöndube FA, Hasenfuss G, Maier LS.

J Mol Cell Cardiol. 2011 Jan;50(1):33-42. doi: 10.1016/j.yjmcc.2010.08.016. Epub 2010 Aug 24.

PMID:
20797399
17.

Role of RyR2 phosphorylation at S2814 during heart failure progression.

Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH.

Circ Res. 2012 May 25;110(11):1474-83. doi: 10.1161/CIRCRESAHA.112.268094. Epub 2012 Apr 17.

18.

Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.

Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1214-22. doi: 10.1161/CIRCEP.114.001973. Epub 2014 Nov 11.

19.

Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR.

Circulation. 2005 Apr 26;111(16):2025-32.

20.

Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation.

Curran J, Tang L, Roof SR, Velmurugan S, Millard A, Shonts S, Wang H, Santiago D, Ahmad U, Perryman M, Bers DM, Mohler PJ, Ziolo MT, Shannon TR.

PLoS One. 2014 Feb 3;9(2):e87495. doi: 10.1371/journal.pone.0087495. eCollection 2014.

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