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Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice.

Abdollahi-Roodsaz S, van de Loo FA, Koenders MI, Helsen MM, Walgreen B, van den Bersselaar LA, Arntz OJ, Takahashi N, Joosten LA, van den Berg WB.

Arthritis Rheum. 2012 Jun;64(6):1838-47. doi: 10.1002/art.34328. Epub 2011 Dec 6.


Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.

Joosten LA, Koenders MI, Smeets RL, Heuvelmans-Jacobs M, Helsen MM, Takeda K, Akira S, Lubberts E, van de Loo FA, van den Berg WB.

J Immunol. 2003 Dec 1;171(11):6145-53.


Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.

Abdollahi-Roodsaz S, Joosten LA, Helsen MM, Walgreen B, van Lent PL, van den Bersselaar LA, Koenders MI, van den Berg WB.

Arthritis Rheum. 2008 Dec;58(12):3753-64. doi: 10.1002/art.24127.


Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.

Koenders MI, Kolls JK, Oppers-Walgreen B, van den Bersselaar L, Joosten LA, Schurr JR, Schwarzenberger P, van den Berg WB, Lubberts E.

Arthritis Rheum. 2005 Oct;52(10):3239-47.


T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17.

Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, Helsen MM, van den Bersselaar LA, Oppers-Walgreen B, Koenders MI, van den Berg WB.

Arthritis Rheum. 2008 Jan;58(1):98-108. doi: 10.1002/art.23152.


PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells.

Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E, Willems F.

Eur J Immunol. 2010 Feb;40(2):505-15. doi: 10.1002/eji.200939391.


Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.

Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F867-74. doi: 10.1152/ajprenal.90213.2008. Epub 2009 Jan 21.


Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.

Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, Gröne HJ.

Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.


Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages.

Ruckdeschel K, Pfaffinger G, Haase R, Sing A, Weighardt H, Häcker G, Holzmann B, Heesemann J.

J Immunol. 2004 Sep 1;173(5):3320-8.


Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response.

Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B.

J Leukoc Biol. 2011 Sep;90(3):613-20. doi: 10.1189/jlb.1110602. Epub 2011 May 31.


Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus.

Buchholz BM, Billiar TR, Bauer AJ.

Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G531-8. doi: 10.1152/ajpgi.00060.2010. Epub 2010 May 27.


Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.

Yadav M, Zhang J, Fischer H, Huang W, Lutay N, Cirl C, Lum J, Miethke T, Svanborg C.

PLoS Pathog. 2010 Sep 23;6(9):e1001120. doi: 10.1371/journal.ppat.1001120.


Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis.

Grevers LC, van Lent PL, Koenders MI, Walgreen B, Sloetjes AW, Nimmerjahn F, Sjef Verbeek J, van den Berg WB.

Arthritis Rheum. 2009 Feb;60(2):396-407. doi: 10.1002/art.24288.


Pathological role of Toll-like receptor signaling in cerebral malaria.

Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.

Int Immunol. 2007 Jan;19(1):67-79. Epub 2006 Nov 29.


Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.

Science. 2003 Aug 1;301(5633):640-3. Epub 2003 Jul 10.


Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis.

Marijnissen RJ, Roeleveld DM, Young D, Nickerson-Nutter C, Abdollahi-Roodsaz S, Garcia de Aquino S, van de Loo FA, van Spriel AB, Boots AM, van den Berg WB, Koenders MI.

Arthritis Rheumatol. 2014 Apr;66(4):886-95. doi: 10.1002/art.38312.


Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis.

Shaik-Dasthagirisaheb YB, Huang N, Weinberg EO, Shen SS, Genco CA, Gibson FC 3rd.

J Periodontal Res. 2015 Feb;50(1):89-102. doi: 10.1111/jre.12185. Epub 2014 May 24.


Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.

Lubberts E, Joosten LA, van Den Bersselaar L, Helsen MM, Bakker AC, van Meurs JB, Graham FL, Richards CD, van Den Berg WB.

J Immunol. 1999 Oct 15;163(8):4546-56.


Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model.

Plater-Zyberk C, Joosten LA, Helsen MM, Koenders MI, Baeuerle PA, van den Berg WB.

Ann Rheum Dis. 2009 May;68(5):721-8. doi: 10.1136/ard.2007.085431. Epub 2008 May 21.


Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.

Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B.

Nature. 2003 Aug 14;424(6950):743-8. Epub 2003 Jul 20.


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