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Items: 1 to 20 of 134

1.

Molecular determinants of magnolol targeting both RXRα and PPARγ.

Zhang H, Xu X, Chen L, Chen J, Hu L, Jiang H, Shen X.

PLoS One. 2011;6(11):e28253. doi: 10.1371/journal.pone.0028253. Epub 2011 Nov 29.

2.

Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.

Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK.

ChemMedChem. 2009 Jul;4(7):1106-19. doi: 10.1002/cmdc.200800447.

3.

Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells.

Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT.

Life Sci. 2009 Jun 19;84(25-26):908-14. doi: 10.1016/j.lfs.2009.04.001. Epub 2009 Apr 17.

PMID:
19376135
4.

Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode.

Zhang H, Li L, Chen L, Hu L, Jiang H, Shen X.

J Mol Biol. 2011 Mar 18;407(1):13-20. doi: 10.1016/j.jmb.2011.01.032. Epub 2011 Jan 22.

PMID:
21262235
5.

Honokiol: a non-adipogenic PPARγ agonist from nature.

Atanasov AG, Wang JN, Gu SP, Bu J, Kramer MP, Baumgartner L, Fakhrudin N, Ladurner A, Malainer C, Vuorinen A, Noha SM, Schwaiger S, Rollinger JM, Schuster D, Stuppner H, Dirsch VM, Heiss EH.

Biochim Biophys Acta. 2013 Oct;1830(10):4813-9. doi: 10.1016/j.bbagen.2013.06.021. Epub 2013 Jun 27.

6.

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.

Lemkul JA, Lewis SN, Bassaganya-Riera J, Bevan DR.

PLoS One. 2015 May 8;10(5):e0123984. doi: 10.1371/journal.pone.0123984. eCollection 2015.

7.

The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain.

Lu J, Dawson MI, Hu QY, Xia Z, Dambacher JD, Ye M, Zhang XK, Li E.

Magn Reson Chem. 2009 Dec;47(12):1071-80. doi: 10.1002/mrc.2515.

8.

9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.

Singh RR, Gururaj AE, Vadlamudi RK, Kumar R.

J Biol Chem. 2006 Jun 2;281(22):15394-404. Epub 2006 Mar 30.

9.
10.

Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis.

Nakashima K, Murakami T, Tanabe H, Inoue M.

Biochim Biophys Acta. 2014 Oct;1840(10):3034-41. doi: 10.1016/j.bbagen.2014.06.011. Epub 2014 Jun 24.

PMID:
24972164
11.

Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation.

Hiromori Y, Aoki A, Nishikawa J, Nagase H, Nakanishi T.

Metallomics. 2015 Jul;7(7):1180-8. doi: 10.1039/c5mt00086f.

PMID:
25985376
12.

An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements.

Temple KA, Cohen RN, Wondisford SR, Yu C, Deplewski D, Wondisford FE.

J Biol Chem. 2005 Feb 4;280(5):3529-40. Epub 2004 Nov 29.

13.

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.

Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G.

J Med Chem. 2008 Dec 25;51(24):7768-76. doi: 10.1021/jm800733h.

PMID:
19053776
15.

Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution.

Lu J, Chen M, Stanley SE, Li E.

Biochem Biophys Res Commun. 2008 Jan 4;365(1):42-6. Epub 2007 Oct 31.

16.

Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?

Moras D.

Cell Metab. 2009 Jan 7;9(1):8-10. doi: 10.1016/j.cmet.2008.12.010.

17.

Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands.

Waku T, Shiraki T, Oyama T, Morikawa K.

FEBS Lett. 2009 Jan 22;583(2):320-4. doi: 10.1016/j.febslet.2008.12.017. Epub 2008 Dec 26.

18.

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, Nakamura M, Miao S, Cao P, Learned RM, Chen JL, Li Y.

J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4.

19.

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE.

Mol Cell. 2000 Mar;5(3):545-55.

20.

Rhodanine derivatives as novel peroxisome proliferator-activated receptor gamma agonists.

Liu Q, Zhang YY, Lu HL, Li QY, Zhou CH, Wang MW.

Acta Pharmacol Sin. 2007 Dec;28(12):2033-9.

PMID:
18031620

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