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Items: 1 to 20 of 115


Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.

Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM.

Nat Immunol. 2011 Dec 4;13(1):58-66. doi: 10.1038/ni.2182.


IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.

Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE, Nakanishi K.

Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13962-6.


Basophils are the major producers of IL-4 during primary helminth infection.

van Panhuys N, Prout M, Forbes E, Min B, Paul WE, Le Gros G.

J Immunol. 2011 Mar 1;186(5):2719-28. doi: 10.4049/jimmunol.1000940. Epub 2011 Jan 26.


Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.

Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM.

J Exp Med. 2006 Jun 12;203(6):1435-46. Epub 2006 May 15. Erratum in: J Exp Med. 2006 Jun 12;203(6):1617.


Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2.

Wang ZY, Kusam S, Munugalavadla V, Kapur R, Brutkiewicz RR, Dent AL.

J Immunol. 2006 Jan 15;176(2):880-8.


Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production.

Voehringer D, Shinkai K, Locksley RM.

Immunity. 2004 Mar;20(3):267-77.


Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.

Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A.

Immunity. 1999 Oct;11(4):473-82.


Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM.

Immunity. 2012 Feb 24;36(2):175-87. doi: 10.1016/j.immuni.2011.12.014. Epub 2012 Feb 9.


Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.

Lee DU, Rao A.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16010-5. Epub 2004 Oct 26.


Basophils: emerging roles in the pathogenesis of allergic disease.

Schroeder JT.

Immunol Rev. 2011 Jul;242(1):144-60. doi: 10.1111/j.1600-065X.2011.01023.x. Review.


Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells.

Pyo MY, Yoon SJ, Yu Y, Park S, Jin M.

Biosci Biotechnol Biochem. 2014;78(6):1037-43. doi: 10.1080/09168451.2014.912115. Epub 2014 May 28.


Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion.

Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN.

J Exp Med. 2006 Apr 17;203(4):1105-16. Epub 2006 Apr 10.


Genetic analysis of basophil function in vivo.

Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM.

Nat Immunol. 2011 Jun;12(6):527-35. doi: 10.1038/ni.2036. Epub 2011 May 8. Erratum in: Nat Immunol. 2011 Jun;12(6):3 p following 535.


Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.

Spooner CJ, Lesch J, Yan D, Khan AA, Abbas A, Ramirez-Carrozzi V, Zhou M, Soriano R, Eastham-Anderson J, Diehl L, Lee WP, Modrusan Z, Pappu R, Xu M, DeVoss J, Singh H.

Nat Immunol. 2013 Dec;14(12):1229-36. doi: 10.1038/ni.2743. Epub 2013 Oct 20.


Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion.

Schwartz C, Turqueti-Neves A, Hartmann S, Yu P, Nimmerjahn F, Voehringer D.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5169-77. doi: 10.1073/pnas.1412663111. Epub 2014 Nov 17.


Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.

Nakahira M, Nakanishi K.

Int Immunol. 2011 Dec;23(12):761-72. doi: 10.1093/intimm/dxr087. Epub 2011 Oct 29.


The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation.

Piehler D, Eschke M, Schulze B, Protschka M, Müller U, Grahnert A, Richter T, Heyen L, Köhler G, Brombacher F, Alber G.

Mucosal Immunol. 2016 Jul;9(4):937-49. doi: 10.1038/mi.2015.106. Epub 2015 Nov 11.


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