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Items: 1 to 20 of 102

1.

Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.

Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ.

Am J Pathol. 2012 Feb;180(2):636-49. doi: 10.1016/j.ajpath.2011.10.026. Epub 2011 Dec 2.

2.

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR.

Gastroenterology. 2008 Aug;135(2):552-67. doi: 10.1053/j.gastro.2008.04.037. Epub 2008 May 7.

3.

Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.

Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR.

PLoS One. 2011 Jan 11;6(1):e16090. doi: 10.1371/journal.pone.0016090.

4.

TL1A as a Potential Local Inducer of IL17A Expression in Colon Mucosa of Inflammatory Bowel Disease Patients.

Ślebioda TJ, Bojarska-Junak A, Stanisławowski M, Cyman M, Wierzbicki PM, Roliński J, Celiński K, Kmieć Z.

Scand J Immunol. 2015 Oct;82(4):352-60. doi: 10.1111/sji.12324.

5.

Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation.

Siakavellas SI, Bamias G.

Inflamm Bowel Dis. 2015 Oct;21(10):2441-52. doi: 10.1097/MIB.0000000000000492. Review.

PMID:
26099067
6.

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.

Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR.

Mucosal Immunol. 2014 Nov;7(6):1492-503. doi: 10.1038/mi.2014.37. Epub 2014 May 21.

7.

Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.

Bamias G, Mishina M, Nyce M, Ross WG, Kollias G, Rivera-Nieves J, Pizarro TT, Cominelli F.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8441-6. Epub 2006 May 12.

8.

The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice.

Krause P, Zahner SP, Kim G, Shaikh RB, Steinberg MW, Kronenberg M.

Gastroenterology. 2014 Jun;146(7):1752-62.e4. doi: 10.1053/j.gastro.2014.02.010. Epub 2014 Feb 19.

9.

Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation.

Prehn JL, Mehdizadeh S, Landers CJ, Luo X, Cha SC, Wei P, Targan SR.

Clin Immunol. 2004 Jul;112(1):66-77.

PMID:
15207783
10.

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.

Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.

Inflamm Bowel Dis. 2010 Apr;16(4):568-75. doi: 10.1002/ibd.21124.

PMID:
19834969
11.

The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation.

Bamias G, Jia LG, Cominelli F.

Curr Opin Gastroenterol. 2013 Nov;29(6):597-602. doi: 10.1097/MOG.0b013e328365d3a2. Review.

PMID:
24100723
12.

Constitutive expression of MMP9 in intestinal epithelium worsens murine acute colitis and is associated with increased levels of proinflammatory cytokine Kc.

Liu H, Patel NR, Walter L, Ingersoll S, Sitaraman SV, Garg P.

Am J Physiol Gastrointest Liver Physiol. 2013 May 1;304(9):G793-803. doi: 10.1152/ajpgi.00249.2012. Epub 2013 Mar 7.

13.

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation.

Meylan F, Song YJ, Fuss I, Villarreal S, Kahle E, Malm IJ, Acharya K, Ramos HL, Lo L, Mentink-Kane MM, Wynn TA, Migone TS, Strober W, Siegel RM.

Mucosal Immunol. 2011 Mar;4(2):172-85. doi: 10.1038/mi.2010.67. Epub 2010 Oct 27.

14.

SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS.

Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ.

Eur J Microbiol Immunol (Bp). 2013 Mar;3(1):11-20.

15.

Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.

Sidhu-Varma M, Shih DQ, Targan SR.

Inflamm Bowel Dis. 2016 Mar;22(3):548-59. doi: 10.1097/MIB.0000000000000653.

16.

Crohn's disease-associated mucosal factors regulate the expression of TNF-like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells.

Bamias G, Filidou E, Goukos D, Valatas V, Arvanitidis K, Panagopoulou M, Kouklakis G, Daikos GL, Ladas SD, Kolios G.

Transl Res. 2017 Feb;180:118-130.e2. doi: 10.1016/j.trsl.2016.08.007. Epub 2016 Sep 7.

PMID:
27665176
17.

Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia.

Taraban VY, Slebioda TJ, Willoughby JE, Buchan SL, James S, Sheth B, Smyth NR, Thomas GJ, Wang EC, Al-Shamkhani A.

Mucosal Immunol. 2011 Mar;4(2):186-96. doi: 10.1038/mi.2010.70. Epub 2010 Oct 20.

18.

Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa.

Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, Yamazaki M, Iwao Y, Ishii H, Habu S, Uehira M, Nishimoto H, Ishikawa H, Hata J, Hibi T.

J Exp Med. 1998 Feb 2;187(3):389-402.

19.

Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes.

Papadakis KA, Zhu D, Prehn JL, Landers C, Avanesyan A, Lafkas G, Targan SR.

J Immunol. 2005 Apr 15;174(8):4985-90.

20.

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF.

Gastroenterology. 2009 Jan;136(1):257-67. doi: 10.1053/j.gastro.2008.10.018. Epub 2008 Oct 9.

PMID:
18992745

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