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HMGA2 and MDM2 expression in lipomatous tumors with partial, low-level amplification of sequences from the long arm of chromosome 12.

Mandahl N, Bartuma H, Magnusson L, Isaksson M, Macchia G, Mertens F.

Cancer Genet. 2011 Oct;204(10):550-6. doi: 10.1016/j.cancergen.2011.09.005.


Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours.

Dei Tos AP, Doglioni C, Piccinin S, Sciot R, Furlanetto A, Boiocchi M, Dal Cin P, Maestro R, Fletcher CD, Tallini G.

J Pathol. 2000 Apr;190(5):531-6.


Real-time polymerase chain reaction analysis of MDM2 and CDK4 expression using total RNA from core-needle biopsies is useful for diagnosing adipocytic tumors.

Sasaki T, Ogose A, Kawashima H, Hotta T, Hatano H, Ariizumi T, Umezu H, Ohashi R, Tohyama T, Tanabe N, Endo N.

BMC Cancer. 2014 Jun 26;14:468. doi: 10.1186/1471-2407-14-468.


Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?

Italiano A, Cardot N, Dupré F, Monticelli I, Keslair F, Piche M, Mainguené C, Coindre JM, Pedeutour F.

Int J Cancer. 2007 Jul 15;121(2):308-15.


Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.

Nilsson M, Domanski H, Mertens F, Mandahl N.

Oncol Rep. 2005 Apr;13(4):649-52.


Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia.

Storlazzi CT, Mertens F, Domanski H, Fletcher CD, Wiegant J, Mandahl N.

Int J Oncol. 2003 Jul;23(1):67-71.


Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations.

Tallini G, Dal Cin P, Rhoden KJ, Chiapetta G, Manfioletti G, Giancotti V, Fusco A, Van den Berghe H, Sciot R.

Am J Pathol. 1997 Jul;151(1):37-43.


Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma.

Erickson-Johnson MR, Seys AR, Roth CW, King AA, Hulshizer RL, Wang X, Asmann YW, Lloyd RV, Jacob EK, Oliveira AM.

Mod Pathol. 2009 Dec;22(12):1541-7. doi: 10.1038/modpathol.2009.149. Epub 2009 Oct 9.


Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms.

Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, Rubin BP, Skacel M.

Mod Pathol. 2008 Aug;21(8):943-9. doi: 10.1038/modpathol.2008.84. Epub 2008 May 23.


HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre JM, Dumollard JM, Hofman P, Leroux A, Mainguené C, Peyrottes I, Ranchere-Vince D, Terrier P, Tran A, Gual P, Pedeutour F.

Int J Cancer. 2008 May 15;122(10):2233-41. doi: 10.1002/ijc.23380.


Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: a report of the CHAMP collaborative study group. CHromosomes And MorPhology.

Mandahl N, Akerman M, Aman P, Dal Cin P, De Wever I, Fletcher CD, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, Van den Berghe H, Van de Ven W, Vanni R, Willén H.

Int J Cancer. 1996 Sep 4;67(5):632-5.


Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (a report of the CHAMP Study Group).

Rosai J, Akerman M, Dal Cin P, DeWever I, Fletcher CD, Mandahl N, Mertens F, Mitelman F, Rydholm A, Sciot R, Tallini G, Van den Berghe H, Van de Ven W, Vanni R, Willen H.

Am J Surg Pathol. 1996 Oct;20(10):1182-9. Review.


Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors.

Pedeutour F, Forus A, Coindre JM, Berner JM, Nicolo G, Michiels JF, Terrier P, Ranchere-Vince D, Collin F, Myklebost O, Turc-Carel C.

Genes Chromosomes Cancer. 1999 Jan;24(1):30-41.


Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor.

Kashima T, Halai D, Ye H, Hing SN, Delaney D, Pollock R, O'Donnell P, Tirabosco R, Flanagan AM.

Mod Pathol. 2012 Oct;25(10):1384-96. doi: 10.1038/modpathol.2012.90. Epub 2012 Jun 15.


Fusion of the HMGA2 and NFIB genes in lipoma.

Nilsson M, Panagopoulos I, Mertens F, Mandahl N.

Virchows Arch. 2005 Nov;447(5):855-8. Epub 2005 Aug 17.


MDM2 Amplification in Problematic Lipomatous Tumors: Analysis of FISH Testing Criteria.

Clay MR, Martinez AP, Weiss SW, Edgar MA.

Am J Surg Pathol. 2015 Oct;39(10):1433-9. doi: 10.1097/PAS.0000000000000468.


Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups.

Bartuma H, Panagopoulos I, Collin A, Trombetta D, Domanski HA, Mandahl N, Mertens F.

Mol Cancer. 2009 Jun 9;8:36. doi: 10.1186/1476-4598-8-36.


Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2.

Pentimalli F, Dentice M, Fedele M, Pierantoni GM, Cito L, Pallante P, Santoro M, Viglietto G, Dal Cin P, Fusco A.

Cancer Res. 2003 Nov 1;63(21):7423-7.


Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype.

Bartuma H, Hallor KH, Panagopoulos I, Collin A, Rydholm A, Gustafson P, Bauer HC, Brosjö O, Domanski HA, Mandahl N, Mertens F.

Genes Chromosomes Cancer. 2007 Jun;46(6):594-606.


Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR.

Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P, Pedeutour F.

Am J Surg Pathol. 2007 Oct;31(10):1476-89.


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