Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 118

1.

The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.

Eichner S, Knobloch T, Floss HG, Fohrer J, Harmrolfs K, Hermane J, Schulz A, Sasse F, Spiteller P, Taft F, Kirschning A.

Angew Chem Int Ed Engl. 2012 Jan 16;51(3):752-7. doi: 10.1002/anie.201106249. Epub 2011 Dec 1. No abstract available.

PMID:
22135226
2.

Bioreduction of aryl azides during mutasynthesis of new ansamitocins.

Mancuso L, Jürjens G, Hermane J, Harmrolfs K, Eichner S, Fohrer J, Collisi W, Sasse F, Kirschning A.

Org Lett. 2013 Sep 6;15(17):4442-5. doi: 10.1021/ol401989e. Epub 2013 Aug 27.

PMID:
23981134
3.

New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis.

Eichner S, Floss HG, Sasse F, Kirschning A.

Chembiochem. 2009 Jul 20;10(11):1801-5. doi: 10.1002/cbic.200900246. No abstract available.

PMID:
19554593
4.

Chemoenzymatic approaches toward dechloroansamitocin P-3.

Meyer A, Brünjes M, Taft F, Frenzel T, Sasse F, Kirschning A.

Org Lett. 2007 Apr 12;9(8):1489-92. Epub 2007 Mar 23.

PMID:
17378571
5.

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.

Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.

Org Biomol Chem. 2008 Jan 21;6(2):340-8. doi: 10.1039/b713407j. Epub 2007 Nov 30.

PMID:
18175003
6.

Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.

Harmrolfs K, Brünjes M, Dräger G, Floss HG, Sasse F, Taft F, Kirschning A.

Chembiochem. 2010 Dec 10;11(18):2517-20. doi: 10.1002/cbic.201000422. No abstract available.

7.

Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis.

Ni S, Jiang B, Wu L, Wang Y, Zhou H, He W, Wang H, Zhu J, Li S, Li T, Zhang K.

J Antibiot (Tokyo). 2014 Feb;67(2):183-5. doi: 10.1038/ja.2013.94. Epub 2013 Oct 9. No abstract available.

PMID:
24105607
8.

Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.

Taft F, Brünjes M, Floss HG, Czempinski N, Grond S, Sasse F, Kirschning A.

Chembiochem. 2008 May 5;9(7):1057-60. doi: 10.1002/cbic.200700742. No abstract available.

PMID:
18381586
9.

A new antitumour ansamitocin from Actinosynnema pretiosum.

Wei GZ, Bai LQ, Yang T, Ma J, Zeng Y, Shen YM, Zhao PJ.

Nat Prod Res. 2010 Jul;24(12):1146-50. doi: 10.1080/14786410902916552.

PMID:
20582809
10.

Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.

Taft F, Harmrolfs K, Nickeleit I, Heutling A, Kiene M, Malek N, Sasse F, Kirschning A.

Chemistry. 2012 Jan 16;18(3):880-6. doi: 10.1002/chem.201101640. Epub 2011 Dec 14.

PMID:
22170289
11.

New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus.

Wu CZ, Moon AN, Jang JH, Lee D, Kang SY, Park JT, Ahn JS, Hwang BY, Kim YH, Lee HS, Hong YS.

J Antibiot (Tokyo). 2011 Jun;64(6):461-3. doi: 10.1038/ja.2011.24. Epub 2011 Mar 30. No abstract available.

PMID:
21448187
12.

New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.

Hermane J, Bułyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A.

Chembiochem. 2015 Jan 19;16(2):302-11. doi: 10.1002/cbic.201402375. Epub 2015 Jan 8.

PMID:
25572106
13.

The missing C-17 O-methyltransferase in geldanamycin biosynthesis.

Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B.

Org Lett. 2011 Jul 15;13(14):3726-9. doi: 10.1021/ol201383w. Epub 2011 Jun 17.

PMID:
21682254
14.

7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997.

Ni S, Wu L, Wang H, Wang Y, He W, Li Y, Jia C, Li S, Wang Y.

J Antibiot (Tokyo). 2010 Oct;63(10):623-5. doi: 10.1038/ja.2010.96. Epub 2010 Aug 4. No abstract available.

PMID:
20683449
15.

Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.

Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y.

Eur J Med Chem. 2014 Nov 24;87:346-63. doi: 10.1016/j.ejmech.2014.09.078. Epub 2014 Sep 28.

PMID:
25277067
16.

Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2.

Schulz D, Nachtigall J, Riedlinger J, Schneider K, Poralla K, Imhoff JF, Beil W, Nicholson G, Fiedler HP, Süssmuth RD.

J Antibiot (Tokyo). 2009 Sep;62(9):513-8. doi: 10.1038/ja.2009.64. Epub 2009 Jul 17.

PMID:
19609293
17.
18.

New geldanamycin analogs from Streptomyces hygroscopicus.

Wu CZ, Jang JH, Ahn JS, Hong YS.

J Microbiol Biotechnol. 2012 Nov;22(11):1478-81.

19.

Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.

Li T, Ni S, Jia C, Wang H, Sun G, Wu L, Gan M, Shan G, He W, Lin L, Zhou H, Wang Y.

J Nat Prod. 2012 Aug 24;75(8):1480-4. doi: 10.1021/np3001738. Epub 2012 Jul 31.

PMID:
22849774
20.

Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.

Lin L, Ni S, Wu L, Wang Y, Wang Y, Tao P, He W, Wang X.

Biosci Biotechnol Biochem. 2011;75(10):2042-5. Epub 2011 Oct 7.

Supplemental Content

Support Center