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Items: 1 to 20 of 266

1.

Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.

Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Akerman KE, Lindstedt K, Pertovaara A.

Pharmacol Res. 2012 Jan;65(1):149-58. doi: 10.1016/j.phrs.2011.10.006. Epub 2011 Nov 23.

PMID:
22133672
2.

Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy.

Koivisto A, Pertovaara A.

Scand J Pain. 2013 Jul 1;4(3):129-136. doi: 10.1016/j.sjpain.2012.11.001.

PMID:
29913916
3.

Activation of transient receptor potential ankyrin 1 by eugenol.

Chung G, Im ST, Kim YH, Jung SJ, Rhyu MR, Oh SB.

Neuroscience. 2014 Mar 7;261:153-60. doi: 10.1016/j.neuroscience.2013.12.047. Epub 2013 Dec 30.

PMID:
24384226
4.

Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat.

Wei H, Chapman H, Saarnilehto M, Kuokkanen K, Koivisto A, Pertovaara A.

Neuropharmacology. 2010 Mar;58(3):578-84. doi: 10.1016/j.neuropharm.2009.12.001. Epub 2009 Dec 29.

PMID:
20004676
5.

Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A.

Wei H, Saarnilehto M, Falck L, Viisanen H, Lasierra M, Koivisto A, Pertovaara A.

J Physiol Pharmacol. 2013 Jun;64(3):331-40.

6.

Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors.

Dunham JP, Leith JL, Lumb BM, Donaldson LF.

Neuroscience. 2010 Feb 17;165(4):1412-9. doi: 10.1016/j.neuroscience.2009.11.065. Epub 2009 Dec 1.

7.

Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels.

Oguri G, Nakajima T, Yamamoto Y, Takano N, Tanaka T, Kikuchi H, Morita T, Nakamura F, Yamasoba T, Komuro I.

Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1339-52. doi: 10.1152/ajpheart.01021.2013. Epub 2014 Aug 29.

8.

Towards Development of a Dermal Pain Model: In Vitro Activation of Rat and Human Transient Receptor Potential Ankyrin Repeat 1 and Safe Dermal Injection of o-Chlorobenzylidene Malononitrile to Rat.

Annas A, Berg AL, Nyman E, Meijer T, Lundgren V, Franzén B, Ståhle L.

Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):375-82. doi: 10.1111/bcpt.12427. Epub 2015 Jul 7.

9.

Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels.

Huang Q, Chen Y, Gong N, Wang YX.

Metabolism. 2016 Apr;65(4):463-74. doi: 10.1016/j.metabol.2015.12.002. Epub 2015 Dec 17.

PMID:
26975538
10.
11.

Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies.

Eberhardt MJ, Filipovic MR, Leffler A, de la Roche J, Kistner K, Fischer MJ, Fleming T, Zimmermann K, Ivanovic-Burmazovic I, Nawroth PP, Bierhaus A, Reeh PW, Sauer SK.

J Biol Chem. 2012 Aug 17;287(34):28291-306. doi: 10.1074/jbc.M111.328674. Epub 2012 Jun 27.

12.

TRPA1 and substance P mediate colitis in mice.

Engel MA, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović MR, Izydorczyk I, Eberhardt M, Kichko TI, Mueller-Tribbensee SM, Khalil M, Siklosi N, Nau C, Ivanović-Burmazović I, Neuhuber WL, Becker C, Neurath MF, Reeh PW.

Gastroenterology. 2011 Oct;141(4):1346-58. doi: 10.1053/j.gastro.2011.07.002. Epub 2011 Jul 18.

PMID:
21763243
13.

TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.

Anand U, Otto WR, Facer P, Zebda N, Selmer I, Gunthorpe MJ, Chessell IP, Sinisi M, Birch R, Anand P.

Neurosci Lett. 2008 Jun 20;438(2):221-7. doi: 10.1016/j.neulet.2008.04.007. Epub 2008 Apr 8.

PMID:
18456404
14.

Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain.

Wang S, Zhai C, Zhang Y, Yu Y, Zhang Y, Ma L, Li S, Qiao Y.

Molecules. 2016 Aug 29;21(9). pii: E1145. doi: 10.3390/molecules21091145.

15.

Sustained TRPA1 activation in vivo.

Koivisto A.

Acta Physiol (Oxf). 2012 Feb;204(2):248-54. doi: 10.1111/j.1748-1716.2011.02318.x. Epub 2011 May 28. Review.

PMID:
21518269
16.

Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization.

Barrière DA, Rieusset J, Chanteranne D, Busserolles J, Chauvin MA, Chapuis L, Salles J, Dubray C, Morio B.

Pain. 2012 Mar;153(3):553-61. doi: 10.1016/j.pain.2011.11.019. Epub 2011 Dec 15.

PMID:
22177224
17.

The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor.

Suzuki H, Hatano N, Muraki Y, Itoh Y, Kimura S, Hayashi H, Onozaki K, Ohi Y, Haji A, Muraki K.

Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94. doi: 10.1152/ajpcell.00182.2013. Epub 2014 Jun 18.

18.

Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels.

Bang S, Yoo S, Yang TJ, Cho H, Hwang SW.

Pain. 2011 May;152(5):1156-64. doi: 10.1016/j.pain.2011.01.044. Epub 2011 Feb 24.

PMID:
21353389
19.

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.

Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V.

Neuropharmacology. 2015 Jun;93:294-307. doi: 10.1016/j.neuropharm.2015.02.018. Epub 2015 Feb 25.

PMID:
25724085
20.

Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.

Copeland KW, Boezio AA, Cheung E, Lee J, Olivieri P, Schenkel LB, Wan Q, Wang W, Wells MC, Youngblood B, Gavva NR, Lehto SG, Geuns-Meyer S.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3464-8. doi: 10.1016/j.bmcl.2014.05.069. Epub 2014 Jun 6.

PMID:
24953819

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