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Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.

Ollinger J, O'Malley T, Kesicki EA, Odingo J, Parish T.

J Bacteriol. 2012 Feb;194(3):663-8. doi: 10.1128/JB.06142-11. Epub 2011 Nov 28.


The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.

Leodolter J, Warweg J, Weber-Ban E.

PLoS One. 2015 May 1;10(5):e0125345. doi: 10.1371/journal.pone.0125345. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0131132.


Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.

Personne Y, Brown AC, Schuessler DL, Parish T.

PLoS One. 2013;8(4):e60228. doi: 10.1371/journal.pone.0060228. Epub 2013 Apr 1.


Acyl depsipeptide (ADEP) resistance in Streptomyces.

Gominet M, Seghezzi N, Mazodier P.

Microbiology. 2011 Aug;157(Pt 8):2226-34. doi: 10.1099/mic.0.048454-0. Epub 2011 Jun 2.


Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.

Schmitz KR, Sauer RT.

Mol Microbiol. 2014 Aug;93(4):617-28. doi: 10.1111/mmi.12694. Epub 2014 Jul 13.


Distinct clpP genes control specific adaptive responses in Bacillus thuringiensis.

Fedhila S, Msadek T, Nel P, Lereclus D.

J Bacteriol. 2002 Oct;184(20):5554-62.


Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2.

Benaroudj N, Raynal B, Miot M, Ortiz-Lombardia M.

BMC Biochem. 2011 Dec 1;12:61. doi: 10.1186/1471-2091-12-61.


Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.

Raju RM, Unnikrishnan M, Rubin DH, Krishnamoorthy V, Kandror O, Akopian TN, Goldberg AL, Rubin EJ.

PLoS Pathog. 2012 Feb;8(2):e1002511. doi: 10.1371/journal.ppat.1002511. Epub 2012 Feb 16.


Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.

Li M, Kandror O, Akopian T, Dharkar P, Wlodawer A, Maurizi MR, Goldberg AL.

J Biol Chem. 2016 Apr 1;291(14):7465-76. doi: 10.1074/jbc.M115.700344. Epub 2016 Feb 8.


The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease.

Kirstein J, Hoffmann A, Lilie H, Schmidt R, Rübsamen-Waigmann H, Brötz-Oesterhelt H, Mogk A, Turgay K.

EMBO Mol Med. 2009 Apr;1(1):37-49. doi: 10.1002/emmm.200900002.


The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.

Akopian T, Kandror O, Raju RM, Unnikrishnan M, Rubin EJ, Goldberg AL.

EMBO J. 2012 Mar 21;31(6):1529-41. doi: 10.1038/emboj.2012.5. Epub 2012 Jan 27.


Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system.

Farrand AJ, Reniere ML, Ingmer H, Frees D, Skaar EP.

J Bacteriol. 2013 Nov;195(22):5041-50. doi: 10.1128/JB.00505-13. Epub 2013 Aug 30.


Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.

Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H.

Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1.


Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus.

Feng J, Michalik S, Varming AN, Andersen JH, Albrecht D, Jelsbak L, Krieger S, Ohlsen K, Hecker M, Gerth U, Ingmer H, Frees D.

J Proteome Res. 2013 Feb 1;12(2):547-58. doi: 10.1021/pr300394r. Epub 2013 Jan 8.


Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair.

Michel A, Agerer F, Hauck CR, Herrmann M, Ullrich J, Hacker J, Ohlsen K.

J Bacteriol. 2006 Aug;188(16):5783-96.


The clpP multigene family for the ATP-dependent Clp protease in the cyanobacterium Synechococcus.

Schelin J, Lindmark F, Clarke AK.

Microbiology. 2002 Jul;148(Pt 7):2255-65.


Bacterial caseinolytic proteases as novel targets for antibacterial treatment.

Brötz-Oesterhelt H, Sass P.

Int J Med Microbiol. 2014 Jan;304(1):23-30. doi: 10.1016/j.ijmm.2013.09.001. Epub 2013 Sep 4. Review.


Contribution of conserved ATP-dependent proteases of Campylobacter jejuni to stress tolerance and virulence.

Cohn MT, Ingmer H, Mulholland F, Jørgensen K, Wells JM, Brøndsted L.

Appl Environ Microbiol. 2007 Dec;73(24):7803-13. Epub 2007 Oct 12.


Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.

Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL.

J Biol Chem. 2015 Apr 24;290(17):11008-20. doi: 10.1074/jbc.M114.625640. Epub 2015 Mar 10.

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