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Items: 1 to 20 of 104

1.

CYP2C76 non-synonymous variants in cynomolgus and rhesus macaques.

Uehara S, Murayama N, Yamazaki H, Uno Y.

Drug Metab Pharmacokinet. 2012;27(3):344-8. Epub 2011 Nov 29.

2.

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

Uno Y, Matsushita A, Osada N, Uehara S, Kohara S, Nagata R, Fukuzaki K, Utoh M, Murayama N, Yamazaki H.

Drug Metab Dispos. 2010 Feb;38(2):209-14. doi: 10.1124/dmd.109.029710. Epub 2009 Nov 12.

3.

CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques.

Uno Y, Matsushita A, Shukuya M, Matsumoto Y, Murayama N, Yamazaki H.

Biochem Pharmacol. 2014 Sep 15;91(2):242-8. doi: 10.1016/j.bcp.2014.07.004. Epub 2014 Jul 15.

PMID:
25036290
4.

CYP2D44 polymorphisms in cynomolgus and rhesus macaques.

Uno Y, Uehara S, Kohara S, Osada N, Murayama N, Yamazaki H.

Mol Biol Rep. 2015 Jul;42(7):1149-55. doi: 10.1007/s11033-015-3863-0. Epub 2015 Feb 15.

PMID:
25682269
5.

Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes.

Uno Y, Fujino H, Iwasaki K, Utoh M.

Curr Drug Metab. 2010 Feb;11(2):142-52. Review.

PMID:
20359284
6.

Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.

Uno Y, Uehara S, Kohara S, Murayama N, Yamazaki H.

Drug Metab Dispos. 2014 Sep;42(9):1407-10. doi: 10.1124/dmd.114.059220. Epub 2014 Jul 1.

7.

Expression profile of hepatic genes in cynomolgus macaques bred in Cambodia, China, and Indonesia: implications for cytochrome P450 genes.

Ise R, Nakanishi Y, Kohara S, Yamashita H, Yoshikawa T, Iwasaki K, Nagata R, Fukuzaki K, Utoh M, Nakamura C, Yamazaki H, Uno Y.

Drug Metab Pharmacokinet. 2012;27(3):307-16. Epub 2011 Dec 13.

8.

Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.

Uno Y, Matsushita A, Murayama N, Yamazaki H.

Drug Metab Pharmacokinet. 2015 Feb;30(1):130-2. doi: 10.1016/j.dmpk.2014.10.002. Epub 2014 Oct 19.

PMID:
25760542
9.

Single nucleotide polymorphisms (SNPs) are highly conserved in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques.

Street SL, Kyes RC, Grant R, Ferguson B.

BMC Genomics. 2007 Dec 31;8:480. doi: 10.1186/1471-2164-8-480.

10.

Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques.

Uno Y, Utoh M, Iwasaki K.

Drug Metab Pharmacokinet. 2014;29(5):427-30. Epub 2014 May 6.

12.

CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.

Uno Y, Fujino H, Kito G, Kamataki T, Nagata R.

Mol Pharmacol. 2006 Aug;70(2):477-86. Epub 2006 Apr 28.

13.

CYP1B1 is polymorphic in cynomolgus and rhesus macaques.

Uno Y, Matsushita A, Yamazaki H.

J Vet Med Sci. 2011 Sep;73(9):1229-31. Epub 2011 May 6.

14.

CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: The potential role of CYP2C76 in early embryogenesis.

Koyama S, Fukuda K, Watanabe S, Matsushita A, Tsuchiya H, Fujinami N, Kohara S, Murayama N, Nagano M, Yamazaki H, Fukuzaki K, Uno Y, Hosoi Y.

Drug Metab Pharmacokinet. 2017 Feb;32(1):112-115. doi: 10.1016/j.dmpk.2016.10.411. Epub 2016 Oct 27.

PMID:
28153493
15.

Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity.

Schwarz D, Kisselev P, Schunck WH, Chernogolov A, Boidol W, Cascorbi I, Roots I.

Pharmacogenetics. 2000 Aug;10(6):519-30.

PMID:
10975606
16.

Single-nucleotide polymorphisms reveal patterns of allele sharing across the species boundary between rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaques.

Satkoski Trask JA, Garnica WT, Smith DG, Houghton P, Lerche N, Kanthaswamy S.

Am J Primatol. 2013 Feb;75(2):135-44. doi: 10.1002/ajp.22091. Epub 2012 Nov 15.

17.

Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase.

Hosaka S, Murayama N, Satsukawa M, Shimizu M, Uehara S, Fujino H, Iwasaki K, Iwano S, Uno Y, Yamazaki H.

Drug Metab Dispos. 2015 Jan;43(1):27-33. doi: 10.1124/dmd.114.061275. Epub 2014 Oct 15.

18.

Cytochrome P450 metabolic activities in the small intestine of cynomolgus macaques bred in Cambodia, China, and Indonesia.

Nakanishi Y, Yamashita H, Yoshikawa T, Tominaga T, Nojiri K, Sunaga Y, Muneoka A, Iwasaki K, Utoh M, Nakamura C, Yamazaki H, Uno Y.

Drug Metab Pharmacokinet. 2013;28(6):510-3. Epub 2013 May 7.

19.

Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome.

Higashino A, Sakate R, Kameoka Y, Takahashi I, Hirata M, Tanuma R, Masui T, Yasutomi Y, Osada N.

Genome Biol. 2012 Jul 2;13(7):R58. doi: 10.1186/gb-2012-13-7-r58.

20.

A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism.

Uno Y, Sakuraba H, Uehara S, Kumano T, Matsuno K, Nakamura C, Kito G, Kamataki T, Nagata R.

Drug Metab Dispos. 2009 Jan;37(1):14-7. doi: 10.1124/dmd.108.023622. Epub 2008 Sep 29.

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