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Items: 1 to 20 of 165

1.

The impact of glycosylation on monoclonal antibody conformation and stability.

Zheng K, Bantog C, Bayer R.

MAbs. 2011 Nov-Dec;3(6):568-76. doi: 10.4161/mabs.3.6.17922. Epub 2011 Nov 1.

2.

Influence of glycosylation pattern on the molecular properties of monoclonal antibodies.

Zheng K, Yarmarkovich M, Bantog C, Bayer R, Patapoff TW.

MAbs. 2014 May-Jun;6(3):649-58. doi: 10.4161/mabs.28588. Epub 2014 Mar 24.

3.

Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry.

Ghirlando R, Lund J, Goodall M, Jefferis R.

Immunol Lett. 1999 May 3;68(1):47-52.

PMID:
10397155
4.

Isolation and characterization of IgG1 with asymmetrical Fc glycosylation.

Ha S, Ou Y, Vlasak J, Li Y, Wang S, Vo K, Du Y, Mach A, Fang Y, Zhang N.

Glycobiology. 2011 Aug;21(8):1087-96. doi: 10.1093/glycob/cwr047. Epub 2011 Apr 5.

PMID:
21470983
5.

The impact of N-glycosylation on conformation and stability of immunoglobulin Y from egg yolk.

Sheng L, He Z, Chen J, Liu Y, Ma M, Cai Z.

Int J Biol Macromol. 2017 Mar;96:129-136. doi: 10.1016/j.ijbiomac.2016.12.043. Epub 2016 Dec 14.

PMID:
27988289
6.

Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F.

Mamedov T, Ghosh A, Jones RM, Mett V, Farrance CE, Musiychuk K, Horsey A, Yusibov V.

Plant Biotechnol J. 2012 Sep;10(7):773-82. doi: 10.1111/j.1467-7652.2012.00694.x. Epub 2012 Apr 23.

7.

Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells.

Hills AE, Patel A, Boyd P, James DC.

Biotechnol Bioeng. 2001 Oct 20;75(2):239-51.

PMID:
11536148
8.

Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation.

Gandhi S, Ren D, Xiao G, Bondarenko P, Sloey C, Ricci MS, Krishnan S.

Pharm Res. 2012 Jan;29(1):209-24. doi: 10.1007/s11095-011-0536-0. Epub 2011 Aug 16.

PMID:
21845507
9.

Deglycosylation of ovalbumin prohibits formation of a heat-stable conformer.

de Groot J, Kosters HA, de Jongh HH.

Biotechnol Bioeng. 2007 Jul 1;97(4):735-41.

PMID:
17154314
10.

The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms.

Mimura Y, Church S, Ghirlando R, Ashton PR, Dong S, Goodall M, Lund J, Jefferis R.

Mol Immunol. 2000 Aug-Sep;37(12-13):697-706.

PMID:
11275255
11.

Effect of pH, temperature, and salt on the stability of Escherichia coli- and Chinese hamster ovary cell-derived IgG1 Fc.

Li CH, Narhi LO, Wen J, Dimitrova M, Wen ZQ, Li J, Pollastrini J, Nguyen X, Tsuruda T, Jiang Y.

Biochemistry. 2012 Dec 18;51(50):10056-65. doi: 10.1021/bi300702e. Epub 2012 Dec 4.

PMID:
23078371
12.

Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography-mass spectrometry peptide mapping.

Bongers J, Devincentis J, Fu J, Huang P, Kirkley DH, Leister K, Liu P, Ludwig R, Rumney K, Tao L, Wu W, Russell RJ.

J Chromatogr A. 2011 Nov 11;1218(45):8140-9. doi: 10.1016/j.chroma.2011.08.089. Epub 2011 Sep 3.

PMID:
21978954
13.

Glycosylation of bombesin receptors: characterization, effect on binding, and G-protein coupling.

Kusui T, Benya RV, Battey JF, Jensen RT.

Biochemistry. 1994 Nov 8;33(44):12968-80.

PMID:
7947701
14.
15.

The N-linked oligosaccharide at Fc gamma RIIIa Asn-45: an inhibitory element for high Fc gamma RIIIa binding affinity to IgG glycoforms lacking core fucosylation.

Shibata-Koyama M, Iida S, Okazaki A, Mori K, Kitajima-Miyama K, Saitou S, Kakita S, Kanda Y, Shitara K, Kato K, Satoh M.

Glycobiology. 2009 Feb;19(2):126-34. doi: 10.1093/glycob/cwn110. Epub 2008 Oct 24.

16.

Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress.

Ito T, Tsumoto K.

Protein Sci. 2013 Nov;22(11):1542-51. doi: 10.1002/pro.2340. Epub 2013 Sep 30.

17.

Activity enhancement of a lung cancer-associated human monoclonal antibody HB4C5 by N-deglycosylation.

Kato M, Mochizuki K, Hashizume S, Tachibana H, Shirahata S, Murakami H.

Hum Antibodies Hybridomas. 1993 Jan;4(1):9-14.

PMID:
8431558
18.

Methods to determine the level of afucosylation in recombinant monoclonal antibodies.

Shen Y, Liu H.

Anal Chem. 2010 Dec 1;82(23):9871-7. doi: 10.1021/ac102332f. Epub 2010 Nov 8.

PMID:
21058685
19.

The way forward, enhanced characterization of therapeutic antibody glycosylation: comparison of three level mass spectrometry-based strategies.

Wagner-Rousset E, Bednarczyk A, Bussat MC, Colas O, Corvaïa N, Schaeffer C, Van Dorsselaer A, Beck A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):23-37. doi: 10.1016/j.jchromb.2008.03.032. Epub 2008 Apr 15.

PMID:
18672411
20.

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.

Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD.

MAbs. 2015;7(1):84-95. doi: 10.4161/19420862.2014.985494.

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