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Items: 1 to 20 of 102


Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.

Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, D'Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-5. doi: 10.1038/nsmb.2189.


A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.

Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O.

Nat Genet. 2009 Aug;41(8):891-8. doi: 10.1038/ng.420. Epub 2009 Jul 20.


Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.

Liu Y, Bertram CC, Shi Q, Zinkel SS.

Cell Death Differ. 2011 May;18(5):841-52. doi: 10.1038/cdd.2010.151. Epub 2010 Nov 26.


Myc induced replicative stress response: How to cope with it and exploit it.

Rohban S, Campaner S.

Biochim Biophys Acta. 2015 May;1849(5):517-24. doi: 10.1016/j.bbagrm.2014.04.008. Epub 2014 Apr 13. Review.


Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells.

Furusawa Y, Iizumi T, Fujiwara Y, Hassan MA, Tabuchi Y, Nomura T, Kondo T.

Ultrason Sonochem. 2012 Nov;19(6):1246-51. doi: 10.1016/j.ultsonch.2012.04.003. Epub 2012 Apr 19.


Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

Fokas E, Prevo R, Pollard JR, Reaper PM, Charlton PA, Cornelissen B, Vallis KA, Hammond EM, Olcina MM, Gillies McKenna W, Muschel RJ, Brunner TB.

Cell Death Dis. 2012 Dec 6;3:e441. doi: 10.1038/cddis.2012.181.


Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.

Maclean KH, Dorsey FC, Cleveland JL, Kastan MB.

J Clin Invest. 2008 Jan;118(1):79-88. Erratum in: J Clin Invest. 2008 Apr;118(4):1584.


An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.

López-Contreras AJ, Gutierrez-Martinez P, Specks J, Rodrigo-Perez S, Fernandez-Capetillo O.

J Exp Med. 2012 Mar 12;209(3):455-61. doi: 10.1084/jem.20112147. Epub 2012 Feb 27.


APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

Willis J, Patel Y, Lentz BL, Yan S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110. Epub 2013 Jun 10.


Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ.

Genes Dev. 2000 Jun 15;14(12):1448-59.


Inhibition of ATR-dependent signaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo.

Wang HC, Lee AY, Chou WC, Wu CC, Tseng CN, Liu KY, Lin WL, Chang FR, Chuang DW, Hunyadi A, Wu YC.

Mol Cancer Ther. 2012 Jul;11(7):1443-53. doi: 10.1158/1535-7163.MCT-11-0921. Epub 2012 Apr 24.


Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.


ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.

Pabla N, Huang S, Mi QS, Daniel R, Dong Z.

J Biol Chem. 2008 Mar 7;283(10):6572-83. Epub 2007 Dec 27. Erratum in: J Biol Chem. 2008 May 30;283(22):15512.


Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.

Hong S, Pusapati RV, Powers JT, Johnson DG.

Cell Cycle. 2006 Apr;5(8):801-3. Epub 2006 Apr 17.


Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.

J Biol Chem. 2005 Jan 14;280(2):1186-92. Epub 2004 Nov 8.


ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1446-51. Epub 2006 Jan 23.


Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs.

Toledo LI, Murga M, Fernandez-Capetillo O.

Mol Oncol. 2011 Aug;5(4):368-73. doi: 10.1016/j.molonc.2011.07.002. Epub 2011 Jul 28. Review.


Study of the DNA damage checkpoint using Xenopus egg extracts.

Willis J, DeStephanis D, Patel Y, Gowda V, Yan S.

J Vis Exp. 2012 Nov 5;(69):e4449. doi: 10.3791/4449.


Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells.

Jirmanova L, Bulavin DV, Fornace AJ Jr.

Cell Cycle. 2005 Oct;4(10):1428-34. Epub 2005 Oct 26.


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