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Items: 1 to 20 of 103


Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association.

Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG.

Sci Signal. 2011 Nov 22;4(200):ra79. doi: 10.1126/scisignal.2002223.


Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.

Chan P, Gabay M, Wright FA, Tall GG.

J Biol Chem. 2011 Jun 3;286(22):19932-42. doi: 10.1074/jbc.M110.163675. Epub 2011 Apr 5.


Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits.

Chan P, Thomas CJ, Sprang SR, Tall GG.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3794-9. doi: 10.1073/pnas.1220943110. Epub 2013 Feb 19.


Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf).

Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG.

J Biol Chem. 2011 Jan 28;286(4):2625-35. doi: 10.1074/jbc.M110.178897. Epub 2010 Nov 29.


Ric-8 regulation of heterotrimeric G proteins.

Tall GG.

J Recept Signal Transduct Res. 2013 Jun;33(3):139-43. doi: 10.3109/10799893.2013.763828. Epub 2013 Feb 6. Review.


Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.

Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY.

J Biol Chem. 2011 Sep 2;286(35):31055-61. doi: 10.1074/jbc.M111.253427. Epub 2011 Jul 19.


Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

Kant R, Zeng B, Thomas CJ, Bothner B, Sprang SR.

Elife. 2016 Dec 23;5. pii: e19238. doi: 10.7554/eLife.19238.


The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.

Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR.

PLoS One. 2011;6(8):e23197. doi: 10.1371/journal.pone.0023197. Epub 2011 Aug 11.


Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.

Thomas CJ, Tall GG, Adhikari A, Sprang SR.

J Biol Chem. 2008 Aug 22;283(34):23150-60. doi: 10.1074/jbc.M802422200. Epub 2008 Jun 9.


Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM.

J Biol Chem. 2013 Feb 1;288(5):3003-15. doi: 10.1074/jbc.M112.418467. Epub 2012 Dec 4.


Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.

Tall GG, Krumins AM, Gilman AG.

J Biol Chem. 2003 Mar 7;278(10):8356-62. Epub 2002 Dec 30.


G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.

Vellano CP, Maher EM, Hepler JR, Blumer JB.

J Biol Chem. 2011 Nov 4;286(44):38659-69. doi: 10.1074/jbc.M111.274928. Epub 2011 Aug 31.


Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.

Black LA, Thomas CJ, Nix GN, Terwilliger MC, Sprang SR, Ross JBA.

Biophys J. 2016 Aug 23;111(4):722-731. doi: 10.1016/j.bpj.2016.07.021.


Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.

Chishiki K, Kamakura S, Yuzawa S, Hayase J, Sumimoto H.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):414-9. doi: 10.1016/j.bbrc.2013.04.103. Epub 2013 May 9.


The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.

Van Eps N, Thomas CJ, Hubbell WL, Sprang SR.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1404-9. doi: 10.1073/pnas.1423878112. Epub 2015 Jan 20.


Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).

Tse MK, Morris CJ, Zhang M, Wong YH.

Mol Cell Biochem. 2015 Mar;401(1-2):27-38. doi: 10.1007/s11010-014-2289-7. Epub 2014 Dec 6.


Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells.

Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV.

Mol Pharmacol. 2005 Jul;68(1):129-36. Epub 2005 Mar 31.


The G protein α chaperone Ric-8 as a potential therapeutic target.

Papasergi MM, Patel BR, Tall GG.

Mol Pharmacol. 2015 Jan;87(1):52-63. doi: 10.1124/mol.114.094664. Epub 2014 Oct 15. Review.


B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency.

Boularan C, Hwang IY, Kamenyeva O, Park C, Harrison K, Huang Z, Kehrl JH.

J Immunol. 2015 Sep 1;195(5):2090-102. doi: 10.4049/jimmunol.1500523. Epub 2015 Jul 31.

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