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Items: 1 to 20 of 97

1.

Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.

Bartl J, Scholz CJ, Hinterberger M, Jungwirth S, Wichart I, Rainer MK, Kneitz S, Danielczyk W, Tragl KH, Fischer P, Riederer P, Grünblatt E.

BMC Med Genet. 2011 Nov 22;12:151. doi: 10.1186/1471-2350-12-151.

2.

Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes.

Rudovich N, Pivovarova O, Fisher E, Fischer-Rosinsky A, Spranger J, Möhlig M, Schulze MB, Boeing H, Pfeiffer AF.

J Mol Med (Berl). 2009 Nov;87(11):1145-51. doi: 10.1007/s00109-009-0540-6. Epub 2009 Oct 7.

PMID:
19809796
3.

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L.

Neurology. 2004 Jul 27;63(2):241-5.

PMID:
15277615
4.

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.

Ertekin-Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen RC, Graff-Radford N, Younkin SG.

Hum Mutat. 2004 Apr;23(4):334-42.

PMID:
15024728
5.

Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels.

Gu HF, Efendic S, Nordman S, Ostenson CG, Brismar K, Brookes AJ, Prince JA.

Diabetes. 2004 Aug;53(8):2137-42.

6.

Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.

Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M.

J Med Genet. 2007 Sep;44(9):606-8. Epub 2007 May 11.

7.

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels.

Reitz C, Cheng R, Schupf N, Lee JH, Mehta PD, Rogaeva E, St George-Hyslop P, Mayeux R.

Neurobiol Aging. 2012 Jan;33(1):199.e13-7. doi: 10.1016/j.neurobiolaging.2010.07.005. Epub 2010 Aug 17.

8.

Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis.

Cheng H, Wang L, Shi T, Shang Y, Jiang L.

Int J Neurosci. 2015 May;125(5):328-35. doi: 10.3109/00207454.2014.941440. Epub 2014 Sep 16.

PMID:
25105907
9.

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.

Boussaha M, Hannequin D, Verpillat P, Brice A, Frebourg T, Campion D.

Neurosci Lett. 2002 Aug 23;329(1):121-3.

PMID:
12161276
10.

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.

Am J Pathol. 2004 Apr;164(4):1425-34.

11.

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI.

Diabetes. 2003 May;52(5):1300-5.

12.

Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease.

Edland SD.

J Mol Neurosci. 2004;23(3):213-7.

PMID:
15181249
13.

Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease.

Wang S, He F, Wang Y.

J Geriatr Psychiatry Neurol. 2015 Jun;28(2):94-8. doi: 10.1177/0891988714554707. Epub 2014 Nov 20.

PMID:
25414272
14.

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.

Sakai A, Ujike H, Nakata K, Takehisa Y, Imamura T, Uchida N, Kanzaki A, Yamamoto M, Fujisawa Y, Okumura K, Kuroda S.

Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15;125B(1):87-91.

PMID:
14755451
15.

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

Qiu WQ, Folstein MF.

Neurobiol Aging. 2006 Feb;27(2):190-8. Epub 2005 Feb 17. Review.

PMID:
16399206
16.

Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.

Zuo X, Jia J.

Brain Res. 2009 Jan 16;1249:1-8. doi: 10.1016/j.brainres.2008.10.034. Epub 2008 Oct 28.

PMID:
18996360
17.

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

Abraham R, Myers A, Wavrant-DeVrieze F, Hamshere ML, Thomas HV, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ, Jones L.

Hum Genet. 2001 Dec;109(6):646-52. Epub 2001 Nov 1.

PMID:
11810277
18.

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.

Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P, Moore P, Bryden L, Myers A, Doil LM, Tacey KM, Gibson AM, McKeith IG, Perry RH, Morris CM, Thal L, Morris JC, O'Donovan MC, Lovestone S, Grupe A, Hardy J, Owen MJ, Williams J, Goate A.

Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):62-8.

PMID:
15858813
19.

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.

20.

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease.

Carrasquillo MM, Belbin O, Zou F, Allen M, Ertekin-Taner N, Ansari M, Wilcox SL, Kashino MR, Ma L, Younkin LH, Younkin SG, Younkin CS, Dincman TA, Howard ME, Howell CC, Stanton CM, Watson CM, Crump M, Vitart V, Hayward C, Hastie ND, Rudan I, Campbell H, Polasek O, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Kehoe PG, Mann DM, Smith AD, Beaumont H, Warden D, Holmes C, Heun R, Kölsch H, Kalsheker N, Pankratz VS, Dickson DW, Graff-Radford NR, Petersen RC, Wright AF, Younkin SG, Morgan K.

PLoS One. 2010 Jan 19;5(1):e8764. doi: 10.1371/journal.pone.0008764.

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