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Items: 1 to 20 of 109

1.

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY.

J Mol Med (Berl). 2012 May;90(5):575-85. doi: 10.1007/s00109-011-0834-3. Epub 2011 Nov 22.

2.

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.

Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW.

Aging Cell. 2016 Feb;15(1):28-38. doi: 10.1111/acel.12405. Epub 2015 Oct 13.

3.

Novel culture technique involving an histone deacetylase inhibitor reduces the marginal islet mass to correct streptozotocin-induced diabetes.

Shin JS, Min BH, Lim JY, Kim BK, Han HJ, Yoon KH, Kim SJ, Park CG.

Cell Transplant. 2011;20(9):1321-32. doi: 10.3727/096368910X557146. Epub 2011 Feb 3.

PMID:
21294957
4.

Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.

Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk MM, Schneyer A.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E587-96. doi: 10.1152/ajpendo.00177.2012. Epub 2012 Jun 26.

5.

Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance.

Moon MK, Jeong IK, Jung Oh T, Ahn HY, Kim HH, Park YJ, Jang HC, Park KS.

J Endocrinol. 2015 Jul;226(1):35-42. doi: 10.1530/JOE-14-0714. Epub 2015 May 13.

6.

Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism.

Shimodahira M, Fujimoto S, Mukai E, Nakamura Y, Nishi Y, Sasaki M, Sato Y, Sato H, Hosokawa M, Nagashima K, Seino Y, Inagaki N.

J Endocrinol. 2010 Jan;204(1):37-46. doi: 10.1677/JOE-09-0216. Epub 2009 Oct 7.

7.

The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.

Bermudez-Silva FJ, Romero-Zerbo SY, Haissaguerre M, Ruz-Maldonado I, Lhamyani S, El Bekay R, Tabarin A, Marsicano G, Cota D.

Dis Model Mech. 2016 Jan;9(1):51-61. doi: 10.1242/dmm.020750. Epub 2015 Nov 12.

8.

A novel dipeptidyl peptidase IV inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing β-cell replication and neogenesis.

Cho JM, Jang HW, Cheon H, Jeong YT, Kim DH, Lim YM, Choi SH, Yang EK, Shin CY, Son MH, Kim SH, Kim HJ, Lee MS.

Diabetes Res Clin Pract. 2011 Jan;91(1):72-9. doi: 10.1016/j.diabres.2010.10.012. Epub 2010 Nov 18.

PMID:
21093089
9.

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE.

Aging Cell. 2013 Aug;12(4):712-8. doi: 10.1111/acel.12097. Epub 2013 Jun 7.

10.

Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance.

Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S.

PLoS One. 2014 Jan 13;9(1):e84725. doi: 10.1371/journal.pone.0084725. eCollection 2014.

11.

Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter.

Annerén C, Welsh M, Jansson L.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1183-90. Epub 2006 Dec 19.

PMID:
17179392
12.

Pancreatic Islet APJ Deletion Reduces Islet Density and Glucose Tolerance in Mice.

Han S, Englander EW, Gomez GA, Rastellini C, Quertermous T, Kundu RK, Greeley GH Jr.

Endocrinology. 2015 Jul;156(7):2451-60. doi: 10.1210/en.2014-1631. Epub 2015 May 12.

PMID:
25965959
13.

Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells.

Ropero AB, Alonso-Magdalena P, Soriano S, Juan-Picó P, Roepke TA, Kelly MJ, Nadal Á.

PLoS One. 2012;7(4):e34650. doi: 10.1371/journal.pone.0034650. Epub 2012 Apr 10. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/c1da4989-c6e8-43c2-9a8b-1462af83ae5e.

14.

Telomerase deficiency impairs glucose metabolism and insulin secretion.

Kuhlow D, Florian S, von Figura G, Weimer S, Schulz N, Petzke KJ, Zarse K, Pfeiffer AF, Rudolph KL, Ristow M.

Aging (Albany NY). 2010 Oct;2(10):650-8.

15.

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR.

Nat Genet. 2002 May;31(1):111-5. Epub 2002 Apr 1.

PMID:
11923875
16.

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.

Bahrami J, Longuet C, Baggio LL, Li K, Drucker DJ.

Gastroenterology. 2010 Sep;139(3):857-68. doi: 10.1053/j.gastro.2010.05.006. Epub 2010 Jun 11.

PMID:
20546737
18.

The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice.

Noh JR, Hwang JH, Kim YH, Kim KS, Gang GT, Kim SW, Kim DK, Shong M, Lee IK, Choi HS, Lee CH.

Int J Biochem Cell Biol. 2013 Aug;45(8):1538-45. doi: 10.1016/j.biocel.2013.05.004. Epub 2013 May 13.

PMID:
23680671
19.

Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.

Yang P, Zhao Y, Zhao L, Yuan J, Chen Y, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Sci Rep. 2015 Oct 9;5:14959. doi: 10.1038/srep14959.

20.

Rapamycin impairs HPD-induced beneficial effects on glucose homeostasis.

Chang GR, Chiu YS, Wu YY, Lin YC, Hou PH, Mao FC.

Br J Pharmacol. 2015 Aug;172(15):3793-804. doi: 10.1111/bph.13168. Epub 2015 Jun 12.

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