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Items: 1 to 20 of 155

1.

Altered strand transfer activity of a multiple-drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutant with a dipeptide fingers domain insertion.

Nguyen LA, Daddacha W, Rigby S, Bambara RA, Kim B.

J Mol Biol. 2012 Jan 13;415(2):248-62. doi: 10.1016/j.jmb.2011.11.014. Epub 2011 Nov 12.

2.

Dynamics of dominance of a dipeptide insertion in reverse transcriptase of HIV-1 from patients subjected to prolonged therapy.

Briones C, Mas A, Gómez-Mariano G, Altisent C, Menéndez-Arias L, Soriano V, Domingo E.

Virus Res. 2000 Jan;66(1):13-26.

PMID:
10653914
3.

HIV-1 reverse transcriptase dissociates during strand transfer.

Muchiri JM, Rigby ST, Nguyen LA, Kim B, Bambara RA.

J Mol Biol. 2011 Sep 23;412(3):354-64. doi: 10.1016/j.jmb.2011.07.055. Epub 2011 Jul 29.

4.

Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer.

Operario DJ, Balakrishnan M, Bambara RA, Kim B.

J Biol Chem. 2006 Oct 27;281(43):32113-21. Epub 2006 Aug 21.

5.
8.

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation.

Quiñones-Mateu ME, Tadele M, Parera M, Mas A, Weber J, Rangel HR, Chakraborty B, Clotet B, Domingo E, Menéndez-Arias L, Martínez MA.

J Virol. 2002 Oct;76(20):10546-52.

9.

Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine.

Meteer JD, Schinazi RF, Mellors JW, Sluis-Cremer N.

Antiviral Res. 2014 Jan;101:62-7. doi: 10.1016/j.antiviral.2013.10.017. Epub 2013 Nov 7.

11.

A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication.

Herzig E, Voronin N, Kucherenko N, Hizi A.

J Virol. 2015 Aug;89(16):8119-29. doi: 10.1128/JVI.00809-15. Epub 2015 May 20.

12.
13.

Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.

Ehteshami M, Beilhartz GL, Scarth BJ, Tchesnokov EP, McCormick S, Wynhoven B, Harrigan PR, Götte M.

J Biol Chem. 2008 Aug 8;283(32):22222-32. doi: 10.1074/jbc.M803521200. Epub 2008 Jun 10.

15.

Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.

Prado JG, Franco S, Matamoros T, Ruiz L, Clotet B, Menéndez-Arias L, Martínez MA, Martinez-Picado J.

Virology. 2004 Aug 15;326(1):103-12.

18.
19.

A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.

Larder BA, Bloor S, Kemp SD, Hertogs K, Desmet RL, Miller V, Sturmer M, Staszewski S, Ren J, Stammers DK, Stuart DI, Pauwels R.

Antimicrob Agents Chemother. 1999 Aug;43(8):1961-7.

20.

Augmentation of human immunodeficiency virus type 1 subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase.

Sato H, Tomita Y, Ebisawa K, Hachiya A, Shibamura K, Shiino T, Yang R, Tatsumi M, Gushi K, Umeyama H, Oka S, Takebe Y, Nagai Y.

J Virol. 2001 Jun;75(12):5604-13.

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