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UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA.

EMBO J. 2011 Nov 15;30(24):4860-73. doi: 10.1038/emboj.2011.401. Erratum in: EMBO J. 2016 Apr 15;35(8):899.


UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.

Vozza A, Parisi G, De Leonardis F, Lasorsa FM, Castegna A, Amorese D, Marmo R, Calcagnile VM, Palmieri L, Ricquier D, Paradies E, Scarcia P, Palmieri F, Bouillaud F, Fiermonte G.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):960-5. doi: 10.1073/pnas.1317400111. Epub 2014 Jan 6.


Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels.

Koziel A, Sobieraj I, Jarmuszkiewicz W.

Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H147-56. doi: 10.1152/ajpheart.00759.2014. Epub 2015 Apr 24.


Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.


Human pluripotent stem cells decouple respiration from energy production.

Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC.

EMBO J. 2011 Dec 14;30(24):4851-2. doi: 10.1038/emboj.2011.436. No abstract available.


Uncoupling protein-2 modulates myocardial excitation-contraction coupling.

Turner JD, Gaspers LD, Wang G, Thomas AP.

Circ Res. 2010 Mar 5;106(4):730-8. doi: 10.1161/CIRCRESAHA.109.206631. Epub 2010 Jan 7.


Mitochondrial UCP2 in the central regulation of metabolism.

Toda C, Diano S.

Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):757-64. doi: 10.1016/j.beem.2014.02.006. Epub 2014 Mar 7. Review.


Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.

Martínez-Zamora A, Meseguer S, Esteve JM, Villarroya M, Aguado C, Enríquez JA, Knecht E, Armengod ME.

PLoS One. 2015 Dec 7;10(12):e0144273. doi: 10.1371/journal.pone.0144273. eCollection 2015.


Measuring mitochondrial uncoupling protein-2 level and activity in insulinoma cells.

Barlow J, Hirschberg V, Brand MD, Affourtit C.

Methods Enzymol. 2013;528:257-67. doi: 10.1016/B978-0-12-405881-1.00015-X.


Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

Liu D, Chan SL, de Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP.

Neuromolecular Med. 2006;8(3):389-414.


Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells.

Barlow J, Hirschberg Jensen V, Affourtit C.

Redox Biol. 2015;4:14-22. doi: 10.1016/j.redox.2014.11.009. Epub 2014 Nov 28.


Uncoupling protein-2 and the potential link between metabolism and longevity.

Andrews ZB.

Curr Aging Sci. 2010 Jul;3(2):102-12. Review.


The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale.

Patel N, Barrientos A, Landgraf R.

J Biol Chem. 2013 Dec 6;288(49):35253-65. doi: 10.1074/jbc.M113.478271. Epub 2013 Oct 18.


Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression.

Chu AC, Ho PW, Kwok KH, Ho JW, Chan KH, Liu HF, Kung MH, Ramsden DB, Ho SL.

Free Radic Biol Med. 2009 Mar 15;46(6):810-20. doi: 10.1016/j.freeradbiomed.2008.12.015. Epub 2008 Dec 25.


Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.

Akhmedov AT, Rybin V, Marín-García J.

Heart Fail Rev. 2015 Mar;20(2):227-49. doi: 10.1007/s10741-014-9457-4. Review.


Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury.

Serviddio G, Bellanti F, Tamborra R, Rollo T, Capitanio N, Romano AD, Sastre J, Vendemiale G, Altomare E.

Gut. 2008 Jul;57(7):957-65. doi: 10.1136/gut.2007.147496. Epub 2008 Feb 28.


Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.

Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K.

Cell Metab. 2016 Apr 12;23(4):663-74. doi: 10.1016/j.cmet.2016.03.001. Epub 2016 Mar 31.


Mitochondrial retrograde signaling mediated by UCP2 inhibits cancer cell proliferation and tumorigenesis.

Esteves P, Pecqueur C, Ransy C, Esnous C, Lenoir V, Bouillaud F, Bulteau AL, Lombès A, Prip-Buus C, Ricquier D, Alves-Guerra MC.

Cancer Res. 2014 Jul 15;74(14):3971-82. doi: 10.1158/0008-5472.CAN-13-3383. Epub 2014 May 22.


Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells.

Ho PW, Liu HF, Ho JW, Zhang WY, Chu AC, Kwok KH, Ge X, Chan KH, Ramsden DB, Ho SL.

Neurotox Res. 2010 May;17(4):332-43. doi: 10.1007/s12640-009-9109-y. Epub 2009 Sep 10.


Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin.

Ayyasamy V, Owens KM, Desouki MM, Liang P, Bakin A, Thangaraj K, Buchsbaum DJ, LoBuglio AF, Singh KK.

PLoS One. 2011;6(9):e24792. doi: 10.1371/journal.pone.0024792. Epub 2011 Sep 15.

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