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Items: 1 to 20 of 67

1.

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.

Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T.

EMBO J. 2012 Jan 18;31(2):481-93. doi: 10.1038/emboj.2011.416. Epub 2011 Nov 15.

2.

MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility.

Hosono Y, Usukura J, Yamaguchi T, Yanagisawa K, Suzuki M, Takahashi T.

Biochem Biophys Res Commun. 2012 Nov 9;428(1):173-8. doi: 10.1016/j.bbrc.2012.10.036. Epub 2012 Oct 12.

PMID:
23068101
3.

Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway.

Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR.

Mol Pharmacol. 2013 Feb;83(2):454-69. doi: 10.1124/mol.112.083097. Epub 2012 Nov 27.

5.

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.

Pinner S, Sahai E.

Nat Cell Biol. 2008 Feb;10(2):127-37. doi: 10.1038/ncb1675. Epub 2008 Jan 20. Erratum in: Nat Cell Biol. 2008 Mar;10(3):370.

PMID:
18204440
6.

Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).

Runkle EA, Rice SJ, Qi J, Masser D, Antonetti DA, Winslow MM, Mu D.

J Biol Chem. 2012 Aug 17;287(34):28790-801. doi: 10.1074/jbc.M112.367987. Epub 2012 Jul 2.

7.

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells.

Murata K, Noda SE, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T.

J Radiat Res. 2014 Jul;55(4):658-64. doi: 10.1093/jrr/rru002. Epub 2014 Mar 21.

8.

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.

Patel RA, Liu Y, Wang B, Li R, Sebti SM.

Oncogene. 2014 Jan 30;33(5):550-5. doi: 10.1038/onc.2012.634. Epub 2013 Feb 11.

9.

Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.

Tanaka H, Yanagisawa K, Shinjo K, Taguchi A, Maeno K, Tomida S, Shimada Y, Osada H, Kosaka T, Matsubara H, Mitsudomi T, Sekido Y, Tanimoto M, Yatabe Y, Takahashi T.

Cancer Res. 2007 Jul 1;67(13):6007-11.

10.

Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly.

Xia D, Stull JT, Kamm KE.

Exp Cell Res. 2005 Apr 1;304(2):506-17. Epub 2004 Dec 30.

PMID:
15748895
11.

Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.

Wong CC, Wong CM, Ko FC, Chan LK, Ching YP, Yam JW, Ng IO.

PLoS One. 2008 Jul 23;3(7):e2779. doi: 10.1371/journal.pone.0002779.

12.

Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.

Das A, Acharya S, Gottipati KR, McKnight JB, Chandru H, Alcorn JL, Boggaram V.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L427-40. doi: 10.1152/ajplung.00090.2011. Epub 2011 Jul 22. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L1003.

13.

RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.

Byrne FL, Yang L, Phillips PA, Hansford LM, Fletcher JI, Ormandy CJ, McCarroll JA, Kavallaris M.

Oncogene. 2014 Feb 13;33(7):882-90. doi: 10.1038/onc.2013.11. Epub 2013 Feb 11.

PMID:
23396365
14.

MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.

Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X, Shi Y.

Clin Cancer Res. 2011 Dec 15;17(24):7574-83. doi: 10.1158/1078-0432.CCR-11-1714. Epub 2011 Oct 12. Erratum in: Clin Cancer Res. 2012 Aug 1;18(15)4216.

15.

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells.

Eitaki M, Yamamori T, Meike S, Yasui H, Inanami O.

BMC Cancer. 2012 Oct 12;12:469. doi: 10.1186/1471-2407-12-469.

16.

Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma.

Shiba-Ishii A, Noguchi M.

Am J Pathol. 2012 Apr;180(4):1653-62. doi: 10.1016/j.ajpath.2011.12.014. Epub 2012 Feb 4.

PMID:
22310466
17.

Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors.

Hopkins AM, Pineda AA, Winfree LM, Brown GT, Laukoetter MG, Nusrat A.

Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G806-17. Epub 2006 Nov 30.

18.

EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility.

Parri M, Buricchi F, Giannoni E, Grimaldi G, Mello T, Raugei G, Ramponi G, Chiarugi P.

J Biol Chem. 2007 Jul 6;282(27):19619-28. Epub 2007 Apr 22.

19.

E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cells.

Hakuma N, Kinoshita I, Shimizu Y, Yamazaki K, Yoshida K, Nishimura M, Dosaka-Akita H.

Cancer Res. 2005 Dec 1;65(23):10776-82.

20.

Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma.

Xia L, Huang W, Tian D, Zhu H, Zhang Y, Hu H, Fan D, Nie Y, Wu K.

J Hepatol. 2012 Sep;57(3):600-12. doi: 10.1016/j.jhep.2012.04.020. Epub 2012 May 18.

PMID:
22613004

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