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Items: 1 to 20 of 115

1.

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.

Ishibashi K, Fujita N, Kanno E, Omori H, Yoshimori T, Itoh T, Fukuda M.

Autophagy. 2011 Dec;7(12):1500-13.

2.

Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.

Kim JH, Hong SB, Lee JK, Han S, Roh KH, Lee KE, Kim YK, Choi EJ, Song HK.

Autophagy. 2015;11(1):75-87. doi: 10.4161/15548627.2014.984276.

3.

WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA.

Mol Cell. 2014 Jul 17;55(2):238-52. doi: 10.1016/j.molcel.2014.05.021. Epub 2014 Jun 19.

4.

Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells.

Chen ZH, Cao JF, Zhou JS, Liu H, Che LQ, Mizumura K, Li W, Choi AM, Shen HH.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1016-25. doi: 10.1152/ajplung.00268.2013. Epub 2014 Apr 11.

5.
6.

Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma.

Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW.

Cell Host Microbe. 2012 Apr 19;11(4):397-409. doi: 10.1016/j.chom.2012.03.002.

7.

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.

Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T.

Mol Biol Cell. 2008 May;19(5):2092-100. doi: 10.1091/mbc.E07-12-1257. Epub 2008 Mar 5.

8.

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation.

Romanov J, Walczak M, Ibiricu I, Schüchner S, Ogris E, Kraft C, Martens S.

EMBO J. 2012 Nov 14;31(22):4304-17. doi: 10.1038/emboj.2012.278. Epub 2012 Oct 12.

9.

The Ubi brothers reunited.

Noda T, Fujita N, Yoshimori T.

Autophagy. 2008 May;4(4):540-1. Epub 2008 Mar 26.

PMID:
18398292
10.

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.

Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J.

Cell. 2010 Aug 20;142(4):590-600. doi: 10.1016/j.cell.2010.07.018.

11.

The N-terminal region of the human autophagy protein ATG16L1 contains a domain that folds into a helical structure consistent with formation of a coiled-coil.

Parkhouse R, Ebong IO, Robinson CV, Monie TP.

PLoS One. 2013 Sep 24;8(9):e76237. doi: 10.1371/journal.pone.0076237. eCollection 2013.

12.

Rab33B and its autophagic Atg5/12/16L1 effector assist in hepatitis B virus naked capsid formation and release.

Döring T, Prange R.

Cell Microbiol. 2015 May;17(5):747-64. doi: 10.1111/cmi.12398. Epub 2015 Jan 24.

PMID:
25439980
13.

Dynamics of Atg5-Atg12-Atg16L1 Aggregation and Deaggregation.

Kharaziha P, Panaretakis T.

Methods Enzymol. 2017;587:247-255. doi: 10.1016/bs.mie.2016.09.059. Epub 2016 Dec 3.

PMID:
28253959
14.

Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation.

Moloughney JG, Monken CE, Tao H, Zhang H, Thomas JD, Lattime EC, Jin S.

Autophagy. 2011 Dec;7(12):1434-47.

15.

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.

Otomo C, Metlagel Z, Takaesu G, Otomo T.

Nat Struct Mol Biol. 2013 Jan;20(1):59-66. doi: 10.1038/nsmb.2431. Epub 2012 Dec 2.

16.

Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation.

Walczak M, Martens S.

Autophagy. 2013 Mar;9(3):424-5. doi: 10.4161/auto.22931. Epub 2013 Jan 15.

17.

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.

Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbé S, Clague MJ, Tooze SA.

Autophagy. 2010 May;6(4):506-22. doi: 10.4161/auto.6.4.11863. Epub 2010 May 16.

PMID:
20505359
18.

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.

Bansal M, Moharir SC, Sailasree SP, Sirohi K, Sudhakar C, Sarathi DP, Lakshmi BJ, Buono M, Kumar S, Swarup G.

J Biol Chem. 2018 Jan 5;293(1):132-147. doi: 10.1074/jbc.M117.801944. Epub 2017 Nov 13.

PMID:
29133525
19.

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.

Sou YS, Waguri S, Iwata J, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M.

Mol Biol Cell. 2008 Nov;19(11):4762-75. doi: 10.1091/mbc.E08-03-0309. Epub 2008 Sep 3.

20.

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP.

Immunity. 2012 Jun 29;36(6):933-46. doi: 10.1016/j.immuni.2012.03.025.

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