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Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.

Salsman J, Jagannathan M, Paladino P, Chan PK, Dellaire G, Raught B, Frappier L.

J Virol. 2012 Jan;86(2):806-20. doi: 10.1128/JVI.05442-11. Epub 2011 Nov 9.


Nuclear body formation and PML body remodeling by the human cytomegalovirus protein UL35.

Salsman J, Wang X, Frappier L.

Virology. 2011 Jun 5;414(2):119-29. doi: 10.1016/j.virol.2011.03.013. Epub 2011 Apr 13.


Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.

Hakata Y, Miyazawa M, Landau NR.

Virol J. 2014 Jun 9;11:108. doi: 10.1186/1743-422X-11-108.


A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, Yu XF.

Cell Microbiol. 2012 Nov;14(11):1745-56. doi: 10.1111/j.1462-5822.2012.01835.x. Epub 2012 Aug 9.


Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization.

Maschkowitz G, Gärtner S, Hofmann-Winkler H, Fickenscher H, Winkler M.

J Virol. 2018 Apr 13;92(9). pii: e00013-18. doi: 10.1128/JVI.00013-18. Print 2018 May 1.


Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.

Gérard FC, Yang R, Romani B, Poisson A, Belzile JP, Rougeau N, Cohen ÉA.

PLoS One. 2014 Feb 18;9(2):e89195. doi: 10.1371/journal.pone.0089195. eCollection 2014.


HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.

Ahn J, Vu T, Novince Z, Guerrero-Santoro J, Rapic-Otrin V, Gronenborn AM.

J Biol Chem. 2010 Nov 26;285(48):37333-41. doi: 10.1074/jbc.M110.133181. Epub 2010 Sep 24.


Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.

Le Rouzic E, Morel M, Ayinde D, Belaïdouni N, Letienne J, Transy C, Margottin-Goguet F.

J Biol Chem. 2008 Aug 1;283(31):21686-92. doi: 10.1074/jbc.M710298200. Epub 2008 Jun 4.


RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions.

Xiaofei E, Stadler BM, Debatis M, Wang S, Lu S, Kowalik TF.

J Virol. 2012 May;86(10):5660-73. doi: 10.1128/JVI.06338-11. Epub 2012 Mar 21.


Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest.

Belzile JP, Abrahamyan LG, Gérard FC, Rougeau N, Cohen EA.

PLoS Pathog. 2010 Sep 2;6(9):e1001080. doi: 10.1371/journal.ppat.1001080.


Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes.

Zhang Y, Feng S, Chen F, Chen H, Wang J, McCall C, Xiong Y, Deng XW.

Plant Cell. 2008 Jun;20(6):1437-55. doi: 10.1105/tpc.108.058891. Epub 2008 Jun 13.


HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.

Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F.

Cell Cycle. 2007 Jan 15;6(2):182-8. Epub 2007 Jan 17.


The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover.

Wen X, Casey Klockow L, Nekorchuk M, Sharifi HJ, de Noronha CM.

PLoS One. 2012;7(1):e30939. doi: 10.1371/journal.pone.0030939. Epub 2012 Jan 24.


Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.

Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11778-83. Epub 2007 Jul 3.


Analysis of the interactions of viral and cellular factors with human cytomegalovirus lytic origin of replication, oriLyt.

Kagele D, Rossetto CC, Tarrant MT, Pari GS.

Virology. 2012 Mar 15;424(2):106-14. doi: 10.1016/j.virol.2011.12.010. Epub 2012 Jan 10.


Human cytomegalovirus riding the cell cycle.

Spector DH.

Med Microbiol Immunol. 2015 Jun;204(3):409-19. doi: 10.1007/s00430-015-0396-z. Epub 2015 Mar 17. Review.


HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner.

Liu X, Guo H, Wang H, Markham R, Wei W, Yu XF.

Biochem Biophys Res Commun. 2015 Apr 3;459(2):214-219. doi: 10.1016/j.bbrc.2015.02.060. Epub 2015 Feb 19.


The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction.

Wu Y, Zhou X, Barnes CO, DeLucia M, Cohen AE, Gronenborn AM, Ahn J, Calero G.

Nat Struct Mol Biol. 2016 Oct;23(10):933-940. doi: 10.1038/nsmb.3284. Epub 2016 Aug 29.


Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.

Maudet C, Bertrand M, Le Rouzic E, Lahouassa H, Ayinde D, Nisole S, Goujon C, Cimarelli A, Margottin-Goguet F, Transy C.

J Biol Chem. 2011 Jul 8;286(27):23742-52. doi: 10.1074/jbc.M111.220780. Epub 2011 May 12.

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