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Human Immunodeficiency Virus nef signature sequences are associated with pulmonary hypertension.

Almodovar S, Knight R, Allshouse AA, Roemer S, Lozupone C, McDonald D, Widmann J, Voelkel NF, Shelton RJ, Suarez EB, Hammer KW, Goujard C, Petrosillo N, Simonneau G, Hsue PY, Humbert M, Flores SC.

AIDS Res Hum Retroviruses. 2012 Jun;28(6):607-18. doi: 10.1089/AID.2011.0021. Epub 2012 Jan 17.


HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.

Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC.

Am J Respir Crit Care Med. 2006 Aug 15;174(4):437-45. Epub 2006 May 25.


SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques.

Mandell CP, Reyes RA, Cho K, Sawai ET, Fang AL, Schmidt KA, Luciw PA.

Virology. 1999 Dec 20;265(2):235-51.


Chronology of genetic changes in the vpu, env, and Nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques.

McCormick-Davis C, Zhao LJ, Mukherjee S, Leung K, Sheffer D, Joag SV, Narayan O, Stephens EB.

Virology. 1998 Sep 1;248(2):275-83.


Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef.

Almodovar S, Hsue PY, Morelli J, Huang L, Flores SC; Lung HIV Study.

Proc Am Thorac Soc. 2011 Jun;8(3):308-12. doi: 10.1513/pats.201006-046WR.


A simian human immunodeficiency virus with a nonfunctional Vpu (deltavpuSHIV(KU-1bMC33)) isolated from a macaque with neuroAIDS has selected for mutations in env and nef that contributed to its pathogenic phenotype.

Singh DK, McCormick C, Pacyniak E, Lawrence K, Dalton SB, Pinson DM, Sun F, Berman NE, Calvert M, Gunderson RS, Wong SW, Stephens EB.

Virology. 2001 Mar 30;282(1):123-40.


From viral infection to pulmonary arterial hypertension: a role for viral proteins?

Voelkel NF, Cool CD, Flores S.

AIDS. 2008 Sep;22 Suppl 3:S49-53. doi: 10.1097/01.aids.0000327516.55041.01. Review.


Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.

Martins MA, Tully DC, Cruz MA, Power KA, Veloso de Santana MG, Bean DJ, Ogilvie CB, Gadgil R, Lima NS, Magnani DM, Ejima K, Allison DB, Piatak M Jr, Altman JD, Parks CL, Rakasz EG, Capuano S 3rd, Galler R, Bonaldo MC, Lifson JD, Allen TM, Watkins DI.

J Virol. 2015 Nov;89(21):10802-20. doi: 10.1128/JVI.01440-15. Epub 2015 Aug 19.


Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques.

Sehgal PB, Mukhopadhyay S, Patel K, Xu F, Almodóvar S, Tuder RM, Flores SC.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L729-37. doi: 10.1152/ajplung.00087.2009. Epub 2009 Jul 31.


Antibody response to the negative regulatory factor (nef) in experimentally infected macaques: correlation with viremia, disease progression, and seroconversion to structural viral proteins.

Kirchhoff F, Voss G, Nick S, Stahl-Hennig C, Coulibaly C, Frank R, Jentsch KD, Hunsmann G.

Virology. 1991 Jul;183(1):267-72.


T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.

Münch J, Janardhan A, Stolte N, Stahl-Hennig C, Ten Haaft P, Heeney JL, Swigut T, Kirchhoff F, Skowronski J.

J Virol. 2002 Dec;76(23):12360-4.


A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques.

McCormick-Davis C, Dalton SB, Hout DR, Singh DK, Berman NE, Yong C, Pinson DM, Foresman L, Stephens EB.

Virology. 2000 Jun 20;272(1):112-26.


Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIV(KU-1bMC33)) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathogenic for pig-tailed macaques.

Hout DR, Gomez ML, Pacyniak E, Mulcahy ER, Gomez LM, Jackson M, Flick M, Fegley B, McCormick C, Wisdom BJ, Culley N, Pinson DM, Powers M, Wong SW, Stephens EB.

Virology. 2004 May 20;323(1):91-107.


Pathogenic simian/human immunodeficiency virus SHIV(KU) inoculated into immunized macaques caused infection, but virus burdens progressively declined with time.

Silverstein PS, Mackay GA, Mukherjee S, Li Z, Piatak M Jr, Lifson JD, Narayan O, Kumar A.

J Virol. 2000 Nov;74(22):10489-97.


Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.

Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG.

J Infect Dis. 2010 Aug 15;202(4):614-23. doi: 10.1086/654817.

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