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Items: 1 to 20 of 90

1.

Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.

Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, Strynadka NC, McMaster WR, Finlay BB, Foster LJ, Young RN, Reiner NE, Cherkasov A.

ACS Chem Biol. 2012 Feb 17;7(2):350-9. doi: 10.1021/cb2003576.

PMID:
22066782
2.

Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.

Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE.

Antimicrob Agents Chemother. 2011 May;55(5):2042-53. doi: 10.1128/AAC.01250-10.

3.

Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE.

J Biol Chem. 2011 Dec 30;286(52):44716-25. doi: 10.1074/jbc.M111.289033.

4.

Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.

Kumar NS, Amandoron EA, Cherkasov A, Finlay BB, Gong H, Jackson L, Kaur S, Lian T, Moreau A, Labrière C, Reiner NE, See RH, Strynadka NC, Thorson L, Wong EW, Worrall L, Zoraghi R, Young RN.

Bioorg Med Chem. 2012 Dec 15;20(24):7069-82. doi: 10.1016/j.bmc.2012.10.002.

PMID:
23141418
5.

Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase.

Chan BC, Ip M, Lau CB, Lui SL, Jolivalt C, Ganem-Elbaz C, Litaudon M, Reiner NE, Gong H, See RH, Fung KP, Leung PC.

J Ethnopharmacol. 2011 Sep 1;137(1):767-73. doi: 10.1016/j.jep.2011.06.039.

PMID:
21782012
6.

Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.

Zoraghi R, Campbell S, Kim C, Dullaghan EM, Blair LM, Gillard RM, Reiner NE, Sperry J.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5059-62. doi: 10.1016/j.bmcl.2014.09.010.

PMID:
25266785
7.

Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from methicillin-resistant Staphylococcus aureus.

Zoraghi R, See RH, Gong H, Lian T, Swayze R, Finlay BB, Brunham RC, McMaster WR, Reiner NE.

Biochemistry. 2010 Sep 7;49(35):7733-47. doi: 10.1021/bi100780t.

PMID:
20707314
8.

High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.

Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Cheng WC, Wong CH.

Bioorg Med Chem. 2010 Dec 15;18(24):8512-29. doi: 10.1016/j.bmc.2010.10.036.

PMID:
21075637
9.

Synthetic analogues of the marine bisindole deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase.

Veale CG, Zoraghi R, Young RM, Morrison JP, Pretheeban M, Lobb KA, Reiner NE, Andersen RJ, Davies-Coleman MT.

J Nat Prod. 2015 Mar 27;78(3):355-62. doi: 10.1021/np500755v.

PMID:
25372480
10.

Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.

Kumar NS, Dullaghan EM, Finlay BB, Gong H, Reiner NE, Jon Paul Selvam J, Thorson LM, Campbell S, Vitko N, Richardson AR, Zoraghi R, Young RN.

Bioorg Med Chem. 2014 Mar 1;22(5):1708-25. doi: 10.1016/j.bmc.2014.01.020.

PMID:
24508307
11.

Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase.

Chan BC, Ip M, Gong H, Lui SL, See RH, Jolivalt C, Fung KP, Leung PC, Reiner NE, Lau CB.

Phytomedicine. 2013 May 15;20(7):611-4. doi: 10.1016/j.phymed.2013.02.007.

PMID:
23541215
12.

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

Lu H, Tonge PJ.

Acc Chem Res. 2008 Jan;41(1):11-20. doi: 10.1021/ar700156e. Review.

PMID:
18193820
13.

Identification and characterization of potential drug targets by subtractive genome analyses of methicillin resistant Staphylococcus aureus.

Uddin R, Saeed K.

Comput Biol Chem. 2014 Feb;48:55-63. doi: 10.1016/j.compbiolchem.2013.11.005.

PMID:
24361957
14.

Discovery of novel selective inhibitors of Staphylococcus aureus β-ketoacyl acyl carrier protein synthase III.

Lee JY, Jeong KW, Shin S, Lee JU, Kim Y.

Eur J Med Chem. 2012 Jan;47(1):261-9. doi: 10.1016/j.ejmech.2011.10.052.

PMID:
22104972
15.

Multistep virtual screening for rapid and efficient identification of non-nucleoside bacterial thymidine kinase inhibitors.

Zander J, Hartenfeller M, Hähnke V, Proschak E, Besier S, Wichelhaus TA, Schneider G.

Chemistry. 2010 Aug 16;16(31):9630-7. doi: 10.1002/chem.201001347.

PMID:
20648496
16.

Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.

Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T, Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE.

J Proteome Res. 2011 Mar 4;10(3):1139-50. doi: 10.1021/pr100918u.

PMID:
21166474
17.

Ab initio design of potent anti-MRSA peptides based on database filtering technology.

Mishra B, Wang G.

J Am Chem Soc. 2012 Aug 1;134(30):12426-9. doi: 10.1021/ja305644e.

18.

Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus.

Ding R, Wu XC, Qian CD, Teng Y, Li O, Zhan ZJ, Zhao YH.

J Microbiol. 2011 Dec;49(6):942-9. doi: 10.1007/s12275-011-1153-7.

PMID:
22203557
19.

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).

Miller WH, Seefeld MA, Newlander KA, Uzinskas IN, Burgess WJ, Heerding DA, Yuan CC, Head MS, Payne DJ, Rittenhouse SF, Moore TD, Pearson SC, Berry V, DeWolf WE Jr, Keller PM, Polizzi BJ, Qiu X, Janson CA, Huffman WF.

J Med Chem. 2002 Jul 18;45(15):3246-56.

PMID:
12109908
20.

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors.

Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA.

J Antibiot (Tokyo). 2015 Jun;68(6):361-7. doi: 10.1038/ja.2014.163.

PMID:
25464974
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