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Items: 1 to 20 of 173


Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.

Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q.

J Biol Chem. 2012 Jan 6;287(2):1054-65. doi: 10.1074/jbc.M111.264481. Epub 2011 Nov 7.


An interconnected hierarchical model of cell death regulation by the BCL-2 family.

Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH.

Nat Cell Biol. 2015 Oct;17(10):1270-81. doi: 10.1038/ncb3236. Epub 2015 Sep 7.


AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts.

González-Gironès DM, Moncunill-Massaguer C, Iglesias-Serret D, Cosialls AM, Pérez-Perarnau A, Palmeri CM, Rubio-Patiño C, Villunger A, Pons G, Gil J.

Apoptosis. 2013 Aug;18(8):1008-16. doi: 10.1007/s10495-013-0850-6.


Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

McKenzie MD, Jamieson E, Jansen ES, Scott CL, Huang DC, Bouillet P, Allison J, Kay TW, Strasser A, Thomas HE.

Diabetes. 2010 Mar;59(3):644-52. doi: 10.2337/db09-1151. Epub 2009 Dec 3.


The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.


BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.

Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Science. 2010 Dec 3;330(6009):1390-3. doi: 10.1126/science.1190217.


Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis.

Zhang L, Xing D, Chen M.

Apoptosis. 2008 Jul;13(7):950-8. doi: 10.1007/s10495-008-0226-5. Epub 2008 May 24.


Bax deficiency promotes an up-regulation of Bim(EL) and Bak during striatal and cortical postnatal development, and after excitotoxic injury.

Gavaldà N, Pérez-Navarro E, García-Martínez JM, Marco S, Benito A, Alberch J.

Mol Cell Neurosci. 2008 Apr;37(4):663-72. doi: 10.1016/j.mcn.2007.12.013. Epub 2007 Dec 15.


BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast.

Juhásová B, Mentel M, Bhatia-Kiššová I, Zeman I, Kolarov J, Forte M, Polčic P.

FEBS Lett. 2011 Sep 2;585(17):2709-13. doi: 10.1016/j.febslet.2011.07.027. Epub 2011 Jul 31.


Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.

Shamas-Din A, Bindner S, Chi X, Leber B, Andrews DW, Fradin C.

Biochem J. 2015 May 1;467(3):495-505. doi: 10.1042/BJ20141291.


Genetically defining the mechanism of Puma- and Bim-induced apoptosis.

Garrison SP, Phillips DC, Jeffers JR, Chipuk JE, Parsons MJ, Rehg JE, Opferman JT, Green DR, Zambetti GP.

Cell Death Differ. 2012 Apr;19(4):642-9. doi: 10.1038/cdd.2011.136. Epub 2011 Oct 21.


BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.

Weber A, Paschen SA, Heger K, Wilfling F, Frankenberg T, Bauerschmitt H, Seiffert BM, Kirschnek S, Wagner H, Häcker G.

J Cell Biol. 2007 May 21;177(4):625-36.


Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim.

Ni B, Ma Q, Li B, Zhao L, Liu Y, Zhu Y, Chen Q.

Clin Cancer Res. 2012 Jan 1;18(1):140-51. doi: 10.1158/1078-0432.CCR-10-3450. Epub 2011 Nov 2.


Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.

Ferrer PE, Frederick P, Gulbis JM, Dewson G, Kluck RM.

PLoS One. 2012;7(3):e31510. doi: 10.1371/journal.pone.0031510. Epub 2012 Mar 19.


Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.

Lim DY, Park JH.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1060-8. doi: 10.1152/ajpgi.90490.2008. Epub 2009 Mar 5.


Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release.

Sheridan C, Delivani P, Cullen SP, Martin SJ.

Mol Cell. 2008 Aug 22;31(4):570-85. doi: 10.1016/j.molcel.2008.08.002.


BH3 domains other than Bim and Bid can directly activate Bax/Bak.

Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.

J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1.

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