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Items: 1 to 20 of 121

1.

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5.

Granchi C, Roy S, Mottinelli M, Nardini E, Campinoti F, Tuccinardi T, Lanza M, Betti L, Giannaccini G, Lucacchini A, Martinelli A, Macchia M, Minutolo F.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7331-6. doi: 10.1016/j.bmcl.2011.10.031. Epub 2011 Oct 17.

PMID:
22056743
2.

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.

Granchi C, Roy S, De Simone A, Salvetti I, Tuccinardi T, Martinelli A, Macchia M, Lanza M, Betti L, Giannaccini G, Lucacchini A, Giovannetti E, Sciarrillo R, Peters GJ, Minutolo F.

Eur J Med Chem. 2011 Nov;46(11):5398-407. doi: 10.1016/j.ejmech.2011.08.046. Epub 2011 Sep 8.

PMID:
21944286
3.

Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.

Manerba M, Vettraino M, Fiume L, Di Stefano G, Sartini A, Giacomini E, Buonfiglio R, Roberti M, Recanatini M.

ChemMedChem. 2012 Feb 6;7(2):311-7. doi: 10.1002/cmdc.201100471. Epub 2011 Nov 4.

PMID:
22052811
4.

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F.

J Med Chem. 2011 Mar 24;54(6):1599-612. doi: 10.1021/jm101007q. Epub 2011 Feb 18.

PMID:
21332213
5.

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.

Granchi C, Calvaresi EC, Tuccinardi T, Paterni I, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F.

Org Biomol Chem. 2013 Oct 14;11(38):6588-96. doi: 10.1039/c3ob40870a. Epub 2013 Aug 29.

6.

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Güzel O, Temperini C, Innocenti A, Scozzafava A, Salman A, Supuran CT.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):152-8. Epub 2007 Nov 4.

PMID:
18024029
7.
8.

[Non-linear, non-competitive inhibition of lactate dehydrogenase with carboxylic acid anions (substrate analogues)].

Saburova EA, Gol'dshteĭn BN, Elfimova LI, Vol'kenshteĭn MV.

Mol Biol (Mosk). 1982 Nov-Dec;16(6):1173-82. Russian.

PMID:
7155138
9.
10.

Small-molecule inhibitors of human LDH5.

Granchi C, Paterni I, Rani R, Minutolo F.

Future Med Chem. 2013 Oct;5(16):1967-91. doi: 10.4155/fmc.13.151. Review.

11.

Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum.

Gomez MS, Piper RC, Hunsaker LA, Royer RE, Deck LM, Makler MT, Vander Jagt DL.

Mol Biochem Parasitol. 1997 Dec 1;90(1):235-46.

PMID:
9497046
12.

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4.

Yu Y, Deck JA, Hunsaker LA, Deck LM, Royer RE, Goldberg E, Vander Jagt DL.

Biochem Pharmacol. 2001 Jul 1;62(1):81-9.

PMID:
11377399
13.

Kinetic and crystallographic studies on the active site Arg289Lys mutant of flavocytochrome b2 (yeast L-lactate dehydrogenase).

Mowat CG, Beaudoin I, Durley RC, Barton JD, Pike AD, Chen ZW, Reid GA, Chapman SK, Mathews FS, Lederer F.

Biochemistry. 2000 Mar 28;39(12):3266-75.

PMID:
10727218
14.

1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds as dual inhibitors of human cytosolic phospholipase A2α and fatty acid amide hydrolase.

Zahov S, Drews A, Hess M, Schulze Elfringhoff A, Lehr M.

ChemMedChem. 2011 Mar 7;6(3):544-9. doi: 10.1002/cmdc.201000473. Epub 2011 Jan 21.

PMID:
21259444
15.

Cyclohex-1-ene carboxylic acids: synthesis and biological evaluation of novel inhibitors of human 5 alpha reductase.

Baston E, Salem OI, Hartmann RW.

Arch Pharm (Weinheim). 2003 Mar;336(1):31-8.

PMID:
12666251
16.

Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.

Showalter HD, Sercel AD, Leja BM, Wolfangel CD, Ambroso LA, Elliott WL, Fry DW, Kraker AJ, Howard CT, Lu GH, Moore CW, Nelson JM, Roberts BJ, Vincent PW, Denny WA, Thompson AM.

J Med Chem. 1997 Feb 14;40(4):413-26.

PMID:
9046331
18.

Synthesis and SAR of highly selective MMP-13 inhibitors.

Li J, Rush TS 3rd, Li W, DeVincentis D, Du X, Hu Y, Thomason JR, Xiang JS, Skotnicki JS, Tam S, Cunningham KM, Chockalingam PS, Morris EA, Levin JI.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6.

PMID:
16153831
19.

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.

Xiang Y, Hirth B, Asmussen G, Biemann HP, Bishop KA, Good A, Fitzgerald M, Gladysheva T, Jain A, Jancsics K, Liu J, Metz M, Papoulis A, Skerlj R, Stepp JD, Wei RR.

Bioorg Med Chem Lett. 2011 May 15;21(10):3050-6. doi: 10.1016/j.bmcl.2011.03.030. Epub 2011 Mar 16.

PMID:
21507633
20.

(1-Benzylindole-3-yl)alkanoic acids; novel nonsteroidal inhibitors of steroid 5 alpha-reductase (I).

Sawada K, Hirai H, Golden P, Okada S, Sawada Y, Hashimoto M, Tanaka H.

Chem Pharm Bull (Tokyo). 1998 Nov;46(11):1683-7.

PMID:
9890779

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