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Items: 1 to 20 of 107

1.

Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.

Koh CY, Kumar S, Kazimirova M, Nuttall PA, Radhakrishnan UP, Kim S, Jagadeeswaran P, Imamura T, Mizuguchi J, Iwanaga S, Swaminathan K, Kini RM.

PLoS One. 2011;6(10):e26367. doi: 10.1371/journal.pone.0026367. Epub 2011 Oct 28.

2.

Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick.

Koh CY, Kazimirova M, Trimnell A, Takac P, Labuda M, Nuttall PA, Kini RM.

J Biol Chem. 2007 Oct 5;282(40):29101-13. Epub 2007 Aug 7.

3.
4.

Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.

Figueiredo AC, de Sanctis D, Gutiérrez-Gallego R, Cereija TB, Macedo-Ribeiro S, Fuentes-Prior P, Pereira PJ.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3649-58. doi: 10.1073/pnas.1211614109. Epub 2012 Dec 5.

5.

Anophelin: kinetics and mechanism of thrombin inhibition.

Francischetti IM, Valenzuela JG, Ribeiro JM.

Biochemistry. 1999 Dec 14;38(50):16678-85.

PMID:
10600131
6.

Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.

Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.

Biochemistry. 1998 Oct 13;37(41):14420-7.

PMID:
9772168
7.

Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.

Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.

J Mol Biol. 1996 May 24;258(5):851-9. Erratum in: J Mol Biol 1996 Oct 18;263(1):99.

PMID:
8637015
8.

Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.

Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC.

Protein Sci. 1996 Mar;5(3):422-33.

9.

From natural to synthetic multisite thrombin inhibitors.

Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V.

Biopolymers. 1999;51(1):19-39.

PMID:
10380350
10.

Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.

Tabernero L, Chang CY, Ohringer SL, Lau WF, Iwanowicz EJ, Han WC, Wang TC, Seiler SM, Roberts DG, Sack JS.

J Mol Biol. 1995 Feb 10;246(1):14-20.

PMID:
7853394
11.

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.

Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM.

FASEB J. 2017 Jul;31(7):2981-2995. doi: 10.1096/fj.201601216R. Epub 2017 Mar 31.

PMID:
28363953
12.

The tick-derived anticoagulant madanin is processed by thrombin and factor Xa.

Figueiredo AC, de Sanctis D, Pereira PJ.

PLoS One. 2013 Aug 12;8(8):e71866. doi: 10.1371/journal.pone.0071866. eCollection 2013.

13.

Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.

De Filippis V, Colombo G, Russo I, Spadari B, Fontana A.

Biochemistry. 2002 Nov 19;41(46):13556-69.

PMID:
12427016
14.
15.

G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants.

Zavyalova E, Ustinov N, Golovin A, Pavlova G, Kopylov A.

Curr Med Chem. 2016;23(21):2230-44. Review.

PMID:
27183984
16.

Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.

Krishnan R, Mochalkin I, Arni R, Tulinsky A.

Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):294-303.

PMID:
10713516
17.

Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.

Corral-Rodríguez MÁ, Bock PE, Hernández-Carvajal E, Gutiérrez-Gallego R, Fuentes-Prior P.

Blood. 2011 Jun 30;117(26):7164-73. doi: 10.1182/blood-2010-10-315309. Epub 2011 May 9.

19.

Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.

Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.

Protein Sci. 1996 Jun;5(6):1174-83.

20.

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