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Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions.

Chang SC, Mulloy B, Magee AI, Couchman JR.

J Biol Chem. 2011 Dec 30;286(52):44391-402. doi: 10.1074/jbc.M111.285361. Epub 2011 Nov 2.


An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions.

Ohlig S, Pickhinke U, Sirko S, Bandari S, Hoffmann D, Dreier R, Farshi P, Götz M, Grobe K.

J Biol Chem. 2012 Dec 21;287(52):43708-19. doi: 10.1074/jbc.M112.356667. Epub 2012 Nov 1. Erratum in: J Biol Chem. 2013 Feb 15;288(7):5049.


Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog.

Farshi P, Ohlig S, Pickhinke U, Höing S, Jochmann K, Lawrence R, Dreier R, Dierker T, Grobe K.

J Biol Chem. 2011 Jul 1;286(26):23608-19. doi: 10.1074/jbc.M110.206474. Epub 2011 May 13.


Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries.

Billings PC, Pacifici M.

Connect Tissue Res. 2015;56(4):272-80. doi: 10.3109/03008207.2015.1045066. Review.


Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans.

Ortmann C, Pickhinke U, Exner S, Ohlig S, Lawrence R, Jboor H, Dreier R, Grobe K.

J Cell Sci. 2015 Jun 15;128(12):2374-85. doi: 10.1242/jcs.170670. Epub 2015 May 12. Erratum in: J Cell Sci. 2015 Dec 1;128(23):4462.


Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma.

Damhofer H, Medema JP, Veenstra VL, Badea L, Popescu I, Roelink H, Bijlsma MF.

Mol Oncol. 2013 Dec;7(6):1031-42. doi: 10.1016/j.molonc.2013.08.004. Epub 2013 Aug 16.


Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation.

Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA.

J Biol Chem. 2013 Sep 6;288(36):26275-88. doi: 10.1074/jbc.M112.438937. Epub 2013 Jul 18.


Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.

Zhang F, McLellan JS, Ayala AM, Leahy DJ, Linhardt RJ.

Biochemistry. 2007 Apr 3;46(13):3933-41. Epub 2007 Mar 10.


Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer.

Nakashima H, Nakamura M, Yamaguchi H, Yamanaka N, Akiyoshi T, Koga K, Yamaguchi K, Tsuneyoshi M, Tanaka M, Katano M.

Cancer Res. 2006 Jul 15;66(14):7041-9.


Heparan sulfate proteoglycans exert positive and negative effects in Shh activity.

Carrasco H, Olivares GH, Faunes F, Oliva C, Larraín J.

J Cell Biochem. 2005 Nov 1;96(4):831-8.


Functional characterization of sonic hedgehog mutations associated with holoprosencephaly.

Traiffort E, Dubourg C, Faure H, Rognan D, Odent S, Durou MR, David V, Ruat M.

J Biol Chem. 2004 Oct 8;279(41):42889-97. Epub 2004 Jul 28.


Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

Konitsiotis AD, Chang SC, Jovanović B, Ciepla P, Masumoto N, Palmer CP, Tate EW, Couchman JR, Magee AI.

PLoS One. 2014 Mar 7;9(3):e89899. doi: 10.1371/journal.pone.0089899. eCollection 2014.


Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.

Steg A, Amm HM, Novak Z, Frost AR, Johnson MR.

Cancer Biol Ther. 2010 Nov 1;10(9):893-902. doi: 10.4161/cbt.10.9.13252. Epub 2010 Nov 1.


Lipoprotein-heparan sulfate interactions in the Hh pathway.

Eugster C, Panáková D, Mahmoud A, Eaton S.

Dev Cell. 2007 Jul;13(1):57-71.


Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.

Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL.

J Cell Biol. 2015 Jun 8;209(5):739-57. doi: 10.1083/jcb.201411024.


Role of heparan sulfate proteoglycans in cell-cell signaling in Drosophila.

Lin X, Perrimon N.

Matrix Biol. 2000 Aug;19(4):303-7. Review.


Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion.

Reiland J, Sanderson RD, Waguespack M, Barker SA, Long R, Carson DD, Marchetti D.

J Biol Chem. 2004 Feb 27;279(9):8047-55. Epub 2003 Nov 20.


Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.

Hirose Y, Itoh T, Miyajima A.

Exp Cell Res. 2009 Sep 10;315(15):2648-57. doi: 10.1016/j.yexcr.2009.06.018. Epub 2009 Jun 24.


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