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Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice.

Zhou H, Huang C, Tong J, Xia XG.

Int J Biol Sci. 2011;7(8):1180-7. Epub 2011 Oct 26.


Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.

Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E.

Acta Neuropathol. 2014 Apr;127(4):477-94. doi: 10.1007/s00401-014-1255-5. Epub 2014 Feb 8.


Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.

Kachroo A, Schwarzschild MA.

Brain Res. 2014 May 14;1563:103-9. doi: 10.1016/j.brainres.2014.03.031. Epub 2014 Mar 26.


Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.

Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z, Xia XG.

Int J Biol Sci. 2007 Mar 5;3(4):242-50.


Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.

McCormack AL, Thiruchelvam M, Manning-Bog AB, Thiffault C, Langston JW, Cory-Slechta DA, Di Monte DA.

Neurobiol Dis. 2002 Jul;10(2):119-27.


5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell.

Kong M, Ba M, Liang H, Ma L, Yu Q, Yu T, Wang Y.

Neurosci Lett. 2012 Aug 22;524(1):35-9. doi: 10.1016/j.neulet.2012.07.001. Epub 2012 Jul 11.


Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice.

Ren JP, Zhao YW, Sun XJ.

Chin Med J (Engl). 2009 Oct 5;122(19):2366-71.


Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.

Wang D, Qian L, Xiong H, Liu J, Neckameyer WS, Oldham S, Xia K, Wang J, Bodmer R, Zhang Z.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13520-5. Epub 2006 Aug 24.


Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice.

Li X, Yin J, Cheng CM, Sun JL, Li Z, Wu YL.

Chin Med J (Engl). 2005 Aug 20;118(16):1357-61.


Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.

Thiruchelvam M, McCormack A, Richfield EK, Baggs RB, Tank AW, Di Monte DA, Cory-Slechta DA.

Eur J Neurosci. 2003 Aug;18(3):589-600.


Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, B├╝eler H.

PLoS One. 2011 Jan 13;6(1):e16038. doi: 10.1371/journal.pone.0016038.


Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.

Liang LP, Kavanagh TJ, Patel M.

Toxicol Sci. 2013 Aug;134(2):366-73. doi: 10.1093/toxsci/kft112. Epub 2013 May 23.


Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: similarity with paraquat neurotoxicity.

Kumar A, Singh BK, Ahmad I, Shukla S, Patel DK, Srivastava G, Kumar V, Pandey HP, Singh C.

Brain Res. 2012 Feb 15;1438:48-64. doi: 10.1016/j.brainres.2011.12.028. Epub 2011 Dec 20.


Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson's Disease from Mitochondrial Dysfunction and Cell Death.

van der Merwe C, van Dyk HC, Engelbrecht L, van der Westhuizen FH, Kinnear C, Loos B, Bardien S.

Mol Neurobiol. 2017 May;54(4):2752-2762. doi: 10.1007/s12035-016-9843-0. Epub 2016 Mar 22.


Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.

Moisoi N, Fedele V, Edwards J, Martins LM.

Neuropharmacology. 2014 Feb;77:350-7. doi: 10.1016/j.neuropharm.2013.10.009. Epub 2013 Oct 23.


Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.

Richter F, Gabby L, McDowell KA, Mulligan CK, De La Rosa K, Sioshansi PC, Mortazavi F, Cely I, Ackerson LC, Tsan L, Murphy NP, Maidment NT, Chesselet MF.

Neurobiol Aging. 2017 Mar;51:54-66. doi: 10.1016/j.neurobiolaging.2016.11.015. Epub 2016 Dec 1.


Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.

Zhou ZD, Refai FS, Xie SP, Ng SH, Chan CH, Ho PG, Zhang XD, Lim TM, Tan EK.

Free Radic Biol Med. 2014 Mar;68:220-33. doi: 10.1016/j.freeradbiomed.2013.12.015. Epub 2013 Dec 25.


Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.

Peng J, Peng L, Stevenson FF, Doctrow SR, Andersen JK.

J Neurosci. 2007 Jun 27;27(26):6914-22.


Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice.

Minnema DJ, Travis KZ, Breckenridge CB, Sturgess NC, Butt M, Wolf JC, Zadory D, Beck MJ, Mathews JM, Tisdel MO, Cook AR, Botham PA, Smith LL.

Regul Toxicol Pharmacol. 2014 Mar;68(2):250-8. doi: 10.1016/j.yrtph.2013.12.010. Epub 2014 Jan 3.

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