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Items: 1 to 20 of 120

1.

Comprehensive analysis of kinase inhibitor selectivity.

Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP.

Nat Biotechnol. 2011 Oct 30;29(11):1046-51. doi: 10.1038/nbt.1990.

PMID:
22037378
2.

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR.

Nat Biotechnol. 2011 Oct 30;29(11):1039-45. doi: 10.1038/nbt.2017.

3.

Large-scale proteomics analysis of the human kinome.

Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H.

Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15.

4.
5.

Recent advances in designing substrate-competitive protein kinase inhibitors.

Han KC, Kim SY, Yang EG.

Curr Pharm Des. 2012;18(20):2875-82. Review.

PMID:
22571656
6.

Quantitative proteomics of kinase inhibitor targets and mechanisms.

Daub H.

ACS Chem Biol. 2015 Jan 16;10(1):201-12. doi: 10.1021/cb5008794. Epub 2014 Dec 17. Review.

PMID:
25474541
7.

Current compound coverage of the kinome.

Hu Y, Furtmann N, Bajorath J.

J Med Chem. 2015 Jan 8;58(1):30-40. doi: 10.1021/jm5008159. Epub 2014 Jul 30.

PMID:
25051177
8.

Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design?

Christmann-Franck S, van Westen GJ, Papadatos G, Beltran Escudie F, Roberts A, Overington JP, Domine D.

J Chem Inf Model. 2016 Sep 26;56(9):1654-75. doi: 10.1021/acs.jcim.6b00122. Epub 2016 Aug 11.

9.

Cross-reactivity virtual profiling of the human kinome by X-react(KIN): a chemical systems biology approach.

Brylinski M, Skolnick J.

Mol Pharm. 2010 Dec 6;7(6):2324-33. doi: 10.1021/mp1002976. Epub 2010 Nov 8.

11.

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.

Kwarcinski FE, Brandvold KR, Phadke S, Beleh OM, Johnson TK, Meagher JL, Seeliger MA, Stuckey JA, Soellner MB.

ACS Chem Biol. 2016 May 20;11(5):1296-304. doi: 10.1021/acschembio.5b01018. Epub 2016 Mar 1.

PMID:
26895387
12.

Extending kinome coverage by analysis of kinase inhibitor broad profiling data.

Jacoby E, Tresadern G, Bembenek S, Wroblowski B, Buyck C, Neefs JM, Rassokhin D, Poncelet A, Hunt J, van Vlijmen H.

Drug Discov Today. 2015 Jun;20(6):652-8. doi: 10.1016/j.drudis.2015.01.002. Epub 2015 Jan 14. Review.

PMID:
25596550
13.

The human kinome and kinase inhibition.

Duong-Ly KC, Peterson JR.

Curr Protoc Pharmacol. 2013 Mar;Chapter 2:Unit2.9. doi: 10.1002/0471141755.ph0209s60.

14.

Prediction of specificity-determining residues for small-molecule kinase inhibitors.

Caffrey DR, Lunney EA, Moshinsky DJ.

BMC Bioinformatics. 2008 Nov 25;9:491. doi: 10.1186/1471-2105-9-491.

15.

Characterisation of kinase-selective inhibitors by chemical proteomics.

Daub H.

Biochim Biophys Acta. 2005 Dec 30;1754(1-2):183-90. Epub 2005 Sep 12. Review.

PMID:
16198161
16.

Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases.

Cox KJ, Shomin CD, Ghosh I.

Future Med Chem. 2011 Jan;3(1):29-43. doi: 10.4155/fmc.10.272. Review.

PMID:
21428824
17.

Interrogating the kinome.

Zhang C, Habets G, Bollag G.

Nat Biotechnol. 2011 Nov 8;29(11):981-3. doi: 10.1038/nbt.2021. No abstract available.

PMID:
22068532
18.

Doing more than just the structure-structural genomics in kinase drug discovery.

Marsden BD, Knapp S.

Curr Opin Chem Biol. 2008 Feb;12(1):40-5. doi: 10.1016/j.cbpa.2008.01.042. Epub 2008 Feb 29. Review.

PMID:
18267130
19.

Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2.

Gyenis L, Turowec JP, Bretner M, Litchfield DW.

Biochim Biophys Acta. 2013 Jul;1834(7):1352-8. doi: 10.1016/j.bbapap.2013.02.006. Epub 2013 Feb 14. Review.

PMID:
23416530
20.

Unexpected off-targets and paradoxical pathway activation by kinase inhibitors.

Hantschel O.

ACS Chem Biol. 2015 Jan 16;10(1):234-45. doi: 10.1021/cb500886n. Epub 2015 Jan 2. Review.

PMID:
25531586

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