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p53, a novel regulator of lipid metabolism pathways.

Goldstein I, Ezra O, Rivlin N, Molchadsky A, Madar S, Goldfinger N, Rotter V.

J Hepatol. 2012 Mar;56(3):656-62. doi: 10.1016/j.jhep.2011.08.022. Epub 2011 Oct 26.


Transcriptome profiling identifies p53 as a key player during calreticulin deficiency: Implications in lipid accumulation.

Vig S, Talwar P, Kaur K, Srivastava R, Srivastava AK, Datta M.

Cell Cycle. 2015;14(14):2274-84. doi: 10.1080/15384101.2015.1046654. Epub 2015 May 6.


Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.

Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V.

Carcinogenesis. 2013 Jan;34(1):190-8. doi: 10.1093/carcin/bgs318. Epub 2012 Oct 10.


Liver-specific phospholipid transfer protein deficiency reduces high-density lipoprotein and non-high-density lipoprotein production in mice.

Yazdanyar A, Quan W, Jin W, Jiang XC.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2058-64. doi: 10.1161/ATVBAHA.113.301628. Epub 2013 Jul 11.


MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway.

Wu H, Ng R, Chen X, Steer CJ, Song G.

Gut. 2016 Nov;65(11):1850-1860. doi: 10.1136/gutjnl-2014-308430. Epub 2015 Aug 17.


Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.

Prokesch A, Graef FA, Madl T, Kahlhofer J, Heidenreich S, Schumann A, Moyschewitz E, Pristoynik P, Blaschitz A, Knauer M, Muenzner M, Bogner-Strauss JG, Dohr G, Schulz TJ, Schupp M.

FASEB J. 2017 Feb;31(2):732-742. doi: 10.1096/fj.201600845R. Epub 2016 Nov 3.


Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.

Siggins S, Bykov I, Hermansson M, Somerharju P, Lindros K, Miettinen TA, Jauhiainen M, Olkkonen VM, Ehnholm C.

Atherosclerosis. 2007 Jan;190(1):114-23. Epub 2006 Mar 22.


Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.

Norata GD, Ongari M, Uboldi P, Pellegatta F, Catapano AL.

Int J Mol Med. 2005 Oct;16(4):717-22.


The WWOX gene modulates high-density lipoprotein and lipid metabolism.

Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, Pajukanta P, Aldaz CM, Genest J.

Circ Cardiovasc Genet. 2014 Aug;7(4):491-504. doi: 10.1161/CIRCGENETICS.113.000248. Epub 2014 May 28.


Regulation of lipid metabolism by p53 - fighting two villains with one sword.

Goldstein I, Rotter V.

Trends Endocrinol Metab. 2012 Nov;23(11):567-75. doi: 10.1016/j.tem.2012.06.007. Epub 2012 Jul 20. Review.


Transcriptional regulation of the tumor suppressor FHL2 by p53 in human kidney and liver cells.

Xu J, Zhou J, Li MS, Ng CF, Ng YK, Lai PB, Tsui SK.

PLoS One. 2014 Aug 14;9(8):e99359. doi: 10.1371/journal.pone.0099359. eCollection 2014.


Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation.

Charni M, Molchadsky A, Goldstein I, Solomon H, Tal P, Goldfinger N, Yang P, Porat Z, Lozano G, Rotter V.

Cell Death Differ. 2016 Mar;23(3):509-20. doi: 10.1038/cdd.2015.119. Epub 2015 Sep 11.


Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

Béaslas O, Metso J, Nissilä E, Laurila PP, Kaiharju E, Batchu KC, Kaipiainen L, Mäyränpää MI, Yan D, Gylling H, Jauhiainen M, Olkkonen VM.

PLoS One. 2013;8(3):e58856. doi: 10.1371/journal.pone.0058856. Epub 2013 Mar 15.


Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload.

Arciello M, Longo A, Viscomi C, Capo C, Angeloni A, Rossi L, Balsano C.

Biometals. 2015 Dec;28(6):1017-29. doi: 10.1007/s10534-015-9886-0. Epub 2015 Oct 5.


Requirement for MLL3 in p53 regulation of hepatic expression of small heterodimer partner and bile acid homeostasis.

Kim DH, Kim J, Lee JW.

Mol Endocrinol. 2011 Dec;25(12):2076-83. doi: 10.1210/me.2011-1198. Epub 2011 Oct 27.


Sphingolipid synthetic pathways are major regulators of lipid homeostasis.

Worgall TS.

Adv Exp Med Biol. 2011;721:139-48. doi: 10.1007/978-1-4614-0650-1_9. Review.


Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells.

Oram JF, Wolfbauer G, Vaughan AM, Tang C, Albers JJ.

J Biol Chem. 2003 Dec 26;278(52):52379-85. Epub 2003 Oct 14.


Cholesterol metabolism, transport, and hepatic regulation in dairy cows during transition and early lactation.

Kessler EC, Gross JJ, Bruckmaier RM, Albrecht C.

J Dairy Sci. 2014 Sep;97(9):5481-90. doi: 10.3168/jds.2014-7926. Epub 2014 Jun 18.


Regulation of the human lipoprotein lipase gene by the forkhead box transcription factor FOXA2/HNF-3β in hepatic cells.

Kanaki M, Kardassis D.

Biochim Biophys Acta. 2017 Mar;1860(3):327-336. doi: 10.1016/j.bbagrm.2017.01.007. Epub 2017 Jan 23.


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