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Items: 1 to 20 of 132

1.

Domain coupling in GPCRs: the engine for induced conformational changes.

Unal H, Karnik SS.

Trends Pharmacol Sci. 2012 Feb;33(2):79-88. doi: 10.1016/j.tips.2011.09.007. Epub 2011 Oct 29. Review.

2.

Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors.

Bhattacharya S, Hall SE, Vaidehi N.

J Mol Biol. 2008 Oct 3;382(2):539-55. doi: 10.1016/j.jmb.2008.06.084. Epub 2008 Jul 7.

PMID:
18638482
4.

G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy.

Ding X, Zhao X, Watts A.

Biochem J. 2013 Mar 15;450(3):443-57. doi: 10.1042/BJ20121644. Review. Erratum in: Biochem J. 2013 Apr 15;451(2):343.

PMID:
23445222
5.

The role of conformational ensembles in ligand recognition in G-protein coupled receptors.

Niesen MJ, Bhattacharya S, Vaidehi N.

J Am Chem Soc. 2011 Aug 24;133(33):13197-204. doi: 10.1021/ja205313h. Epub 2011 Jul 29.

PMID:
21766860
6.

Elucidating Ligand-Modulated Conformational Landscape of GPCRs Using Cloud-Computing Approaches.

Shukla D, Lawrenz M, Pande VS.

Methods Enzymol. 2015;557:551-72. doi: 10.1016/bs.mie.2014.12.007. Epub 2015 Mar 24. Review.

PMID:
25950981
7.

Structure and dynamics of G-protein coupled receptors.

Vaidehi N, Bhattacharya S, Larsen AB.

Adv Exp Med Biol. 2014;796:37-54. doi: 10.1007/978-94-007-7423-0_3. Review.

PMID:
24158800
8.

Advances in methods to characterize ligand-induced ionic lock and rotamer toggle molecular switch in G protein-coupled receptors.

Xie XQ, Chowdhury A.

Methods Enzymol. 2013;520:153-74. doi: 10.1016/B978-0-12-391861-1.00007-1.

9.

Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.

Dong M, Koole C, Wootten D, Sexton PM, Miller LJ.

Br J Pharmacol. 2014 Mar;171(5):1085-101. doi: 10.1111/bph.12293. Review.

10.

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors.

Wheatley M, Simms J, Hawtin SR, Wesley VJ, Wootten D, Conner M, Lawson Z, Conner AC, Baker A, Cashmore Y, Kendrick R, Parslow RA.

Biochem Soc Trans. 2007 Aug;35(Pt 4):717-20. Review.

PMID:
17635132
11.

A conformation-equilibrium model captures ligand-ligand interactions and ligand-biased signalling by G-protein coupled receptors.

Roth S, Bruggeman FJ.

FEBS J. 2014 Oct;281(20):4659-71. doi: 10.1111/febs.12970. Epub 2014 Sep 17.

12.

The year in G protein-coupled receptor research.

Millar RP, Newton CL.

Mol Endocrinol. 2010 Jan;24(1):261-74. doi: 10.1210/me.2009-0473. Epub 2009 Dec 17. Review.

13.

Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.

Dalton JA, Lans I, Giraldo J.

BMC Bioinformatics. 2015 Apr 23;16:124. doi: 10.1186/s12859-015-0567-3.

14.

Allosteric inhibition of g-protein coupled receptor oligomerization: strategies and challenges for drug development.

Hurevich M, Talhami A, Shalev DE, Gilon C.

Curr Top Med Chem. 2014;14(15):1842-63. Review.

PMID:
25175995
15.

Activation of G-protein-coupled receptors: a common molecular mechanism.

Karnik SS, Gogonea C, Patil S, Saad Y, Takezako T.

Trends Endocrinol Metab. 2003 Nov;14(9):431-7. Review.

PMID:
14580763
16.

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.

Lee SM, Booe JM, Pioszak AA.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):196-205. doi: 10.1016/j.ejphar.2015.05.013. Epub 2015 May 14. Review.

17.

Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios.

Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY.

Methods Cell Biol. 2016;132:401-27. doi: 10.1016/bs.mcb.2015.10.005. Epub 2015 Dec 24.

PMID:
26928553
18.

Emerging opportunities for allosteric modulation of G-protein coupled receptors.

Wang CI, Lewis RJ.

Biochem Pharmacol. 2013 Jan 15;85(2):153-62. doi: 10.1016/j.bcp.2012.09.001. Epub 2012 Sep 11. Review.

PMID:
22975406
19.

Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.

Lu ZL, Coetsee M, White CD, Millar RP.

J Biol Chem. 2007 Jun 15;282(24):17921-9. Epub 2007 Apr 23.

20.

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X.

Pharmacol Rev. 2014 Feb 10;66(2):413-34. doi: 10.1124/pr.113.008052. Print 2014. Review.

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