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Items: 1 to 20 of 164

1.

Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.

Leal MC, Surace EI, Holgado MP, Ferrari CC, Tarelli R, Pitossi F, Wisniewski T, Castaño EM, Morelli L.

Biochim Biophys Acta. 2012 Feb;1823(2):227-35. doi: 10.1016/j.bbamcr.2011.09.014. Epub 2011 Oct 19.

2.

Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site.

Grogan SP, Olee T, Hiraoka K, Lotz MK.

Arthritis Rheum. 2008 Sep;58(9):2754-63. doi: 10.1002/art.23730.

3.

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.

Yang T, Arslanova D, Gu Y, Augelli-Szafran C, Xia W.

Mol Brain. 2008 Nov 4;1:15. doi: 10.1186/1756-6606-1-15.

4.

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.

PMID:
19355846
5.

Role of the RAM domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage.

Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E.

J Bone Miner Res. 2006 Aug;21(8):1317-26.

6.

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.

Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R.

Dev Biol. 2011 Apr 15;352(2):329-40. doi: 10.1016/j.ydbio.2011.01.038. Epub 2011 Feb 16.

7.

Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.

Wang R, Zhang YW, Zhang X, Liu R, Zhang X, Hong S, Xia K, Xia J, Zhang Z, Xu H.

FASEB J. 2006 Jun;20(8):1275-7. Epub 2006 Apr 27.

PMID:
16645044
8.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.

PMID:
16511867
9.

The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells.

Zhang Y, Lian JB, Stein JL, van Wijnen AJ, Stein GS.

J Cell Biochem. 2009 Oct 15;108(3):651-9. doi: 10.1002/jcb.22299.

10.

Glucocorticoids facilitate astrocytic amyloid-β peptide deposition by increasing the expression of APP and BACE1 and decreasing the expression of amyloid-β-degrading proteases.

Wang Y, Li M, Tang J, Song M, Xu X, Xiong J, Li J, Bai Y.

Endocrinology. 2011 Jul;152(7):2704-15. doi: 10.1210/en.2011-0145. Epub 2011 May 10.

PMID:
21558319
11.

Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F.

J Bone Miner Res. 2010 Apr;25(4):782-95. doi: 10.1359/jbmr.091024.

12.

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM.

J Neurosci. 2004 Dec 8;24(49):11120-6.

13.

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor.

Searfoss GH, Jordan WH, Calligaro DO, Galbreath EJ, Schirtzinger LM, Berridge BR, Gao H, Higgins MA, May PC, Ryan TP.

J Biol Chem. 2003 Nov 14;278(46):46107-16. Epub 2003 Aug 29.

14.

Functional analysis of Hes-1 in preadipocytes.

Ross DA, Hannenhalli S, Tobias JW, Cooch N, Shiekhattar R, Kadesch T.

Mol Endocrinol. 2006 Mar;20(3):698-705. Epub 2005 Nov 10.

PMID:
16282371
15.

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.

Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM.

FASEB J. 2004 May;18(7):902-4. Epub 2004 Mar 19.

PMID:
15033922
17.

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.

18.
19.

Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.

Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.

Mol Vis. 2003 May 1;9:179-83.

20.

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.

Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.

Mol Cell Biol. 2008 Jan;28(1):165-76. Epub 2007 Oct 29.

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