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Items: 1 to 20 of 111


Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement.

Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA.

Cell Host Microbe. 2011 Nov 17;10(5):497-506. doi: 10.1016/j.chom.2011.10.006. Epub 2011 Oct 27.


Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host response.

Polak D, Wilensky A, Shapira L, Halabi A, Goldstein D, Weiss EI, Houri-Haddad Y.

J Clin Periodontol. 2009 May;36(5):406-10. doi: 10.1111/j.1600-051X.2009.01393.x.


Microbiome: Tipping the balance.

Molloy S.

Nat Rev Microbiol. 2011 Dec 16;10(1):3. doi: 10.1038/nrmicro2723. No abstract available.


Divergence of the systemic immune response following oral infection with distinct strains of Porphyromonas gingivalis.

Marchesan JT, Morelli T, Lundy SK, Jiao Y, Lim S, Inohara N, Nunez G, Fox DA, Giannobile WV.

Mol Oral Microbiol. 2012 Dec;27(6):483-95. doi: 10.1111/omi.12001. Epub 2012 Sep 18.


Complement and dysbiosis in periodontal disease.

Hajishengallis G, Lambris JD.

Immunobiology. 2012 Nov;217(11):1111-6. doi: 10.1016/j.imbio.2012.07.007. Review.


Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis.

Maekawa T, Krauss JL, Abe T, Jotwani R, Triantafilou M, Triantafilou K, Hashim A, Hoch S, Curtis MA, Nussbaum G, Lambris JD, Hajishengallis G.

Cell Host Microbe. 2014 Jun 11;15(6):768-78. doi: 10.1016/j.chom.2014.05.012.


Role of complement in host-microbe homeostasis of the periodontium.

Hajishengallis G, Abe T, Maekawa T, Hajishengallis E, Lambris JD.

Semin Immunol. 2013 Feb;25(1):65-72. doi: 10.1016/j.smim.2013.04.004. Epub 2013 May 16. Review.


The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss.

Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G.

J Immunol. 2011 Jan 15;186(2):869-77. doi: 10.4049/jimmunol.1003252. Epub 2010 Dec 13.


Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.

Kuula H, Salo T, Pirilä E, Tuomainen AM, Jauhiainen M, Uitto VJ, Tjäderhane L, Pussinen PJ, Sorsa T.

Infect Immun. 2009 Feb;77(2):850-9. doi: 10.1128/IAI.00873-08. Epub 2008 Nov 24.


Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss.

Huang N, Shaik-Dasthagirisaheb YB, LaValley MP, Gibson FC 3rd.

Mol Oral Microbiol. 2015 Dec;30(6):438-50. doi: 10.1111/omi.12103. Epub 2015 Jun 9.


Periodontitis: a polymicrobial disruption of host homeostasis.

Darveau RP.

Nat Rev Microbiol. 2010 Jul;8(7):481-90. doi: 10.1038/nrmicro2337. Review.


Experimental periodontitis induced by Porphyromonas gingivalis does not alter the onset or severity of diabetes in mice.

Li H, Yang H, Ding Y, Aprecio R, Zhang W, Wang Q, Li Y.

J Periodontal Res. 2013 Oct;48(5):582-90. doi: 10.1111/jre.12041. Epub 2013 Jan 14.


Porphyromonas gingivalis: major periodontopathic pathogen overview.

Mysak J, Podzimek S, Sommerova P, Lyuya-Mi Y, Bartova J, Janatova T, Prochazkova J, Duskova J.

J Immunol Res. 2014;2014:476068. doi: 10.1155/2014/476068. Epub 2014 Mar 25. Review.


Pathogenic microbes and community service through manipulation of innate immunity.

Hajishengallis G, Krauss JL, Liang S, McIntosh ML, Lambris JD.

Adv Exp Med Biol. 2012;946:69-85. doi: 10.1007/978-1-4614-0106-3_5. Review.


The role of RgpA in the pathogenicity of Porphyromonas gingivalis in the murine periodontitis model.

Wilensky A, Polak D, Houri-Haddad Y, Shapira L.

J Clin Periodontol. 2013 Oct;40(10):924-32. doi: 10.1111/jcpe.12139. Epub 2013 Aug 4.


Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.

Abe T, Hosur KB, Hajishengallis E, Reis ES, Ricklin D, Lambris JD, Hajishengallis G.

J Immunol. 2012 Dec 1;189(11):5442-8. doi: 10.4049/jimmunol.1202339. Epub 2012 Oct 22.


Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches.

Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD.

Adv Exp Med Biol. 2015;865:57-74. doi: 10.1007/978-3-319-18603-0_4. Review.


Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.

McIntosh ML, Hajishengallis G.

Mol Oral Microbiol. 2012 Dec;27(6):449-57. doi: 10.1111/j.2041-1014.2012.00657.x. Epub 2012 Jul 5.

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