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Items: 1 to 20 of 336

1.

Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents.

Grippo PJ, Sandgren EP.

Int J Cancer. 2012 Sep 1;131(5):1243-8. doi: 10.1002/ijc.27322. Epub 2012 Jan 11.

2.

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.

Lewis BC, Klimstra DS, Varmus HE.

Genes Dev. 2003 Dec 15;17(24):3127-38. Epub 2003 Dec 17.

3.

KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.

Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, Eshleman JR.

Mol Cancer Res. 2009 Feb;7(2):230-6. doi: 10.1158/1541-7786.MCR-08-0206. Epub 2009 Feb 10.

4.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

5.

Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression.

Aguilar S, Corominas JM, Malats N, Pereira JA, Dufresne M, Real FX, Navarro P.

Am J Pathol. 2004 Oct;165(4):1129-39.

6.

Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma.

Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS.

Am J Surg Pathol. 2010 Apr;34(4):510-8. doi: 10.1097/PAS.0b013e3181cfcac7.

PMID:
20182344
7.

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.

Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF.

Oncogene. 2013 Apr 11;32(15):1950-8. doi: 10.1038/onc.2012.210. Epub 2012 Jun 4.

8.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
9.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.

J Pathol. 2012 Apr;226(5):723-34. doi: 10.1002/path.3017. Epub 2012 Jan 17.

PMID:
21984419
10.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

11.

Snail1 is required for the maintenance of the pancreatic acinar phenotype.

Loubat-Casanovas J, Peña R, Gonzàlez N, Alba-Castellón L, Rosell S, Francí C, Navarro P, García de Herreros A.

Oncotarget. 2016 Jan 26;7(4):4468-82. doi: 10.18632/oncotarget.6785.

12.

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.

Tanaka H, Fukamachi K, Futakuchi M, Alexander DB, Long N, Tamamushi S, Minami K, Seino S, Ohara H, Joh T, Tsuda H.

Cancer Sci. 2010 Feb;101(2):341-6. doi: 10.1111/j.1349-7006.2009.01410.x. Epub 2009 Oct 22.

13.

Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice.

Grippo PJ, Nowlin PS, Demeure MJ, Longnecker DS, Sandgren EP.

Cancer Res. 2003 May 1;63(9):2016-9.

14.
15.

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.

PMID:
21684285
16.

Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer.

Wauters E, Sanchez-Arévalo Lobo VJ, Pinho AV, Mawson A, Herranz D, Wu J, Cowley MJ, Colvin EK, Njicop EN, Sutherland RL, Liu T, Serrano M, Bouwens L, Real FX, Biankin AV, Rooman I.

Cancer Res. 2013 Apr 1;73(7):2357-67. doi: 10.1158/0008-5472.CAN-12-3359. Epub 2013 Jan 31.

17.

Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.

Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF.

Am J Pathol. 2007 Jul;171(1):263-73.

18.

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.

Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8. doi: 10.1073/pnas.0810097105. Epub 2008 Nov 21.

19.

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I.

J Pathol. 2009 Oct;219(2):205-13. doi: 10.1002/path.2585.

PMID:
19585519
20.

Developmental aspects of early pancreatic cancer.

Meszoely IM, Means AL, Scoggins CR, Leach SD.

Cancer J. 2001 Jul-Aug;7(4):242-50. Review.

PMID:
11561600

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