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Items: 1 to 20 of 311

1.

Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.

Stankowski LF Jr, Roberts DJ, Chen H, Lawlor T, McKeon M, Murli H, Thakur A, Xu Y.

Environ Mol Mutagen. 2011 Dec;52(9):738-47. doi: 10.1002/em.20692. Epub 2011 Oct 21.

PMID:
22020836
2.

Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.

Shi J, Krsmanovic L, Bruce S, Kelly T, Paranjpe M, Szabo K, Arevalo M, Atta-Safoh S, Debelie F, LaForce MK, Sly J, Springer S.

Environ Mol Mutagen. 2011 Dec;52(9):711-20. doi: 10.1002/em.20678. Epub 2011 Oct 4.

PMID:
21976072
3.

International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.

Lynch AM, Giddings A, Custer L, Gleason C, Henwood A, Aylott M, Kenny J.

Environ Mol Mutagen. 2011 Dec;52(9):699-710.

PMID:
22167885
4.

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.

Cammerer Z, Bhalli JA, Cao X, Coffing SL, Dickinson D, Dobo KL, Dobrovolsky VN, Engel M, Fiedler RD, Gunther WC, Heflich RH, Pearce MG, Shaddock JG, Shutsky T, Thiffeault CJ, Schuler M.

Environ Mol Mutagen. 2011 Dec;52(9):721-30.

PMID:
22167886
5.

Report on stage III Pig-a mutation assays using benzo[a]pyrene.

Bhalli JA, Shaddock JG, Pearce MG, Dobrovolsky VN, Cao X, Heflich RH, Vohr HW.

Environ Mol Mutagen. 2011 Dec;52(9):731-7. doi: 10.1002/em.20675. Epub 2011 Aug 29.

PMID:
22052432
6.

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.

Dertinger SD, Phonethepswath S, Weller P, Avlasevich S, Torous DK, Mereness JA, Bryce SM, Bemis JC, Bell S, Portugal S, Aylott M, MacGregor JT.

Environ Mol Mutagen. 2011 Dec;52(9):748-55. doi: 10.1002/em.20671. Epub 2011 Aug 29.

PMID:
22052433
7.

International Pig-a gene mutation assay trial: evaluation of transferability across 14 laboratories.

Dertinger SD, Phonethepswath S, Weller P, Nicolette J, Murray J, Sonders P, Vohr HW, Shi J, Krsmanovic L, Gleason C, Custer L, Henwood A, Sweder K, Stankowski LF Jr, Roberts DJ, Giddings A, Kenny J, Lynch AM, Defrain C, Nesslany F, van der Leede BJ, Van Doninck T, Schuermans A, Tanaka K, Hiwata Y, Tajima O, Wilde E, Elhajouji A, Gunther WC, Thiffeault CJ, Shutsky TJ, Fiedler RD, Kimoto T, Bhalli JA, Heflich RH, MacGregor JT.

Environ Mol Mutagen. 2011 Dec;52(9):690-8. doi: 10.1002/em.20672. Epub 2011 Sep 11.

PMID:
21910140
8.

Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane.

Stankowski LF Jr, Aardema MJ, Lawlor TE, Pant K, Roy S, Xu Y, Elbekai R.

Mutagenesis. 2015 May;30(3):335-42. doi: 10.1093/mutage/gev013. Epub 2015 May 1.

9.

Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.

Zhou C, Zhang M, Huang P, Tu H, Wang Z, Dertinger SD, Torous DK, Chang Y.

Environ Mol Mutagen. 2014 Dec;55(9):735-40. doi: 10.1002/em.21893. Epub 2014 Aug 14.

PMID:
25124805
10.

Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.

Gunther WC, Coffing SL, Dickinson DA, Engel ME, Fiedler RD, O'Lone SD, Sanok KE, Thiffeault CJ, Shutsky TJ, Schuler MJ, Dobo KL.

Environ Mol Mutagen. 2014 Jul;55(6):492-9. doi: 10.1002/em.21863. Epub 2014 Mar 6.

PMID:
24599777
11.

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.

Dertinger SD, Phonethepswath S, Avlasevich SL, Torous DK, Mereness J, Cottom J, Bemis JC, Macgregor JT.

Environ Mol Mutagen. 2014 May;55(4):299-308. doi: 10.1002/em.21846. Epub 2014 Jan 21.

PMID:
24449360
12.

Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.

Kimoto T, Chikura S, Suzuki K, Kobayashi Xm, Itano Y, Horibata K, Honma M, Dobrovolsky VN, Heflich RH, Miura D, Kasahara Y.

Environ Mol Mutagen. 2011 Dec;52(9):774-83.

PMID:
22167888
13.

In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.

Torous DK, Phonethepswath S, Avlasevich SL, Mereness J, Bryce SM, Bemis JC, Weller P, Bell S, Gleason C, Custer LL, MacGregor JT, Dertinger SD.

Environ Mol Mutagen. 2012 Jul;53(6):420-8. doi: 10.1002/em.21709. Epub 2012 Jun 22.

PMID:
22730284
14.

Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.

Roberts DJ, McKeon M, Xu Y, Stankowski LF Jr.

Environ Mol Mutagen. 2016 Jan;57(1):17-27. doi: 10.1002/em.21981. Epub 2015 Sep 26.

PMID:
26407646
15.

Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse.

Lemieux CL, Douglas GR, Gingerich J, Phonethepswath S, Torous DK, Dertinger SD, Phillips DH, Arlt VM, White PA.

Environ Mol Mutagen. 2011 Dec;52(9):756-65. doi: 10.1002/em.20688. Epub 2011 Oct 4.

16.

In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

Hayashi M, MacGregor JT, Gatehouse DG, Blakey DH, Dertinger SD, Abramsson-Zetterberg L, Krishna G, Morita T, Russo A, Asano N, Suzuki H, Ohyama W, Gibson D; In Vivo Micronucleus Assay Working Group, IWGT.

Mutat Res. 2007 Feb 3;627(1):10-30. Epub 2006 Dec 6.

PMID:
17157053
17.

Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody.

Kimoto T, Horibata K, Chikura S, Hashimoto K, Itoh S, Sanada H, Muto S, Uno Y, Yamada M, Honma M.

Mutat Res. 2013 Aug 15;755(2):126-34. doi: 10.1016/j.mrgentox.2013.06.006. Epub 2013 Jun 20.

PMID:
23792374
18.

Evaluation of a multi-endpoint assay in rats, combining the bone-marrow micronucleus test, the Comet assay and the flow-cytometric peripheral blood micronucleus test.

Bowen DE, Whitwell JH, Lillford L, Henderson D, Kidd D, Mc Garry S, Pearce G, Beevers C, Kirkland DJ; Work conducted at Covance Laboratories Ltd., Harrogate.

Mutat Res. 2011 May 18;722(1):7-19. doi: 10.1016/j.mrgentox.2011.02.009. Epub 2011 Feb 25.

PMID:
21356328
19.

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.

Avlasevich SL, Phonethepswath S, Labash C, Carlson K, Torous DK, Cottom J, Bemis JC, MacGregor JT, Dertinger SD.

Environ Mol Mutagen. 2014 Jun;55(5):400-6. doi: 10.1002/em.21862. Epub 2014 Feb 27.

PMID:
24574022
20.

Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies.

Rothfuss A, O'Donovan M, De Boeck M, Brault D, Czich A, Custer L, Hamada S, Plappert-Helbig U, Hayashi M, Howe J, Kraynak AR, van der Leede BJ, Nakajima M, Priestley C, Thybaud V, Saigo K, Sawant S, Shi J, Storer R, Struwe M, Vock E, Galloway S.

Mutat Res. 2010 Sep 30;702(1):40-69. doi: 10.1016/j.mrgentox.2010.07.006. Epub 2010 Jul 23.

PMID:
20656055

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