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The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia.

Ahlquist DA, Taylor WR, Mahoney DW, Zou H, Domanico M, Thibodeau SN, Boardman LA, Berger BM, Lidgard GP.

Clin Gastroenterol Hepatol. 2012 Mar;10(3):272-7.e1. doi: 10.1016/j.cgh.2011.10.008. Epub 2011 Oct 20.


Clinical performance of an automated stool DNA assay for detection of colorectal neoplasia.

Lidgard GP, Domanico MJ, Bruinsma JJ, Light J, Gagrat ZD, Oldham-Haltom RL, Fourrier KD, Allawi H, Yab TC, Taylor WR, Simonson JA, Devens M, Heigh RI, Ahlquist DA, Berger BM.

Clin Gastroenterol Hepatol. 2013 Oct;11(10):1313-8. doi: 10.1016/j.cgh.2013.04.023. Epub 2013 Apr 29.


Next-generation stool DNA test accurately detects colorectal cancer and large adenomas.

Ahlquist DA, Zou H, Domanico M, Mahoney DW, Yab TC, Taylor WR, Butz ML, Thibodeau SN, Rabeneck L, Paszat LF, Kinzler KW, Vogelstein B, Bjerregaard NC, Laurberg S, Sørensen HT, Berger BM, Lidgard GP.

Gastroenterology. 2012 Feb;142(2):248-56; quiz e25-6. doi: 10.1053/j.gastro.2011.10.031. Epub 2011 Nov 4.


Performance of a second-generation methylated SEPT9 test in detecting colorectal neoplasm.

Jin P, Kang Q, Wang X, Yang L, Yu Y, Li N, He YQ, Han X, Hang J, Zhang J, Song L, Han Y, Sheng JQ.

J Gastroenterol Hepatol. 2015 May;30(5):830-3. doi: 10.1111/jgh.12855.


Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer.

Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, Fang JC, Samowitz WS, Heichman KA.

BMC Med. 2011 Dec 14;9:133. doi: 10.1186/1741-7015-9-133.


Detection of colorectal serrated polyps by stool DNA testing: comparison with fecal immunochemical testing for occult blood (FIT).

Heigh RI, Yab TC, Taylor WR, Hussain FT, Smyrk TC, Mahoney DW, Domanico MJ, Berger BM, Lidgard GP, Ahlquist DA.

PLoS One. 2014 Jan 20;9(1):e85659. doi: 10.1371/journal.pone.0085659. eCollection 2014.


Multitarget stool DNA tests increases colorectal cancer screening among previously noncompliant Medicare patients.

Prince M, Lester L, Chiniwala R, Berger B.

World J Gastroenterol. 2017 Jan 21;23(3):464-471. doi: 10.3748/wjg.v23.i3.464.


Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided colon cancers.

Tóth K, Sipos F, Kalmár A, Patai AV, Wichmann B, Stoehr R, Golcher H, Schellerer V, Tulassay Z, Molnár B.

PLoS One. 2012;7(9):e46000. doi: 10.1371/journal.pone.0046000. Epub 2012 Sep 25.


Screening for Colorectal Cancer: A Systematic Review for the U.S. Preventive Services Task Force [Internet].

Lin JS, Piper MA, Perdue LA, Rutter C, Webber EM, O’Connor E, Smith N, Whitlock EP.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Jun.


Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer.

Church TR, Wandell M, Lofton-Day C, Mongin SJ, Burger M, Payne SR, Castaños-Vélez E, Blumenstein BA, Rösch T, Osborn N, Snover D, Day RW, Ransohoff DF; PRESEPT Clinical Study Steering Committee, Investigators and Study Team.

Gut. 2014 Feb;63(2):317-25. doi: 10.1136/gutjnl-2012-304149. Epub 2013 Feb 13.


Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma.

Potter NT, Hurban P, White MN, Whitlock KD, Lofton-Day CE, Tetzner R, Koenig T, Quigley NB, Weiss G.

Clin Chem. 2014 Sep;60(9):1183-91. doi: 10.1373/clinchem.2013.221044. Epub 2014 Jun 17.


A novel multitarget stool DNA test for colorectal cancer screening.

Malik P.

Postgrad Med. 2016;128(2):268-72. doi: 10.1080/00325481.2016.1135035. Epub 2016 Jan 12.


Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study.

Ørntoft MB, Nielsen HJ, Ørntoft TF, Andersen CL; Danish Study Group on Early Detection of Colorectal Cancer.

BMC Cancer. 2015 Oct 29;15:819. doi: 10.1186/s12885-015-1832-6.


Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People.

Redwood DG, Asay ED, Blake ID, Sacco PE, Christensen CM, Sacco FD, Tiesinga JJ, Devens ME, Alberts SR, Mahoney DW, Yab TC, Foote PH, Smyrk TC, Provost EM, Ahlquist DA.

Mayo Clin Proc. 2016 Jan;91(1):61-70. doi: 10.1016/j.mayocp.2015.10.008. Epub 2015 Oct 28.


A simplified, noninvasive stool DNA test for colorectal cancer detection.

Itzkowitz S, Brand R, Jandorf L, Durkee K, Millholland J, Rabeneck L, Schroy PC 3rd, Sontag S, Johnson D, Markowitz S, Paszat L, Berger BM.

Am J Gastroenterol. 2008 Nov;103(11):2862-70. doi: 10.1111/j.1572-0241.2008.02088.x. Epub 2008 Aug 27.


The Relationship between the Methylated Septin-9 DNA Blood Test and Stool Occult Blood Test for Diagnosing Colorectal Cancer in Taiwanese People.

Chen CH, Yan SL, Yang TH, Chen SF, Yeh YH, Ou JJ, Lin CH, Lee YT, Chen CH.

J Clin Lab Anal. 2017 Jan;31(1). doi: 10.1002/jcla.22013. Epub 2016 Jul 8.


Detection of methylated septin 9 in tissue and plasma of colorectal patients with neoplasia and the relationship to the amount of circulating cell-free DNA.

Tóth K, Wasserkort R, Sipos F, Kalmár A, Wichmann B, Leiszter K, Valcz G, Juhász M, Miheller P, Patai ÁV, Tulassay Z, Molnár B.

PLoS One. 2014 Dec 19;9(12):e115415. doi: 10.1371/journal.pone.0115415. eCollection 2014.


Diagnostic Accuracy of a Qualitative Fecal Immunochemical Test Varies With Location of Neoplasia But Not Number of Specimens.

Wong MC, Ching JY, Chan VC, Lam TY, Shum JP, Luk AK, Wong SS, Ng SC, Ng SS, Wu JC, Chan FK, Sung JJ.

Clin Gastroenterol Hepatol. 2015 Aug;13(8):1472-9. doi: 10.1016/j.cgh.2015.02.021. Epub 2015 Feb 24.


Comparative Effectiveness and Cost Effectiveness of a Multitarget Stool DNA Test to Screen for Colorectal Neoplasia.

Ladabaum U, Mannalithara A.

Gastroenterology. 2016 Sep;151(3):427-439.e6. doi: 10.1053/j.gastro.2016.06.003. Epub 2016 Jun 14.


Stool Investigations for Colorectal Cancer Screening: From Occult Blood Test to DNA Analysis.

Iannone A, Losurdo G, Pricci M, Girardi B, Massaro A, Principi M, Barone M, Ierardi E, Di Leo A.

J Gastrointest Cancer. 2016 Jun;47(2):143-51. doi: 10.1007/s12029-016-9810-z. Review.


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