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Items: 1 to 20 of 142

1.

Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching.

Fragall CT, Adams AM, Johnsen RD, Kole R, Fletcher S, Wilton SD.

BMC Med Genet. 2011 Oct 20;12:141. doi: 10.1186/1471-2350-12-141.

2.

Multiple exon skipping strategies to by-pass dystrophin mutations.

Adkin CF, Meloni PL, Fletcher S, Adams AM, Muntoni F, Wong B, Wilton SD.

Neuromuscul Disord. 2012 Apr;22(4):297-305. doi: 10.1016/j.nmd.2011.10.007. Epub 2011 Dec 17.

3.

Optimizing splice-switching oligomer sequences using 2'-O-methyl phosphorothioate chemistry.

Adkin C, Fletcher S, Wilton SD.

Methods Mol Biol. 2012;867:169-88. doi: 10.1007/978-1-61779-767-5_11.

PMID:
22454061
4.

Skipping multiple exons of dystrophin transcripts using cocktail antisense oligonucleotides.

Echigoya Y, Yokota T.

Nucleic Acid Ther. 2014 Feb;24(1):57-68. doi: 10.1089/nat.2013.0451. Epub 2013 Dec 31. Review.

PMID:
24380394
5.

Optimizing antisense oligonucleotides using phosphorodiamidate morpholino oligomers.

Popplewell LJ, Malerba A, Dickson G.

Methods Mol Biol. 2012;867:143-67. doi: 10.1007/978-1-61779-767-5_10.

PMID:
22454060
6.

Characterization of a complex Duchenne muscular dystrophy-causing dystrophin gene inversion and restoration of the reading frame by induced exon skipping.

Madden HR, Fletcher S, Davis MR, Wilton SD.

Hum Mutat. 2009 Jan;30(1):22-8. doi: 10.1002/humu.20806.

PMID:
18570328
7.

Splice modification to restore functional dystrophin synthesis in Duchenne muscular dystrophy.

Wilton SD, Fletcher S.

Curr Pharm Des. 2010;16(8):988-1001. Review.

PMID:
20041827
8.

Personalized exon skipping strategies to address clustered non-deletion dystrophin mutations.

Forrest S, Meloni PL, Muntoni F, Kim J, Fletcher S, Wilton SD.

Neuromuscul Disord. 2010 Dec;20(12):810-6. doi: 10.1016/j.nmd.2010.07.276.

9.

Personalised genetic intervention for Duchenne muscular dystrophy: antisense oligomers and exon skipping.

Mitrpant C, Fletcher S, Wilton SD.

Curr Mol Pharmacol. 2009 Jan;2(1):110-21. Review.

PMID:
20021451
10.

Rational design of antisense oligomers to induce dystrophin exon skipping.

Mitrpant C, Adams AM, Meloni PL, Muntoni F, Fletcher S, Wilton SD.

Mol Ther. 2009 Aug;17(8):1418-26. doi: 10.1038/mt.2009.49. Epub 2009 Mar 17.

11.

Bioinformatic and functional optimization of antisense phosphorodiamidate morpholino oligomers (PMOs) for therapeutic modulation of RNA splicing in muscle.

Popplewell LJ, Graham IR, Malerba A, Dickson G.

Methods Mol Biol. 2011;709:153-78. doi: 10.1007/978-1-61737-982-6_10.

PMID:
21194027
12.

Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse.

Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD.

Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19.

13.

Screening for antisense modulation of dystrophin pre-mRNA splicing.

Dickson G, Hill V, Graham IR.

Neuromuscul Disord. 2002 Oct;12 Suppl 1:S67-70. Review.

PMID:
12206799
14.

Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy.

Aartsma-Rus A, Janson AA, van Ommen GJ, van Deutekom JC.

BMC Med Genet. 2007 Jul 5;8:43.

15.

Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and chemistries.

Adams AM, Harding PL, Iversen PL, Coleman C, Fletcher S, Wilton SD.

BMC Mol Biol. 2007 Jul 2;8:57.

16.

Antisense oligonucleotide-induced exon skipping across the human dystrophin gene transcript.

Wilton SD, Fall AM, Harding PL, McClorey G, Coleman C, Fletcher S.

Mol Ther. 2007 Jul;15(7):1288-96. Epub 2007 Feb 6.

17.

Optimizing RNA/ENA chimeric antisense oligonucleotides using in vitro splicing.

Takeshima Y, Yagi M, Matsuo M.

Methods Mol Biol. 2012;867:131-41. doi: 10.1007/978-1-61779-767-5_9.

PMID:
22454059
18.

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides.

Wilton SD, Lloyd F, Carville K, Fletcher S, Honeyman K, Agrawal S, Kole R.

Neuromuscul Disord. 1999 Jul;9(5):330-8.

PMID:
10407856
19.

Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD.

McClorey G, Moulton HM, Iversen PL, Fletcher S, Wilton SD.

Gene Ther. 2006 Oct;13(19):1373-81. Epub 2006 May 25.

PMID:
16724091
20.

Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse.

Mann CJ, Honeyman K, Cheng AJ, Ly T, Lloyd F, Fletcher S, Morgan JE, Partridge TA, Wilton SD.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):42-7.

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