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Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis.

Arden C, Petrie JL, Tudhope SJ, Al-Oanzi Z, Claydon AJ, Beynon RJ, Towle HC, Agius L.

Diabetes. 2011 Dec;60(12):3110-20. doi: 10.2337/db11-0061. Epub 2011 Oct 19.


High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload.

Agius L.

Biochem Pharmacol. 2013 Feb 1;85(3):306-12. doi: 10.1016/j.bcp.2012.09.019. Epub 2012 Sep 26.


Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice.

Jo SH, Kim MY, Park JM, Kim TH, Ahn YH.

Diabetologia. 2013 Dec;56(12):2723-32. doi: 10.1007/s00125-013-3050-6. Epub 2013 Sep 14.


Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.

Rees MG, Wincovitch S, Schultz J, Waterstradt R, Beer NL, Baltrusch S, Collins FS, Gloyn AL.

Diabetologia. 2012 Jan;55(1):114-22. doi: 10.1007/s00125-011-2348-5. Epub 2011 Oct 25.


Role of glucokinase in the subcellular localization of glucokinase regulatory protein.

Jin L, Guo T, Li Z, Lei Z, Li H, Mao Y, Wang X, Zhou N, Zhang Y, Hu R, Zhang X, Niu G, Irwin DM, Tan H.

Int J Mol Sci. 2015 Apr 2;16(4):7377-93. doi: 10.3390/ijms16047377.


Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes.

Ge Y, Zhang Y, Li R, Chen W, Li Y, Chen G.

Int J Biol Sci. 2011;7(5):673-84. Epub 2011 May 24.


Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver.

Kim MY, Jo SH, Park JM, Kim TH, Im SS, Ahn YH.

Diabetologia. 2013 Mar;56(3):635-43. doi: 10.1007/s00125-012-2807-7. Epub 2012 Dec 27.


The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, Gloyn AL.

Hum Mol Genet. 2009 Nov 1;18(21):4081-8. doi: 10.1093/hmg/ddp357. Epub 2009 Jul 30.


Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.

Hansmannel F, Mordier S, Iynedjian PB.

Biochem J. 2006 Oct 15;399(2):275-83. Erratum in: Biochem J. 2008 May 1;411(3):697.


Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.

Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L.

Biochem J. 2012 Apr 1;443(1):111-23. doi: 10.1042/BJ20111280.


Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.

Al-Oanzi ZH, Fountana S, Moonira T, Tudhope SJ, Petrie JL, Alshawi A, Patman G, Arden C, Reeves HL, Agius L.

Diabetes Obes Metab. 2017 Feb 16. doi: 10.1111/dom.12910. [Epub ahead of print]


A hepatic protein modulates glucokinase activity in fish and avian liver: a comparative study.

Polakof S, Míguez JM, Soengas JL.

J Comp Physiol B. 2009 Jul;179(5):643-52. doi: 10.1007/s00360-009-0346-4. Epub 2009 Feb 27.


Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.

Bechmann LP, Gastaldelli A, Vetter D, Patman GL, Pascoe L, Hannivoort RA, Lee UE, Fiel I, Muñoz U, Ciociaro D, Lee YM, Buzzigoli E, Miele L, Hui KY, Bugianesi E, Burt AD, Day CP, Mari A, Agius L, Walker M, Friedman SL, Reeves HL.

Hepatology. 2012 Apr;55(4):1083-93. doi: 10.1002/hep.24793. Epub 2012 Mar 1.


Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver.

Hiskett EK, Suwitheechon OU, Lindbloom-Hawley S, Boyle DL, Schermerhorn T.

Vet Res Commun. 2009 Mar;33(3):227-40. doi: 10.1007/s11259-008-9171-6. Epub 2008 Sep 9.


Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

Tam CH, Ma RC, So WY, Wang Y, Lam VK, Germer S, Martin M, Chan JC, Ng MC.

Diabetes. 2009 Mar;58(3):765-9. doi: 10.2337/db08-1277. Epub 2008 Dec 10.


Evolution of glucose utilization: glucokinase and glucokinase regulator protein.

Irwin DM, Tan H.

Mol Phylogenet Evol. 2014 Jan;70:195-203. doi: 10.1016/j.ympev.2013.09.016. Epub 2013 Sep 25. Review.


Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.


The rate of production of uric acid by hepatocytes is a sensitive index of compromised cell ATP homeostasis.

Petrie JL, Patman GL, Sinha I, Alexander TD, Reeves HL, Agius L.

Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1255-65. doi: 10.1152/ajpendo.00214.2013. Epub 2013 Sep 17.

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