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Items: 1 to 20 of 105

1.

A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.

Suleman F, Gualeni B, Gregson HJ, Leighton MP, Piróg KA, Edwards S, Holden P, Boot-Handford RP, Briggs MD.

Hum Mutat. 2012 Jan;33(1):218-31. doi: 10.1002/humu.21631. Epub 2011 Nov 17.

2.

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.

Piróg-Garcia KA, Meadows RS, Knowles L, Heinegård D, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD.

Hum Mol Genet. 2007 Sep 1;16(17):2072-88. Epub 2007 Jun 22.

3.
4.

Chondrocyte cell death and intracellular distribution of COMP and type IX collagen in the pseudoachondroplasia growth plate.

Hecht JT, Makitie O, Hayes E, Haynes R, Susic M, Montufar-Solis D, Duke PJ, Cole WG.

J Orthop Res. 2004 Jul;22(4):759-67.

5.

Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.

Piróg KA, Irman A, Young S, Halai P, Bell PA, Boot-Handford RP, Briggs MD.

PLoS One. 2014 Feb 18;9(2):e85145. doi: 10.1371/journal.pone.0085145. eCollection 2014.

6.

Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.

Posey KL, Coustry F, Veerisetty AC, Liu P, Alcorn JL, Hecht JT.

Am J Pathol. 2012 Feb;180(2):727-37. doi: 10.1016/j.ajpath.2011.10.035. Epub 2011 Dec 7.

7.

Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues.

Hecht JT, Deere M, Putnam E, Cole W, Vertel B, Chen H, Lawler J.

Matrix Biol. 1998 Aug;17(4):269-78.

PMID:
9749943
8.

An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype.

Posey KL, Veerisetty AC, Liu P, Wang HR, Poindexter BJ, Bick R, Alcorn JL, Hecht JT.

Am J Pathol. 2009 Oct;175(4):1555-63. doi: 10.2353/ajpath.2009.090184. Epub 2009 Sep 17.

9.

COMP mutations, chondrocyte function and cartilage matrix.

Hecht JT, Hayes E, Haynes R, Cole WG.

Matrix Biol. 2005 Jan;23(8):525-33. Epub 2004 Nov 18.

PMID:
15694129
10.

D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.

Coustry F, Posey KL, Liu P, Alcorn JL, Hecht JT.

Am J Pathol. 2012 Feb;180(2):738-48. doi: 10.1016/j.ajpath.2011.10.033. Epub 2011 Dec 7.

11.

Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes.

Hecht JT, Montufar-Solis D, Decker G, Lawler J, Daniels K, Duke PJ.

Matrix Biol. 1998 Dec;17(8-9):625-33.

PMID:
9923655
12.

Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH.

Chen TL, Stevens JW, Cole WG, Hecht JT, Vertel BM.

Matrix Biol. 2004 Nov;23(7):433-44.

PMID:
15579310
13.

COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.

Chen TL, Posey KL, Hecht JT, Vertel BM.

J Cell Biochem. 2008 Feb 15;103(3):778-87.

PMID:
17570134
14.

Unique matrix structure in the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes.

Merritt TM, Bick R, Poindexter BJ, Alcorn JL, Hecht JT.

Am J Pathol. 2007 Jan;170(1):293-300.

15.

Calreticulin, PDI, Grp94 and BiP chaperone proteins are associated with retained COMP in pseudoachondroplasia chondrocytes.

Hecht JT, Hayes E, Snuggs M, Decker G, Montufar-Solis D, Doege K, Mwalle F, Poole R, Stevens J, Duke PJ.

Matrix Biol. 2001 Jul;20(4):251-62.

PMID:
11470401
16.

Chondrocyte-specific pathology during skeletal growth and therapeutics in a murine model of pseudoachondroplasia.

Posey KL, Coustry F, Veerisetty AC, Liu P, Alcorn JL, Hecht JT.

J Bone Miner Res. 2014;29(5):1258-68. doi: 10.1002/jbmr.2139.

17.

Expression of PSACH-associated mutant COMP in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP.

Weirich C, Keene DR, Kirsch K, Heil M, Neumann E, Dinser R.

Matrix Biol. 2007 May;26(4):314-23. Epub 2007 Jan 18.

PMID:
17307347
19.

MED and PSACH COMP mutations affect chondrogenesis in chicken limb bud micromass cultures.

Roman-Blas J, Dion AS, Seghatoleslami MR, Giunta K, Oca P, Jimenez SA, Williams CJ.

J Cell Physiol. 2010 Sep;224(3):817-26. doi: 10.1002/jcp.22185.

PMID:
20578249
20.

Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia.

Posey KL, Coustry F, Veerisetty AC, Hossain M, Alcorn JL, Hecht JT.

Hum Mol Genet. 2015 Jul 15;24(14):3918-28. doi: 10.1093/hmg/ddv122. Epub 2015 Apr 9.

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