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Items: 1 to 20 of 109

1.

N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C.

Nat Chem Biol. 2011 Oct 16;7(12):885-7. doi: 10.1038/nchembio.687. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

2.

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.

Fu Y, Jia G, Pang X, Wang RN, Wang X, Li CJ, Smemo S, Dai Q, Bailey KA, Nobrega MA, Han KL, Cui Q, He C.

Nat Commun. 2013;4:1798. doi: 10.1038/ncomms2822.

3.

N6-methyl-adenosine modification in messenger and long non-coding RNA.

Pan T.

Trends Biochem Sci. 2013 Apr;38(4):204-9. doi: 10.1016/j.tibs.2012.12.006. Review.

4.

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, Wang X, Huang CM, Fu Y, Ge XM, Song SH, Jeong HS, Yanagisawa H, Niu Y, Jia GF, Wu W, Tong WM, Okamoto A, He C, Rendtlew Danielsen JM, Wang XJ, Yang YG.

Cell Res. 2014 Dec;24(12):1403-19. doi: 10.1038/cr.2014.151.

5.

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5.

Huang Y, Yan J, Li Q, Li J, Gong S, Zhou H, Gan J, Jiang H, Jia GF, Luo C, Yang CG.

Nucleic Acids Res. 2015 Jan;43(1):373-84. doi: 10.1093/nar/gku1276.

6.

A link between FTO, ghrelin, and impaired brain food-cue responsivity.

Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Rüther UU, Brüning JC, Withers DJ, Zelaya FO, Batterham RL.

J Clin Invest. 2013 Aug;123(8):3539-51. doi: 10.1172/JCI44403.

7.

Reversible RNA adenosine methylation in biological regulation.

Jia G, Fu Y, He C.

Trends Genet. 2013 Feb;29(2):108-15. doi: 10.1016/j.tig.2012.11.003. Review.

8.

FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice.

Chen J, Zhou X, Wu W, Wang X, Wang Y.

J Physiol Biochem. 2015 Sep;71(3):405-13. doi: 10.1007/s13105-015-0420-1.

PMID:
26078098
9.

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.

Zhang M, Zhang Y, Ma J, Guo F, Cao Q, Zhang Y, Zhou B, Chai J, Zhao W, Zhao R.

PLoS One. 2015 Jul 28;10(7):e0133788. doi: 10.1371/journal.pone.0133788.

10.

The dynamic epitranscriptome: N6-methyladenosine and gene expression control.

Meyer KD, Jaffrey SR.

Nat Rev Mol Cell Biol. 2014 May;15(5):313-26. doi: 10.1038/nrm3785. Review.

11.

Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5.

Shen F, Huang W, Huang JT, Xiong J, Yang Y, Wu K, Jia GF, Chen J, Feng YQ, Yuan BF, Liu SM.

J Clin Endocrinol Metab. 2015 Jan;100(1):E148-54. doi: 10.1210/jc.2014-1893.

PMID:
25303482
12.

Diazirine photocrosslinking recruits activated FTO demethylase complexes for specific N(6)-methyladenosine recognition.

Jeong HS, Hayashi G, Okamoto A.

ACS Chem Biol. 2015 Jun 19;10(6):1450-5. doi: 10.1021/cb5010096.

PMID:
25751089
13.

Dynamic RNA modifications in disease.

Klungland A, Dahl JA.

Curr Opin Genet Dev. 2014 Jun;26:47-52. doi: 10.1016/j.gde.2014.05.006. Review.

PMID:
25005745
14.

Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR, Qian SB.

Nature. 2015 Oct 22;526(7574):591-4. doi: 10.1038/nature15377.

15.
16.

FTO and obesity: mechanisms of association.

Zhao X, Yang Y, Sun BF, Zhao YL, Yang YG.

Curr Diab Rep. 2014;14(5):486. doi: 10.1007/s11892-014-0486-0. Review.

PMID:
24627050
17.

mRNA m⁶A methylation downregulates adipogenesis in porcine adipocytes.

Wang X, Zhu L, Chen J, Wang Y.

Biochem Biophys Res Commun. 2015 Apr 3;459(2):201-7. doi: 10.1016/j.bbrc.2015.02.048.

PMID:
25725156
18.

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate.

Ma M, Harding HP, O'Rahilly S, Ron D, Yeo GS.

Biochem J. 2012 Jun 1;444(2):183-7. doi: 10.1042/BJ20120065.

PMID:
22435707
19.

FTO, RNA epigenetics and epilepsy.

Rowles J, Wong M, Powers R, Olsen M.

Epigenetics. 2012 Oct;7(10):1094-7. doi: 10.4161/epi.21977.

20.

Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Chen B, Ye F, Yu L, Jia G, Huang X, Zhang X, Peng S, Chen K, Wang M, Gong S, Zhang R, Yin J, Li H, Yang Y, Liu H, Zhang J, Zhang H, Zhang A, Jiang H, Luo C, Yang CG.

J Am Chem Soc. 2012 Oct 31;134(43):17963-71. doi: 10.1021/ja3064149.

PMID:
23045983

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