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Items: 1 to 20 of 101


Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents.

Crowell SR, Amin SG, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):365-76. doi: 10.1016/j.taap.2011.09.020. Epub 2011 Sep 29.


In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes.

Crowell SR, Hanson-Drury S, Williams DE, Corley RA.

Toxicol Lett. 2014 Jul 3;228(1):48-55. doi: 10.1016/j.toxlet.2014.04.004. Epub 2014 Apr 21.


In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes.

Smith JN, Mehinagic D, Nag S, Crowell SR, Corley RA.

Toxicol Lett. 2017 Mar 5;269:23-32. doi: 10.1016/j.toxlet.2017.01.008. Epub 2017 Jan 21.


Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice.

Crowell SR, Sharma AK, Amin S, Soelberg JJ, Sadler NC, Wright AT, Baird WM, Williams DE, Corley RA.

Toxicol Sci. 2013 Sep;135(1):48-62. doi: 10.1093/toxsci/kft124. Epub 2013 Jun 6.


Understanding the linked kinetics of benzo(a)pyrene and 3-hydroxybenzo(a)pyrene biomarker of exposure using physiologically-based pharmacokinetic modelling in rats.

Heredia-Ortiz R, Bouchard M.

J Pharmacokinet Pharmacodyn. 2013 Dec;40(6):669-82. doi: 10.1007/s10928-013-9338-9. Epub 2013 Oct 29.


Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling.

Campbell J, Franzen A, Van Landingham C, Lumpkin M, Crowell S, Meredith C, Loccisano A, Gentry R, Clewell H.

Inhal Toxicol. 2016 Sep;28(11):520-35. doi: 10.1080/08958378.2016.1214768.


Human in Vivo Pharmacokinetics of [(14)C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing.

Madeen E, Corley RA, Crowell S, Turteltaub K, Ognibene T, Malfatti M, McQuistan TJ, Garrard M, Sudakin D, Williams DE.

Chem Res Toxicol. 2015 Jan 20;28(1):126-34. doi: 10.1021/tx5003996. Epub 2014 Dec 10.


Use of physiologically-based pharmacokinetic modeling to simulate the profiles of 3-hydroxybenzo(a)pyrene in workers exposed to polycyclic aromatic hydrocarbons.

Heredia Ortiz R, Maître A, Barbeau D, Lafontaine M, Bouchard M.

PLoS One. 2014 Jul 17;9(7):e102570. doi: 10.1371/journal.pone.0102570. eCollection 2014.


Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay.

Machala M, Vondrácek J, Bláha L, Ciganek M, Neca JV.

Mutat Res. 2001 Oct 18;497(1-2):49-62.


Quantitative analysis of 3-OHB[a]P and (+)-anti-BPDE as biomarkers of B[a]P exposure in rats.

Lin Q, Xiao-Chen L, Bo Y, Na L, Min S, Gang C, Hui L, Jie Z, Fa-Sheng L.

Biomed Chromatogr. 2016 Mar;30(3):474-83. doi: 10.1002/bmc.3574. Epub 2015 Oct 20.


Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry.

Madeen EP, Ognibene TJ, Corley RA, McQuistan TJ, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE.

Chem Res Toxicol. 2016 Oct 17;29(10):1641-1650. Epub 2016 Sep 9.


Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS.

Harper TA Jr, Morré J, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, Williams DE.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Apr;782:51-6. doi: 10.1016/j.mrgentox.2015.03.007. Epub 2015 Mar 12.


Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver.

Elovaara E, Mikkola J, Stockmann-Juvala H, Luukkanen L, Keski-Hynnilä H, Kostiainen R, Pasanen M, Pelkonen O, Vainio H.

Arch Toxicol. 2007 Mar;81(3):169-82. Epub 2006 Aug 12.


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