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Items: 1 to 20 of 167

1.

Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.

Sharlow ER, Mustata Wilson G, Close D, Leimgruber S, Tandon M, Reed RB, Shun TY, Wang QJ, Wipf P, Lazo JS.

PLoS One. 2011;6(10):e25134. doi: 10.1371/journal.pone.0025134. Epub 2011 Oct 5.

2.

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

Sharlow ER, Giridhar KV, LaValle CR, Chen J, Leimgruber S, Barrett R, Bravo-Altamirano K, Wipf P, Lazo JS, Wang QJ.

J Biol Chem. 2008 Nov 28;283(48):33516-26. doi: 10.1074/jbc.M805358200. Epub 2008 Sep 30.

3.

A targeted library screen reveals a new inhibitor scaffold for protein kinase D.

Tandon M, Wang L, Xu Q, Xie X, Wipf P, Wang QJ.

PLoS One. 2012;7(9):e44653. doi: 10.1371/journal.pone.0044653. Epub 2012 Sep 18.

4.

Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB.

J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16.

5.

The design, annotation, and application of a kinase-targeted library.

Xi H, Lunney EA.

Methods Mol Biol. 2011;685:279-91. doi: 10.1007/978-1-60761-931-4_14.

PMID:
20981529
6.

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D.

J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p.

PMID:
19572644
7.

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR.

J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4.

PMID:
26538432
8.

Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916.

Rybin VO, Guo J, Steinberg SF.

J Biol Chem. 2009 Jan 23;284(4):2332-43. doi: 10.1074/jbc.M806381200. Epub 2008 Nov 24.

9.

A historical overview of protein kinases and their targeted small molecule inhibitors.

Roskoski R Jr.

Pharmacol Res. 2015 Oct;100:1-23. doi: 10.1016/j.phrs.2015.07.010. Epub 2015 Jul 21. Review.

PMID:
26207888
10.

Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors.

Fang Z, Simard JR, Plenker D, Nguyen HD, Phan T, Wolle P, Baumeister S, Rauh D.

ACS Chem Biol. 2015 Jan 16;10(1):279-88. doi: 10.1021/cb500355c. Epub 2014 Jul 3.

PMID:
24959717
11.

Developments in selective small molecule ATP-targeting the serine/threonine kinase Akt/PKB.

Wang P, Zhang L, Hao Q, Zhao G.

Mini Rev Med Chem. 2011 Nov;11(13):1093-107. Review.

PMID:
22353219
12.

Identification of novel inhibitors of tropomyosin-related kinase A through the structure-based virtual screening with homology-modeled protein structure.

Park H, Chi O, Kim J, Hong S.

J Chem Inf Model. 2011 Nov 28;51(11):2986-93. doi: 10.1021/ci200378s. Epub 2011 Nov 2.

PMID:
22017333
13.

Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.

Chen J, Deng F, Li J, Wang QJ.

Biochem J. 2008 Apr 15;411(2):333-42.

PMID:
18076381
14.

Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1.

Yun T, Qin T, Liu Y, Lai L.

ChemMedChem. 2016 Apr 5;11(7):713-7. doi: 10.1002/cmdc.201600051. Epub 2016 Mar 8.

PMID:
27061239
15.

New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells.

Tandon M, Johnson J, Li Z, Xu S, Wipf P, Wang QJ.

PLoS One. 2013 Sep 23;8(9):e75601. doi: 10.1371/journal.pone.0075601. eCollection 2013.

16.

Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase.

van Linden OP, Farenc C, Zoutman WH, Hameetman L, Wijtmans M, Leurs R, Tensen CP, Siegal G, de Esch IJ.

Eur J Med Chem. 2012 Jan;47(1):493-500. doi: 10.1016/j.ejmech.2011.11.020. Epub 2011 Nov 18.

PMID:
22137457
17.
18.

A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities.

Chen J, Giridhar KV, Zhang L, Xu S, Wang QJ.

Carcinogenesis. 2011 Aug;32(8):1198-206. doi: 10.1093/carcin/bgr113. Epub 2011 Jun 10.

19.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Comess KM, Sun C, Abad-Zapatero C, Goedken ER, Gum RJ, Borhani DW, Argiriadi M, Groebe DR, Jia Y, Clampit JE, Haasch DL, Smith HT, Wang S, Song D, Coen ML, Cloutier TE, Tang H, Cheng X, Quinn C, Liu B, Xin Z, Liu G, Fry EH, Stoll V, Ng TI, Banach D, Marcotte D, Burns DJ, Calderwood DJ, Hajduk PJ.

ACS Chem Biol. 2011 Mar 18;6(3):234-44. doi: 10.1021/cb1002619. Epub 2011 Jan 20.

PMID:
21090814
20.

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S.

Mol Cancer Ther. 2010 May;9(5):1136-46. doi: 10.1158/1535-7163.MCT-09-1145. Epub 2010 May 4. Erratum in: Mol Cancer Ther. 2010 Jul;9(7):2153. Bagherazadeh, Azadeh [corrected to Bagherzadeh, Azadeh].

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