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Items: 1 to 20 of 140

1.

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.

Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, Hayden MR.

Diabetes. 2011 Dec;60(12):3186-96. doi: 10.2337/db11-0081. Epub 2011 Oct 12.

2.

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice.

Kruit JK, Kremer PH, Dai L, Tang R, Ruddle P, de Haan W, Brunham LR, Verchere CB, Hayden MR.

Diabetologia. 2010 Jun;53(6):1110-9. doi: 10.1007/s00125-010-1691-2. Epub 2010 Mar 13.

PMID:
20229095
3.

Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.

Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR.

Diabetes. 2012 Mar;61(3):659-64. doi: 10.2337/db11-1341. Epub 2012 Feb 7.

4.

miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.

Wijesekara N, Zhang LH, Kang MH, Abraham T, Bhattacharjee A, Warnock GL, Verchere CB, Hayden MR.

Diabetes. 2012 Mar;61(3):653-8. doi: 10.2337/db11-0944. Epub 2012 Feb 7.

5.

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.

Wijesekara N, Kaur A, Westwell-Roper C, Nackiewicz D, Soukhatcheva G, Hayden MR, Verchere CB.

Diabetologia. 2016 Jun;59(6):1242-6. doi: 10.1007/s00125-016-3907-6. Epub 2016 Mar 12.

PMID:
26970755
6.

Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145.

Kang MH, Zhang LH, Wijesekara N, de Haan W, Butland S, Bhattacharjee A, Hayden MR.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2724-32. doi: 10.1161/ATVBAHA.113.302004. Epub 2013 Oct 17.

PMID:
24135019
7.

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR.

Nat Med. 2007 Mar;13(3):340-7. Epub 2007 Feb 18.

PMID:
17322896
8.

Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction.

Vergeer M, Brunham LR, Koetsveld J, Kruit JK, Verchere CB, Kastelein JJ, Hayden MR, Stroes ES.

Diabetes Care. 2010 Apr;33(4):869-74. doi: 10.2337/dc09-1562. Epub 2010 Jan 12.

9.

Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.

Pigeau GM, Kolic J, Ball BJ, Hoppa MB, Wang YW, Rückle T, Woo M, Manning Fox JE, MacDonald PE.

Diabetes. 2009 Sep;58(9):2084-92. doi: 10.2337/db08-1371. Epub 2009 Jun 23.

10.

Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice.

Liu T, Li H, Gounko NV, Zhou Z, Xu A, Hong W, Han W.

Am J Physiol Endocrinol Metab. 2014 Oct 1;307(7):E611-8. doi: 10.1152/ajpendo.00208.2014. Epub 2014 Aug 19.

11.

Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.

Collins SC, Hoppa MB, Walker JN, Amisten S, Abdulkader F, Bengtsson M, Fearnside J, Ramracheya R, Toye AA, Zhang Q, Clark A, Gauguier D, Rorsman P.

Diabetes. 2010 May;59(5):1192-201. doi: 10.2337/db09-0791. Epub 2010 Feb 11.

12.

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.

Sturek JM, Castle JD, Trace AP, Page LC, Castle AM, Evans-Molina C, Parks JS, Mirmira RG, Hedrick CC.

J Clin Invest. 2010 Jul;120(7):2575-89. doi: 10.1172/JCI41280. Epub 2010 Jun 7.

13.

Cholesterol in islet dysfunction and type 2 diabetes.

Brunham LR, Kruit JK, Verchere CB, Hayden MR.

J Clin Invest. 2008 Feb;118(2):403-8. doi: 10.1172/JCI33296. Review.

14.

Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adults.

Rickels MR, Goeser ES, Fuller C, Lord C, Bowler AM, Doliba NM, Hegele RA, Cuchel M.

Diabetes. 2015 Jan;64(1):193-9. doi: 10.2337/db14-0436. Epub 2014 Aug 14.

15.

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.

16.

Hepatic ABCA1 expression improves β-cell function and glucose tolerance.

de Haan W, Karasinska JM, Ruddle P, Hayden MR.

Diabetes. 2014 Dec;63(12):4076-82. doi: 10.2337/db14-0548. Epub 2014 Jul 15.

17.

Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P.

J Physiol. 2004 May 1;556(Pt 3):711-26. Epub 2004 Feb 13.

18.

Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells.

Zhu D, Koo E, Kwan E, Kang Y, Park S, Xie H, Sugita S, Gaisano HY.

Diabetologia. 2013 Feb;56(2):359-69. doi: 10.1007/s00125-012-2757-0. Epub 2012 Nov 7.

PMID:
23132338
19.
20.

Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol.

Nagaraj V, Kazim AS, Helgeson J, Lewold C, Barik S, Buda P, Reinbothe TM, Wennmalm S, Zhang E, Renström E.

Mol Endocrinol. 2016 Oct;30(10):1059-1069. Epub 2016 Aug 17.

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