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Items: 1 to 20 of 102

1.

βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis.

Ma B, Sen T, Asnaghi L, Valapala M, Yang F, Hose S, McLeod DS, Lu Y, Eberhart C, Zigler JS Jr, Sinha D.

Cell Death Dis. 2011 Oct 13;2:e217. doi: 10.1038/cddis.2011.100.

2.

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.

Valapala M, Edwards M, Hose S, Hu J, Wawrousek E, Lutty GA, Zigler JS Jr, Qian J, Sinha D.

Sci Rep. 2015 Mar 4;5:8755. doi: 10.1038/srep08755.

3.

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.

Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Cano M, Hackett S, Xu G, Lutty GA, Dong L, Sergeev Y, Handa JT, Campochiaro P, Wawrousek E, Zigler JS Jr, Sinha D.

Autophagy. 2014 Mar;10(3):480-96. doi: 10.4161/auto.27292. Epub 2014 Jan 23.

4.

βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina.

Sinha D, Valapala M, Bhutto I, Patek B, Zhang C, Hose S, Yang F, Cano M, Stark WJ, Lutty GA, Zigler JS, Wawrousek EF.

Transgenic Res. 2012 Oct;21(5):1033-42. doi: 10.1007/s11248-012-9608-0. Epub 2012 Mar 17.

5.

Protein kinase D is a positive regulator of Bit1 apoptotic function.

Biliran H, Jan Y, Chen R, Pasquale EB, Ruoslahti E.

J Biol Chem. 2008 Oct 17;283(42):28029-37. doi: 10.1074/jbc.M803139200. Epub 2008 Aug 14. Erratum in: J Biol Chem. 2011 Mar 4;286(9):7714.

6.

Expression of βA3/A1-crystallin in the developing and adult rat eye.

Parthasarathy G, Ma B, Zhang C, Gongora C, Samuel Zigler J Jr, Duncan MK, Sinha D.

J Mol Histol. 2011 Feb;42(1):59-69. doi: 10.1007/s10735-010-9307-1. Epub 2011 Jan 4.

7.

Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria.

Zhu Z, Li R, Stricker R, Reiser G.

Brain Res. 2015 Sep 16;1620:17-28. doi: 10.1016/j.brainres.2015.05.011. Epub 2015 May 18.

PMID:
25998538
8.

βA3/A1-crystallin: more than a lens protein.

Zigler JS Jr, Sinha D.

Prog Retin Eye Res. 2015 Jan;44:62-85. doi: 10.1016/j.preteyeres.2014.11.002. Epub 2014 Nov 13. Review.

9.

βA3/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye.

Zigler JS Jr, Valapala M, Shang P, Hose S, Goldberg MF, Sinha D.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):287-98. doi: 10.1016/j.bbagen.2015.05.017. Epub 2015 May 31. Review.

10.

Modulation of V-ATPase by βA3/A1-Crystallin in Retinal Pigment Epithelial Cells.

Valapala M, Sergeev Y, Wawrousek E, Hose S, Zigler JS Jr, Sinha D.

Adv Exp Med Biol. 2016;854:779-84. doi: 10.1007/978-3-319-17121-0_104.

PMID:
26427489
11.

Human βA3/A1-crystallin splicing mutation causes cataracts by activating the unfolded protein response and inducing apoptosis in differentiating lens fiber cells.

Ma Z, Yao W, Chan CC, Kannabiran C, Wawrousek E, Hejtmancik JF.

Biochim Biophys Acta. 2016 Jun;1862(6):1214-27. doi: 10.1016/j.bbadis.2016.02.003. Epub 2016 Feb 4.

12.

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.

Zigler JS Jr, Zhang C, Grebe R, Sehrawat G, Hackler L Jr, Adhya S, Hose S, McLeod DS, Bhutto I, Barbour W, Parthasarathy G, Zack DJ, Sergeev Y, Lutty GA, Handa JT, Sinha D.

J Cell Sci. 2011 Feb 15;124(Pt 4):523-31. doi: 10.1242/jcs.078790. Epub 2011 Jan 25.

13.

Anoikis effector Bit1 negatively regulates Erk activity.

Kairouz-Wahbe R, Biliran H, Luo X, Khor I, Wankell M, Besch-Williford C, Pascual J, Oshima R, Ruoslahti E.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1528-32. doi: 10.1073/pnas.0711357105. Epub 2008 Jan 24.

14.

CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation.

Hegde S, Kesterson RA, Srivastava OP.

PLoS One. 2016 Feb 10;11(2):e0149027. doi: 10.1371/journal.pone.0149027. eCollection 2016.

15.

Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels.

Alfano D, Iaccarino I, Stoppelli MP.

J Biol Chem. 2006 Jun 30;281(26):17758-67. Epub 2006 Apr 21.

16.

Estrogen decreases anoikis of ovarian cancer cell line Caov-3 through reducing release of Bit1.

Zheng J, Zhou J, Xie X, Xie B, Lin J, Xu Z, Zhang W.

DNA Cell Biol. 2014 Dec;33(12):847-53. doi: 10.1089/dna.2014.2453.

PMID:
25211327
17.

Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway.

Subramaniam S, Shahani N, Strelau J, Laliberté C, Brandt R, Kaplan D, Unsicker K.

J Neurosci. 2005 Mar 16;25(11):2838-52.

18.

Cell-cell contacts prevent anoikis in primary human colonic epithelial cells.

Hofmann C, Obermeier F, Artinger M, Hausmann M, Falk W, Schoelmerich J, Rogler G, Grossmann J.

Gastroenterology. 2007 Feb;132(2):587-600. Epub 2006 Nov 16.

PMID:
17258732
19.

betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development.

Sinha D, Klise A, Sergeev Y, Hose S, Bhutto IA, Hackler L Jr, Malpic-Llanos T, Samtani S, Grebe R, Goldberg MF, Hejtmancik JF, Nath A, Zack DJ, Fariss RN, McLeod DS, Sundin O, Broman KW, Lutty GA, Zigler JS Jr.

Mol Cell Neurosci. 2008 Jan;37(1):85-95. Epub 2007 Aug 31.

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