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Targeting of a chlamydial protease impedes intracellular bacterial growth.

Christian JG, Heymann J, Paschen SA, Vier J, Schauenburg L, Rupp J, Meyer TF, Häcker G, Heuer D.

PLoS Pathog. 2011 Sep;7(9):e1002283. doi: 10.1371/journal.ppat.1002283. Epub 2011 Sep 29.


Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction.

Heuer D, Rejman Lipinski A, Machuy N, Karlas A, Wehrens A, Siedler F, Brinkmann V, Meyer TF.

Nature. 2009 Feb 5;457(7230):731-5. doi: 10.1038/nature07578. Epub 2008 Dec 7.


Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF.

Dille S, Herbst K, Volceanov L, Nölke T, Kretz O, Häcker G.

PLoS One. 2014 Jul 28;9(7):e103220. doi: 10.1371/journal.pone.0103220. eCollection 2014.


Cleavage of the NF-κB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae.

Christian J, Vier J, Paschen SA, Häcker G.

J Biol Chem. 2010 Dec 31;285(53):41320-7. doi: 10.1074/jbc.M110.152280. Epub 2010 Nov 1.


Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation.

Rejman Lipinski A, Heymann J, Meissner C, Karlas A, Brinkmann V, Meyer TF, Heuer D.

PLoS Pathog. 2009 Oct;5(10):e1000615. doi: 10.1371/journal.ppat.1000615. Epub 2009 Oct 9.


Rab GTPases are recruited to chlamydial inclusions in both a species-dependent and species-independent manner.

Rzomp KA, Scholtes LD, Briggs BJ, Whittaker GR, Scidmore MA.

Infect Immun. 2003 Oct;71(10):5855-70.


Chlamydia trachomatis infection prevents front-rear polarity of migrating HeLa cells.

Heymann J, Rejman Lipinski A, Bauer B, Meyer TF, Heuer D.

Cell Microbiol. 2013 Jul;15(7):1059-69. doi: 10.1111/cmi.12114. Epub 2013 Feb 21.


Characterization of a secreted Chlamydia protease.

Shaw AC, Vandahl BB, Larsen MR, Roepstorff P, Gevaert K, Vandekerckhove J, Christiansen G, Birkelund S.

Cell Microbiol. 2002 Jul;4(7):411-24.


CPAF: a Chlamydial protease in search of an authentic substrate.

Chen AL, Johnson KA, Lee JK, Sütterlin C, Tan M.

PLoS Pathog. 2012;8(8):e1002842. doi: 10.1371/journal.ppat.1002842. Epub 2012 Aug 2.


In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport.

Dille S, Kleinschnitz EM, Kontchou CW, Nölke T, Häcker G.

Infect Immun. 2015 Aug;83(8):3268-80. doi: 10.1128/IAI.00322-15. Epub 2015 Jun 8.


The host adherens junction molecule nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells.

Sun J, Schoborg RV.

Microbes Infect. 2009 Jan;11(1):12-9. doi: 10.1016/j.micinf.2008.10.001. Epub 2008 Oct 18.


Chlamydia trachomatis outer membrane complex protein B (OmcB) is processed by the protease CPAF.

Hou S, Lei L, Yang Z, Qi M, Liu Q, Zhong G.

J Bacteriol. 2013 Mar;195(5):951-7. doi: 10.1128/JB.02087-12. Epub 2012 Dec 7.


Chlamydia trachomatis remodels stable microtubules to coordinate Golgi stack recruitment to the chlamydial inclusion surface.

Al-Zeer MA, Al-Younes HM, Kerr M, Abu-Lubad M, Gonzalez E, Brinkmann V, Meyer TF.

Mol Microbiol. 2014 Dec;94(6):1285-97. doi: 10.1111/mmi.12829. Epub 2014 Nov 3.


The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence.

Jorgensen I, Bednar MM, Amin V, Davis BK, Ting JP, McCafferty DG, Valdivia RH.

Cell Host Microbe. 2011 Jul 21;10(1):21-32. doi: 10.1016/j.chom.2011.06.008.


Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor.

Bednar MM, Jorgensen I, Valdivia RH, McCafferty DG.

Biochemistry. 2011 Sep 6;50(35):7441-3. doi: 10.1021/bi201098r. Epub 2011 Aug 15.


Persistent Chlamydia trachomatis infection of HeLa cells mediates apoptosis resistance through a Chlamydia protease-like activity factor-independent mechanism and induces high mobility group box 1 release.

Rödel J, Grosse C, Yu H, Wolf K, Otto GP, Liebler-Tenorio E, Forsbach-Birk V, Straube E.

Infect Immun. 2012 Jan;80(1):195-205. doi: 10.1128/IAI.05619-11. Epub 2011 Oct 24.


Chlamydia-secreted protease CPAF degrades host antimicrobial peptides.

Tang L, Chen J, Zhou Z, Yu P, Yang Z, Zhong G.

Microbes Infect. 2015 Jun;17(6):402-8. doi: 10.1016/j.micinf.2015.02.005. Epub 2015 Mar 6.


Chlamydia pneumoniae inclusion membrane protein Cpn0585 interacts with multiple Rab GTPases.

Cortes C, Rzomp KA, Tvinnereim A, Scidmore MA, Wizel B.

Infect Immun. 2007 Dec;75(12):5586-96. Epub 2007 Oct 1.


Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection.

Yang Z, Tang L, Sun X, Chai J, Zhong G.

Infect Immun. 2015 Jun;83(6):2234-41. doi: 10.1128/IAI.00275-15. Epub 2015 Mar 16.

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