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Significant mobilization of both conventional and regulatory T cells with AMD3100.

Kean LS, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, Bonifacino AC, Metzger ME, Promislow DE, Mattapallil JJ, Donahue RE.

Blood. 2011 Dec 15;118(25):6580-90. doi: 10.1182/blood-2011-06-359331. Epub 2011 Oct 11.


Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10.

MacDonald KP, Le Texier L, Zhang P, Morris H, Kuns RD, Lineburg KE, Leveque L, Don AL, Markey KA, Vuckovic S, Bagger FO, Boyle GM, Blazar BR, Hill GR.

J Immunol. 2014 Apr 1;192(7):3180-9. doi: 10.4049/jimmunol.1302315. Epub 2014 Feb 28.


AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.

Larochelle A, Krouse A, Metzger M, Orlic D, Donahue RE, Fricker S, Bridger G, Dunbar CE, Hematti P.

Blood. 2006 May 1;107(9):3772-8. Epub 2006 Jan 26.


Higher frequency of regulatory T cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow grafts compared with G-CSF-primed peripheral blood grafts.

Zhao XY, Wang YT, Mo XD, Zhao XS, Wang YZ, Chang YJ, Huang XJ.

J Transl Med. 2015 May 7;13:145. doi: 10.1186/s12967-015-0507-z.


Functional regulatory T cells are collected in stem cell autografts by mobilization with high-dose cyclophosphamide and granulocyte colony-stimulating factor.

Condomines M, Quittet P, Lu ZY, Nadal L, Latry P, Lopez E, Baudard M, Requirand G, Duperray C, Schved JF, Rossi JF, Tarte K, Klein B.

J Immunol. 2006 Jun 1;176(11):6631-9. Erratum in: J Immunol. 2006 Oct 15;177(8):5748.


Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application.

Ukena SN, Velaga S, Goudeva L, Ivanyi P, Olek S, Falk CS, Ganser A, Franzke A.

PLoS One. 2012;7(12):e51644. doi: 10.1371/journal.pone.0051644. Epub 2012 Dec 12.


G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo.

Toh HC, Sun L, Soe Y, Wu Y, Phoon YP, Chia WK, Wu J, Wong KY, Tan P.

Clin Immunol. 2009 Jul;132(1):83-92. doi: 10.1016/j.clim.2009.03.509. Epub 2009 Apr 2.


Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist.

Liles WC, Rodger E, Broxmeyer HE, Dehner C, Badel K, Calandra G, Christensen J, Wood B, Price TH, Dale DC.

Transfusion. 2005 Mar;45(3):295-300.


Differences in the phenotype, cytokine gene expression profiles, and in vivo alloreactivity of T cells mobilized with plerixafor compared with G-CSF.

Lundqvist A, Smith AL, Takahashi Y, Wong S, Bahceci E, Cook L, Ramos C, Tawab A, McCoy JP Jr, Read EJ, Khuu HM, Bolan CD, Joo J, Geller N, Leitman SF, Calandra G, Dunbar C, Kurlander R, Childs RW.

J Immunol. 2013 Dec 15;191(12):6241-9. doi: 10.4049/jimmunol.1301148. Epub 2013 Nov 15.


Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.

Sobel ES, Brusko TM, Butfiloski EJ, Hou W, Li S, Cuda CM, Abid AN, Reeves WH, Morel L.

Arthritis Res Ther. 2011 Jun 27;13(3):R106. doi: 10.1186/ar3387.


Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures.

Donahue RE, Jin P, Bonifacino AC, Metzger ME, Ren J, Wang E, Stroncek DF.

Blood. 2009 Sep 17;114(12):2530-41. doi: 10.1182/blood-2009-04-214403. Epub 2009 Jul 14.


Impact of donor hematopoietic cells mobilized with G-CSF and plerixafor on murine acute graft-versus-host-disease.

Arbez J, Saas P, Lamarthée B, Malard F, Couturier M, Mohty M, Gaugler B.

Cytotherapy. 2015 Jul;17(7):948-55. doi: 10.1016/j.jcyt.2015.02.009. Epub 2015 Mar 23.


Role of CD4+CD25+highFoxp3+CD62L+ regulatory T cells and invariant NKT cells in human allogeneic hematopoietic stem cell transplantation.

Vela-Ojeda J, Montiel-Cervantes L, Granados-Lara P, Reyes-Maldonado E, García-Latorre E, Garcia-Chavez J, Majluf-Cruz A, Mayani H, Borbolla-Escoboza JR, Esparza MG.

Stem Cells Dev. 2010 Mar;19(3):333-40. doi: 10.1089/scd.2009.0216.


In and out of the niche: perspectives in mobilization of hematopoietic stem cells.

Mohty M, Ho AD.

Exp Hematol. 2011 Jul;39(7):723-9. doi: 10.1016/j.exphem.2011.05.004. Epub 2011 May 13. Review.


OMIP-015: human regulatory and activated T-cells without intracellular staining.

Mahnke YD, Beddall MH, Roederer M.

Cytometry A. 2013 Feb;83(2):179-81. doi: 10.1002/cyto.a.22230. Epub 2012 Nov 16. No abstract available.


The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone.

Flomenberg N, Devine SM, Dipersio JF, Liesveld JL, McCarty JM, Rowley SD, Vesole DH, Badel K, Calandra G.

Blood. 2005 Sep 1;106(5):1867-74. Epub 2005 May 12.

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