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Items: 1 to 20 of 93

1.

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.

Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M.

Nature. 2011 Oct 9;479(7371):122-6. doi: 10.1038/nature10507.

2.

PHD2 regulates arteriogenic macrophages through TIE2 signalling.

Hamm A, Veschini L, Takeda Y, Costa S, Delamarre E, Squadrito ML, Henze AT, Wenes M, Serneels J, Pucci F, Roncal C, Anisimov A, Alitalo K, De Palma M, Mazzone M.

EMBO Mol Med. 2013 Jun;5(6):843-57. doi: 10.1002/emmm.201302695.

3.

P2Y2 nucleotide receptor mediates arteriogenesis in a murine model of hind limb ischemia.

McEnaney RM, Shukla A, Madigan MC, Sachdev U, Tzeng E.

J Vasc Surg. 2016 Jan;63(1):216-25. doi: 10.1016/j.jvs.2014.06.112.

4.

Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.

Kunze R, Zhou W, Veltkamp R, Wielockx B, Breier G, Marti HH.

Stroke. 2012 Oct;43(10):2748-56.

5.

Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.

Schultz K, Murthy V, Tatro JB, Beasley D.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L921-7. doi: 10.1152/ajplung.90393.2008.

6.

Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance.

Matsuura H, Ichiki T, Inoue E, Nomura M, Miyazaki R, Hashimoto T, Ikeda J, Takayanagi R, Fong GH, Sunagawa K.

Circulation. 2013 May 28;127(21):2078-87. doi: 10.1161/CIRCULATIONAHA.113.001742.

7.

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.

Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P.

Cell. 2009 Mar 6;136(5):839-51. doi: 10.1016/j.cell.2009.01.020.

8.

The temporal and spatial distribution of macrophage subpopulations during arteriogenesis.

Troidl C, Jung G, Troidl K, Hoffmann J, Mollmann H, Nef H, Schaper W, Hamm CW, Schmitz-Rixen T.

Curr Vasc Pharmacol. 2013 Jan;11(1):5-12.

PMID:
23391417
9.

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C.

J Clin Invest. 2015 Jul 1;125(7):2759-71. doi: 10.1172/JCI80369.

10.

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M.

J Immunol. 2012 Aug 15;189(4):1955-65. doi: 10.4049/jimmunol.1103471.

11.

Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice.

Schirmer SH, Fledderus JO, Bot PT, Moerland PD, Hoefer IE, Baan J Jr, Henriques JP, van der Schaaf RJ, Vis MM, Horrevoets AJ, Piek JJ, van Royen N.

Circ Res. 2008 May 23;102(10):1286-94. doi: 10.1161/CIRCRESAHA.108.171827.

12.

Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer.

Su Y, Loos M, Giese N, Metzen E, Büchler MW, Friess H, Kornberg A, Büchler P.

Cancer. 2012 Feb 15;118(4):960-72. doi: 10.1002/cncr.26344.

13.
14.

Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.

Kalucka J, Ettinger A, Franke K, Mamlouk S, Singh RP, Farhat K, Muschter A, Olbrich S, Breier G, Katschinski DM, Huttner W, Weidemann A, Wielockx B.

Mol Cell Biol. 2013 Sep;33(17):3426-38. doi: 10.1128/MCB.00609-13.

15.

Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.

Takeda K, Duan LJ, Takeda H, Fong GH.

Am J Pathol. 2014 Mar;184(3):686-96. doi: 10.1016/j.ajpath.2013.11.032.

16.

Prolyl hydroxylase domain protein 2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium.

Wang WE, Yang D, Li L, Wang W, Peng Y, Chen C, Chen P, Xia X, Wang H, Jiang J, Liao Q, Li Y, Xie G, Huang H, Guo Y, Ye L, Duan DD, Chen X, Houser SR, Zeng C.

Circ Res. 2013 Jul 19;113(3):288-300. doi: 10.1161/CIRCRESAHA.113.300929.

17.

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Kuchnio A, Moens S, Bruning U, Kuchnio K, Cruys B, Thienpont B, Broux M, Ungureanu AA, Leite de Oliveira R, Bruyère F, Cuervo H, Manderveld A, Carton A, Hernandez-Fernaud JR, Zanivan S, Bartic C, Foidart JM, Noel A, Vinckier S, Lambrechts D, Dewerchin M, Mazzone M, Carmeliet P.

Cell Rep. 2015 Aug 11;12(6):992-1005. doi: 10.1016/j.celrep.2015.07.010.

18.

HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia.

HoWangYin KY, Loinard C, Bakker W, Guérin CL, Vilar J, d'Audigier C, Mauge L, Bruneval P, Emmerich J, Lévy BI, Pouysségur J, Smadja DM, Silvestre JS.

Stem Cells. 2014 Jan;32(1):231-43. doi: 10.1002/stem.1540. Erratum in: Stem Cells. 2014 Apr;32(4):1055-7. D'Audigier, Clément [corrected to d'Audigier, Clément].

19.

Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.

Heindryckx F, Kuchnio A, Casteleyn C, Coulon S, Olievier K, Colle I, Geerts A, Libbrecht L, Carmeliet P, Van Vlierberghe H.

J Hepatol. 2012 Jul;57(1):61-8. doi: 10.1016/j.jhep.2012.02.021.

PMID:
22420978
20.

Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.

Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV.

J Biol Chem. 2015 Mar 13;290(11):7195-207. doi: 10.1074/jbc.M114.611483.

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