Similar articles for PMID: 21982494

Year	Number of Results
1995	2
1999	1
2000	1
2001	3
2002	3
2003	3
2004	2
2005	7
2006	8
2007	8
2008	12
2009	9
2010	6
2011	8
2012	6
2013	5
2014	6
2015	1
2016	2
2017	1
2019	1
2024	0

1

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

Hu Y, Xing L, Thomason JR, Xiang J, Ipek M, Guler S, Li H, Sabatini J, Chockalingam P, Reifenberg E, Sheldon R, Morris EA, Georgiadis KE, Tam S. Hu Y, et al. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6800-3. doi: 10.1016/j.bmcl.2011.09.036. Epub 2011 Sep 18. Bioorg Med Chem Lett. 2011. PMID: 21982494

2

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

Xiang JS, Hu Y, Rush TS, Thomason JR, Ipek M, Sum PE, Abrous L, Sabatini JJ, Georgiadis K, Reifenberg E, Majumdar M, Morris EA, Tam S. Xiang JS, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. doi: 10.1016/j.bmcl.2005.10.001. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275085

3

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.

Hopper DW, Vera MD, How D, Sabatini J, Xiang JS, Ipek M, Thomason J, Hu Y, Feyfant E, Wang Q, Georgiadis KE, Reifenberg E, Sheldon RT, Keohan CC, Majumdar MK, Morris EA, Skotnicki J, Sum PE. Hopper DW, et al. Bioorg Med Chem Lett. 2009 May 1;19(9):2487-91. doi: 10.1016/j.bmcl.2009.03.056. Epub 2009 Mar 18. Bioorg Med Chem Lett. 2009. PMID: 19329309

4

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

Nuti E, Santamaria S, Casalini F, Yamamoto K, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Marini AM, Salerno S, Taliani S, Da Settimo F, Nagase H, Rossello A. Nuti E, et al. Eur J Med Chem. 2013 Apr;62:379-94. doi: 10.1016/j.ejmech.2012.12.058. Epub 2013 Jan 11. Eur J Med Chem. 2013. PMID: 23376997

5

Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.

Durham TB, Klimkowski VJ, Rito CJ, Marimuthu J, Toth JL, Liu C, Durbin JD, Stout SL, Adams L, Swearingen C, Lin C, Chambers MG, Thirunavukkarasu K, Wiley MR. Durham TB, et al. J Med Chem. 2014 Dec 26;57(24):10476-85. doi: 10.1021/jm501522n. Epub 2014 Dec 5. J Med Chem. 2014. PMID: 25415648

6

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors.

Peng L, Duan L, Liu X, Shen M, Li Y, Yan J, Li H, Ding K. Peng L, et al. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4457-61. doi: 10.1016/j.bmcl.2011.06.009. Epub 2011 Jun 16. Bioorg Med Chem Lett. 2011. PMID: 21733683

7

In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage.

Steinmeyer J, Kordelle J, Stürz H. Steinmeyer J, et al. J Orthop Res. 2010 Jun;28(6):828-33. doi: 10.1002/jor.21026. J Orthop Res. 2010. PMID: 20069635 Free article.

8

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.

De Savi C, Pape A, Cumming JG, Ting A, Smith PD, Burrows JN, Mills M, Davies C, Lamont S, Milne D, Cook C, Moore P, Sawyer Y, Gerhardt S. De Savi C, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1376-81. doi: 10.1016/j.bmcl.2011.01.036. Epub 2011 Jan 18. Bioorg Med Chem Lett. 2011. PMID: 21300546

9

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.

De Savi C, Pape A, Sawyer Y, Milne D, Davies C, Cumming JG, Ting A, Lamont S, Smith PD, Tart J, Page K, Moore P. De Savi C, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. doi: 10.1016/j.bmcl.2011.04.028. Epub 2011 Apr 13. Bioorg Med Chem Lett. 2011. PMID: 21536437

10

Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors.

Shiozaki M, Imai H, Maeda K, Miura T, Yasue K, Suma A, Yokota M, Ogoshi Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, Inaba T. Shiozaki M, et al. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6213-7. doi: 10.1016/j.bmcl.2009.08.093. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19767207

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