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Items: 1 to 20 of 125

1.

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT.

Mol Cell. 2011 Oct 7;44(1):134-46. doi: 10.1016/j.molcel.2011.06.038.

2.

K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.

Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J, Diaz-Meco MT.

Mol Cell. 2013 Aug 8;51(3):283-96. doi: 10.1016/j.molcel.2013.06.020. Epub 2013 Aug 1.

3.

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Oshiro N, Rapley J, Avruch J.

J Biol Chem. 2014 Jan 31;289(5):2658-74. doi: 10.1074/jbc.M113.528505. Epub 2013 Dec 11.

4.

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.

Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT.

Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13.

5.

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.

6.

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM.

Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032.

7.

Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.

Kwak SS, Kang KH, Kim S, Lee S, Lee JH, Kim JW, Byun B, Meadows GG, Joe CO.

Cell Signal. 2016 Feb;28(2):32-41. doi: 10.1016/j.cellsig.2015.11.008. Epub 2015 Nov 12.

PMID:
26582740
8.

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Ögmundsdóttir MH, Heublein S, Kazi S, Reynolds B, Visvalingam SM, Shaw MK, Goberdhan DC.

PLoS One. 2012;7(5):e36616. doi: 10.1371/journal.pone.0036616. Epub 2012 May 4.

9.

Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1.

Huang S, Yang ZJ, Yu C, Sinicrope FA.

J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23.

10.

Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.

Wu D, Chapman JR, Wang L, Harris TE, Shabanowitz J, Hunt DF, Fu Z.

J Biol Chem. 2012 Apr 6;287(15):12510-9. doi: 10.1074/jbc.M111.302117. Epub 2012 Feb 22.

11.

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.

12.

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Katsuragi Y, Ichimura Y, Komatsu M.

FEBS J. 2015 Dec;282(24):4672-8. doi: 10.1111/febs.13540. Epub 2015 Oct 16. Review.

13.

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.

Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.

14.

Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Review.

15.

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.

16.

SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.

Kim YM, Stone M, Hwang TH, Kim YG, Dunlevy JR, Griffin TJ, Kim DH.

Mol Cell. 2012 Jun 29;46(6):833-46. doi: 10.1016/j.molcel.2012.04.007. Epub 2012 May 9.

17.

Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway.

Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O.

Int J Oncol. 2013 Aug;43(2):447-56. doi: 10.3892/ijo.2013.1984. Epub 2013 Jun 12.

PMID:
23759924
18.

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.

Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ, Henske EP.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12455-60. doi: 10.1073/pnas.1104361108. Epub 2011 Jul 11.

19.

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM.

Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044.

20.

Rags connect mTOR and autophagy.

Narita M, Inoki K.

Small GTPases. 2012 Apr-Jun;3(2):111-4. doi: 10.4161/sgtp.19422.

PMID:
22790199

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